Gold nanoparticle-based nanoprobes with enhanced tumor targeting and photothermal/photodynamic response for therapy of osteosarcoma
Shengren Xiong
1
,
Guosheng Xiong
1
,
Zhaohui Li
1
,
Jiang Qing
2
,
Jia Yin
3
,
Ting Yin
4
,
Hong Zheng
1
2
Fuzhou Traditional Chinese Medicine Hospital, Fuzhou, Fujian 350001, People's Republic of China.
|
Publication type: Journal Article
Publication date: 2021-01-25
scimago Q2
wos Q2
SJR: 0.597
CiteScore: 6.2
Impact factor: 2.8
ISSN: 09574484, 13616528
PubMed ID:
33395672
General Chemistry
General Materials Science
Electrical and Electronic Engineering
Mechanical Engineering
Bioengineering
Mechanics of Materials
Abstract
Abastract
Plasmonic nanomaterials, especially a wide variety of gold nanoparticles, demonstrate great potential for theranostics of cancer. Herein, a gold nanotriangle with CD133 and hyaluronic acid on its surface loaded with a near-infrared photosensitizer was prepared for enhanced photodynamic/photothermal combined anti-tumor therapy. CD133 and hyaluronic acid provide the nanoprobe with dual tumor targeting, while the hyaluronic acid also protects photosensitive drugs from photodegradation. Thus, the nanoprobe has enhanced photothermal/photodynamic effects. This integrated treatment strategy significantly enhanced photodynamic/photothermal destruction of osteosarcoma cells. In addition, this treatment, induced by mild irradiation with a single wavelength laser, inhibited tumor growth in an osteosarcoma mouse model. These results indicate that this systemic treatment strategy can achieve enhanced anti-tumor therapeutic effects through active tumor targeting and protection of the loaded drugs.
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Total citations:
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Citations from 2024:
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(34.61%)
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MLA
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GOST
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Xiong S. et al. Gold nanoparticle-based nanoprobes with enhanced tumor targeting and photothermal/photodynamic response for therapy of osteosarcoma // Nanotechnology. 2021. Vol. 32. No. 15. p. 155102.
GOST all authors (up to 50)
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Xiong S., Xiong G., Li Z., Qing J., Yin J., Yin T., Zheng H. Gold nanoparticle-based nanoprobes with enhanced tumor targeting and photothermal/photodynamic response for therapy of osteosarcoma // Nanotechnology. 2021. Vol. 32. No. 15. p. 155102.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1088/1361-6528/abd816
UR - https://doi.org/10.1088/1361-6528/abd816
TI - Gold nanoparticle-based nanoprobes with enhanced tumor targeting and photothermal/photodynamic response for therapy of osteosarcoma
T2 - Nanotechnology
AU - Xiong, Shengren
AU - Xiong, Guosheng
AU - Li, Zhaohui
AU - Qing, Jiang
AU - Yin, Jia
AU - Yin, Ting
AU - Zheng, Hong
PY - 2021
DA - 2021/01/25
PB - IOP Publishing
SP - 155102
IS - 15
VL - 32
PMID - 33395672
SN - 0957-4484
SN - 1361-6528
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Xiong,
author = {Shengren Xiong and Guosheng Xiong and Zhaohui Li and Jiang Qing and Jia Yin and Ting Yin and Hong Zheng},
title = {Gold nanoparticle-based nanoprobes with enhanced tumor targeting and photothermal/photodynamic response for therapy of osteosarcoma},
journal = {Nanotechnology},
year = {2021},
volume = {32},
publisher = {IOP Publishing},
month = {jan},
url = {https://doi.org/10.1088/1361-6528/abd816},
number = {15},
pages = {155102},
doi = {10.1088/1361-6528/abd816}
}
Cite this
MLA
Copy
Xiong, Shengren, et al. “Gold nanoparticle-based nanoprobes with enhanced tumor targeting and photothermal/photodynamic response for therapy of osteosarcoma.” Nanotechnology, vol. 32, no. 15, Jan. 2021, p. 155102. https://doi.org/10.1088/1361-6528/abd816.