Journal of Experimental Medicine, volume 178, issue 2, pages 675-680

Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.

J Buck ¹

F Grün ¹

F Derguini ¹

Y. Chen ¹

S. Kimura ¹

N Noy ¹

U. Hammerling ¹

Show full list: 7 authors

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York 10021. |

Publication type: Journal Article

Publication date: 1993-08-01

Rockefeller University Press

Journal: Journal of Experimental Medicine

scimago Q1

wos Q1

SJR: 6.838

CiteScore: 26.6

Impact factor: 12.6

ISSN: 00221007, 15409538

DOI: 10.1084/jem.178.2.675

Copy DOI

PubMed ID: 8340762

Immunology

Immunology and Allergy

Abstract

Vitamin A (retinol) is an essential cofactor for growth of B lymphocytes in culture and for activation of T lymphocytes by antigen receptor-mediated signals. 14-hydroxy-4,14-retro-retinol (14-HRR) a metabolite of retinol, has been implicated as the intracellular mediator of this effect. Anhydroretinol (AR) is a retinol derivative with retro structure produced in activated human B lymphocytes and the insect cell lines SF 21 and Schneider S2. AR reversibly inhibits retinol- and 14-HRR-dependent effects and blocks B lymphocyte proliferation as well as activation of resting T lymphocytes. The intracellular signaling pathway blocked by AR in T cell activation is distinct from the calcineurin/interleukin 2 pathway inhibitable by cyclosporine A or FK-506.

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CITATIONS

97 Total citations

5 Recent citations

n/a Field Citation Ratio

1.82 Relative Citation Ratio

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GOST |

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GOST Copy

Buck J. et al. Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology. // Journal of Experimental Medicine. 1993. Vol. 178. No. 2. pp. 675-680.

GOST all authors (up to 50) Copy

Buck J., Grün F., Derguini F., Chen Y., Kimura S., Noy N., Hammerling U. Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology. // Journal of Experimental Medicine. 1993. Vol. 178. No. 2. pp. 675-680.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1084/jem.178.2.675

UR - https://doi.org/10.1084/jem.178.2.675

TI - Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.

T2 - Journal of Experimental Medicine

AU - Buck, J

AU - Grün, F

AU - Derguini, F

AU - Chen, Y.

AU - Kimura, S.

AU - Noy, N

AU - Hammerling, U.

PY - 1993

DA - 1993/08/01

PB - Rockefeller University Press

SP - 675-680

IS - 2

VL - 178

PMID - 8340762

SN - 0022-1007

SN - 1540-9538

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{1993_Buck,

author = {J Buck and F Grün and F Derguini and Y. Chen and S. Kimura and N Noy and U. Hammerling},

title = {Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.},

journal = {Journal of Experimental Medicine},

year = {1993},

volume = {178},

publisher = {Rockefeller University Press},

month = {aug},

url = {https://doi.org/10.1084/jem.178.2.675},

number = {2},

pages = {675--680},

doi = {10.1084/jem.178.2.675}

}

MLA

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MLA Copy

Buck, J., et al. “Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology..” Journal of Experimental Medicine, vol. 178, no. 2, Aug. 1993, pp. 675-680. https://doi.org/10.1084/jem.178.2.675.

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Publisher

Rockefeller University Press

Journal

Journal of Experimental Medicine

scimago Q1

wos Q1

SJR

6.838

CiteScore

26.6

Impact factor

12.6

ISSN

00221007 (Print)

15409538 (Electronic)