Open Access

Virulence

, volume 10 , issue 1 , pages 976-983

Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis

Cornelia Speth ^{1, 2}

Günter Rambach ^{1, 2}

Cornelia Lass-Flörl ^{1, 2}

P. Lynne HOWELL ^{3, 4}

Donald C. Sheppard ^{5, 6}

Hide authors affiliations Show authors affiliations: 6 affiliations

Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria |

Christian Doppler Laboratory for Invasive Fungal Infections, Innsbruck, Austria |

Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada |

⁴

Department of Biochemistry, University of Toronto, Toronto, Canada |

⁵

Departments of Medicine and of Microbiology and Immunology, McGill University, Montréal, Canada |

⁶

Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada |

Publication type: Journal Article

Publication date: 2019-01-01

Taylor & Francis

Virulence

scimago Q1

wos Q1

SJR: 1.585

CiteScore: 10.5

Impact factor: 5.4

ISSN: 21505594, 21505608

DOI: 10.1080/21505594.2019.1568174

Copy DOI

PubMed ID: 30667338

Microbiology (medical)

Microbiology

Infectious Diseases

Immunology

Parasitology

Abstract

Aspergillus spp and particularly the species Aspergillus fumigatus are the causative agents of invasive aspergillosis, a progressive necrotizing pneumonia that occurs in immunocompromised patients. The limited efficacy of currently available antifungals has led to interest in a better understanding of the molecular mechanisms underlying the pathogenesis of invasive aspergillosis in order to identify new therapeutic targets for this devastating disease. The Aspergillus exopolysaccharide galactosaminogalactan (GAG) plays an important role in the pathogenesis of experimental invasive aspergillosis. The present review article summarizes our current understanding of GAG composition and synthesis and the molecular mechanisms whereby GAG promotes virulence. Promising directions for future research and the prospect of GAG as both a therapy and therapeutic target are reviewed.

Found

1 citation

Vasilchenko Alexey

🤝

PhD in Biological/biomedical sciences

70 publications, 894 citations, 45 reviews

1 citation

Shilova Nadya

74 publications, 897 citations

h-index: 17

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

1 citation

Stepanov Artyom

3 publications, 36 citations

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GOST Copy

Speth C. et al. Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis // Virulence. 2019. Vol. 10. No. 1. pp. 976-983.

GOST all authors (up to 50) Copy

Speth C., Rambach G., Lass-Flörl C., HOWELL P., Sheppard D. C. Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis // Virulence. 2019. Vol. 10. No. 1. pp. 976-983.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1080/21505594.2019.1568174

UR - https://doi.org/10.1080/21505594.2019.1568174

TI - Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis

T2 - Virulence

AU - Speth, Cornelia

AU - Rambach, Günter

AU - Lass-Flörl, Cornelia

AU - HOWELL, P. Lynne

AU - Sheppard, Donald C.

PY - 2019

DA - 2019/01/01

PB - Taylor & Francis

SP - 976-983

IS - 1

VL - 10

PMID - 30667338

SN - 2150-5594

SN - 2150-5608

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Speth,

author = {Cornelia Speth and Günter Rambach and Cornelia Lass-Flörl and P. Lynne HOWELL and Donald C. Sheppard},

title = {Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis},

journal = {Virulence},

year = {2019},

volume = {10},

publisher = {Taylor & Francis},

month = {jan},

url = {https://doi.org/10.1080/21505594.2019.1568174},

number = {1},

pages = {976--983},

doi = {10.1080/21505594.2019.1568174}

}

MLA

Cite this

MLA Copy

Speth, Cornelia, et al. “Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis.” Virulence, vol. 10, no. 1, Jan. 2019, pp. 976-983. https://doi.org/10.1080/21505594.2019.1568174.

Publisher

Taylor & Francis

Journal

Virulence

scimago Q1

wos Q1

SJR

1.585

CiteScore

10.5

Impact factor

5.4

ISSN

21505594 (Print)

21505608 (Electronic)