Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.
Publication type: Journal Article
Publication date: 1993-08-01
scimago Q1
wos Q1
SJR: 5.834
CiteScore: 22.1
Impact factor: 10.6
ISSN: 00221007, 15409538
PubMed ID:
8340762
Immunology
Immunology and Allergy
Abstract
Vitamin A (retinol) is an essential cofactor for growth of B lymphocytes in culture and for activation of T lymphocytes by antigen receptor-mediated signals. 14-hydroxy-4,14-retro-retinol (14-HRR) a metabolite of retinol, has been implicated as the intracellular mediator of this effect. Anhydroretinol (AR) is a retinol derivative with retro structure produced in activated human B lymphocytes and the insect cell lines SF 21 and Schneider S2. AR reversibly inhibits retinol- and 14-HRR-dependent effects and blocks B lymphocyte proliferation as well as activation of resting T lymphocytes. The intracellular signaling pathway blocked by AR in T cell activation is distinct from the calcineurin/interleukin 2 pathway inhibitable by cyclosporine A or FK-506.
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Total citations:
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Citations from 2024:
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GOST
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Buck J. et al. Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology. // Journal of Experimental Medicine. 1993. Vol. 178. No. 2. pp. 675-680.
GOST all authors (up to 50)
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Buck J., Grün F., Derguini F., Chen Y., Kimura S., Noy N., Hammerling U. Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology. // Journal of Experimental Medicine. 1993. Vol. 178. No. 2. pp. 675-680.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1084/jem.178.2.675
UR - https://doi.org/10.1084/jem.178.2.675
TI - Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.
T2 - Journal of Experimental Medicine
AU - Buck, J
AU - Grün, F
AU - Derguini, F
AU - Chen, Y.
AU - Kimura, S.
AU - Noy, N
AU - Hammerling, U.
PY - 1993
DA - 1993/08/01
PB - Rockefeller University Press
SP - 675-680
IS - 2
VL - 178
PMID - 8340762
SN - 0022-1007
SN - 1540-9538
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1993_Buck,
author = {J Buck and F Grün and F Derguini and Y. Chen and S. Kimura and N Noy and U. Hammerling},
title = {Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.},
journal = {Journal of Experimental Medicine},
year = {1993},
volume = {178},
publisher = {Rockefeller University Press},
month = {aug},
url = {https://doi.org/10.1084/jem.178.2.675},
number = {2},
pages = {675--680},
doi = {10.1084/jem.178.2.675}
}
Cite this
MLA
Copy
Buck, J., et al. “Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology..” Journal of Experimental Medicine, vol. 178, no. 2, Aug. 1993, pp. 675-680. https://doi.org/10.1084/jem.178.2.675.