Laser Physics Letters, volume 14, issue 6, pages 65603

Noninvasive control of the transport function of fluorescent coloured liposomal nanoparticles

Stelmashchuk O
Zherebtsov E
Dunaev A.
Vinokurov A.
Bykov A.
Meglinski I.
Zherebtsova A 1
Kuznetsova E 1
Mamoshin A 1
Snimshchikova I 1
Borsukov A 3
Bykov Alexander V. 4, 5, 6
Publication typeJournal Article
Publication date2017-05-08
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor1.7
ISSN16122011, 1612202X
Physics and Astronomy (miscellaneous)
Instrumentation
Abstract
The use of liposomal nanoparticles with an incorporated active substance is an innovative and promising approach to diagnostics and therapy. The application of liposomal nanoparticle-based drugs allows for targeted localized delivery, overcomes the natural barriers within the body effectively, and minimizes possible side effects. Liposomes are able to contain a variety of ingredients with practically no limitations to their chemical composition, chemical properties, or size of constituent molecules. This study evaluated the ability to control the passage of fluorescent dye-filled liposomes through the intestinal mucosal barrier after oral administration. For this purpose, the increase in transcutaneous registered fluorescence from tetrabromofluorescein dye was recorded and analysed. Fluorescence intensity was measured at the proximal end of the tail of an animal model after oral administration of the liposomes. Measurements were taken at the excitation wavelengths of 365 and 450 nm. The fluorescence intensity in the group treated with the fluorescent contrast agent encapsulated in liposomal particles increased 140% of the initial level, but in the group treated with pure contrast agent, the increase in detected fluorescence intensity did not exceed 110%. Mice that received empty liposomes as well as the control group did not demonstrate statistically significant changes in fluorescence intensity. A potential application of our results is an express laser optical method of monitoring the transport of orally administered liposomal particles. The results can be used to help create new optical tools for use in the development of new drugs and in high-throughput screening used during their testing.

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Stelmashchuk O. et al. Noninvasive control of the transport function of fluorescent coloured liposomal nanoparticles // Laser Physics Letters. 2017. Vol. 14. No. 6. p. 65603.
GOST all authors (up to 50) Copy
Zherebtsov E., Vinokurov A., Dunaev A., Bykov A., Meglinski I., Stelmashchuk O., Stelmashchuk O., Zherebtsov E. A., Zherebtsova A., Kuznetsova E., Vinokurov A. Y., Dunaev A. V., Mamoshin A., Snimshchikova I., Borsukov A., Bykov A. V., Meglinski I. Noninvasive control of the transport function of fluorescent coloured liposomal nanoparticles // Laser Physics Letters. 2017. Vol. 14. No. 6. p. 65603.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1088/1612-202X/aa6ef5
UR - https://doi.org/10.1088%2F1612-202X%2Faa6ef5
TI - Noninvasive control of the transport function of fluorescent coloured liposomal nanoparticles
T2 - Laser Physics Letters
AU - Stelmashchuk, O
AU - Zherebtsov, E
AU - Vinokurov, A.
AU - Dunaev, A.
AU - Bykov, A.
AU - Meglinski, I.
AU - Zherebtsova, A
AU - Snimshchikova, I
AU - Borsukov, A
AU - Stelmashchuk, Olga
AU - Zherebtsov, Evgeny A.
AU - Kuznetsova, E
AU - Vinokurov, Andrey Y.
AU - Dunaev, Andrey V.
AU - Mamoshin, A
AU - Bykov, Alexander V.
AU - Meglinski, Igor
PY - 2017
DA - 2017/05/08 00:00:00
PB - IOP Publishing
SP - 65603
IS - 6
VL - 14
SN - 1612-2011
SN - 1612-202X
ER -
BibTex |
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BibTex Copy
@article{2017_Stelmashchuk
author = {O Stelmashchuk and E Zherebtsov and A. Vinokurov and A. Dunaev and A. Bykov and I. Meglinski and A Zherebtsova and I Snimshchikova and A Borsukov and Olga Stelmashchuk and Evgeny A. Zherebtsov and E Kuznetsova and Andrey Y. Vinokurov and Andrey V. Dunaev and A Mamoshin and Alexander V. Bykov and Igor Meglinski},
title = {Noninvasive control of the transport function of fluorescent coloured liposomal nanoparticles},
journal = {Laser Physics Letters},
year = {2017},
volume = {14},
publisher = {IOP Publishing},
month = {may},
url = {https://doi.org/10.1088%2F1612-202X%2Faa6ef5},
number = {6},
pages = {65603},
doi = {10.1088/1612-202X/aa6ef5}
}
MLA
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MLA Copy
Stelmashchuk, O., et al. “Noninvasive control of the transport function of fluorescent coloured liposomal nanoparticles.” Laser Physics Letters, vol. 14, no. 6, May. 2017, p. 65603. https://doi.org/10.1088%2F1612-202X%2Faa6ef5.
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