Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells.
Publication type: Journal Article
Publication date: 1993-12-01
scimago Q1
wos Q1
SJR: 5.834
CiteScore: 22.1
Impact factor: 10.6
ISSN: 00221007, 15409538
PubMed ID:
8245778
Immunology
Immunology and Allergy
Abstract
Vitamin A (retinol) is a prohormone that exerts its pleiotropic biological effects after conversion into multiple metabolites. In this report we describe the identification of three endogenous, retinolderived effector molecules, 14-hydroxy-retro-retinol (14-HRR), anhydroretinol (AR), and retinoic acid (RA) and a putative storage form of retinol, retinylesters (RE) in the human promyelocytic leukemia cell line HL-60. Exogenous application of the retinol metabolites in retinol-depleted serum-free cultures of HL-60 allowed the identification of unique cellular functions for each metabolite: 14-HRR is a growth factor for HL-60. AR is a functional antagonist of 14-HRR with growth-inhibiting activity, and RA is a potent inducer of granulocyte differentiation accompanied by growth arrest. Finally, intracellular RE serves as storage form allowing continuous production of 14-HRR when no external retinol is available.
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GOST
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Eppinger T. M., Buck J., Hammerling U. Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells. // Journal of Experimental Medicine. 1993. Vol. 178. No. 6. pp. 1995-2005.
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Eppinger T. M., Buck J., Hammerling U. Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells. // Journal of Experimental Medicine. 1993. Vol. 178. No. 6. pp. 1995-2005.
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RIS
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TY - JOUR
DO - 10.1084/jem.178.6.1995
UR - https://doi.org/10.1084/jem.178.6.1995
TI - Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells.
T2 - Journal of Experimental Medicine
AU - Eppinger, T M
AU - Buck, J
AU - Hammerling, U.
PY - 1993
DA - 1993/12/01
PB - Rockefeller University Press
SP - 1995-2005
IS - 6
VL - 178
PMID - 8245778
SN - 0022-1007
SN - 1540-9538
ER -
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BibTex (up to 50 authors)
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@article{1993_Eppinger,
author = {T M Eppinger and J Buck and U. Hammerling},
title = {Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells.},
journal = {Journal of Experimental Medicine},
year = {1993},
volume = {178},
publisher = {Rockefeller University Press},
month = {dec},
url = {https://doi.org/10.1084/jem.178.6.1995},
number = {6},
pages = {1995--2005},
doi = {10.1084/jem.178.6.1995}
}
Cite this
MLA
Copy
Eppinger, T. M., et al. “Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells..” Journal of Experimental Medicine, vol. 178, no. 6, Dec. 1993, pp. 1995-2005. https://doi.org/10.1084/jem.178.6.1995.