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Process Optimization of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate

Wen Long Xu
Cui Juan Guo
Tao Li
Si-Quan Liu
Тип публикацииJournal Article
Дата публикации2018-07-12
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ISSN17578981, 1757899X
General Medicine
Краткое описание
Methyl 2-methoxy-5-aminosulfonyl benzoate as an intermediate of sulpiride was synthesized from salicylic acid as precursor, which generally consisted of four reactive steps as to etherification, sulfonyl chloride, amine and lipid. Here in, after optimization of reaction conditions such as molar ratio, reaction time and reaction temperature, the yield of the four-step reactions can be improved as to 92.6% (etherification), 95.7% (sulfonyl chloride), 75.8% (amine) and 97.4%(esterification), respectively, which resulted to the efficient improvement of total yield (63.7%). The structures and purity of all synthesized compounds was confirmed by 1HNMR and HPLC.
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Xu W. L. et al. Process Optimization of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate // IOP Conference Series: Materials Science and Engineering. 2018. Vol. 382. p. 22064.
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Xu W. L., Guo C. J., Li T., Liu S. Process Optimization of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate // IOP Conference Series: Materials Science and Engineering. 2018. Vol. 382. p. 22064.
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TY - JOUR
DO - 10.1088/1757-899x/382/2/022064
UR - https://doi.org/10.1088/1757-899x/382/2/022064
TI - Process Optimization of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate
T2 - IOP Conference Series: Materials Science and Engineering
AU - Xu, Wen Long
AU - Guo, Cui Juan
AU - Li, Tao
AU - Liu, Si-Quan
PY - 2018
DA - 2018/07/12
PB - IOP Publishing
SP - 22064
VL - 382
SN - 1757-8981
SN - 1757-899X
ER -
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@article{2018_Xu,
author = {Wen Long Xu and Cui Juan Guo and Tao Li and Si-Quan Liu},
title = {Process Optimization of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate},
journal = {IOP Conference Series: Materials Science and Engineering},
year = {2018},
volume = {382},
publisher = {IOP Publishing},
month = {jul},
url = {https://doi.org/10.1088/1757-899x/382/2/022064},
pages = {22064},
doi = {10.1088/1757-899x/382/2/022064}
}