A comprehensive overview of Infinium HumanMethylation450 data processing
Publication type: Journal Article
Publication date: 2013-08-29
scimago Q1
wos Q1
SJR: 2.390
CiteScore: 15.8
Impact factor: 7.7
ISSN: 14675463, 14774054
PubMed ID:
23990268
Molecular Biology
Information Systems
Abstract
Infinium HumanMethylation450 beadarray is a popular technology to explore DNA methylomes in health and disease, and there is a current explosion in the use of this technique. Despite experience acquired from gene expression microarrays, analyzing Infinium Methylation arrays appeared more complex than initially thought and several difficulties have been encountered, as those arrays display specific features that need to be taken into consideration during data processing. Here, we review several issues that have been highlighted by the scientific community, and we present an overview of the general data processing scheme and an evaluation of the different normalization methods available to date to guide the 450K users in their analysis and data interpretation.
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Total citations:
180
Citations from 2024:
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(13.89%)
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GOST
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Dedeurwaerder S. et al. A comprehensive overview of Infinium HumanMethylation450 data processing // Briefings in Bioinformatics. 2013. Vol. 15. No. 6. pp. 929-941.
GOST all authors (up to 50)
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Dedeurwaerder S., Defrance M., Bizet M., Calonne E., Bontempi G., Fuks F. A comprehensive overview of Infinium HumanMethylation450 data processing // Briefings in Bioinformatics. 2013. Vol. 15. No. 6. pp. 929-941.
Cite this
RIS
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TY - JOUR
DO - 10.1093/bib/bbt054
UR - https://doi.org/10.1093/bib/bbt054
TI - A comprehensive overview of Infinium HumanMethylation450 data processing
T2 - Briefings in Bioinformatics
AU - Dedeurwaerder, S
AU - Defrance, Matthieu
AU - Bizet, M
AU - Calonne, Emilie
AU - Bontempi, G.
AU - Fuks, François
PY - 2013
DA - 2013/08/29
PB - Oxford University Press
SP - 929-941
IS - 6
VL - 15
PMID - 23990268
SN - 1467-5463
SN - 1477-4054
ER -
Cite this
BibTex (up to 50 authors)
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@article{2013_Dedeurwaerder,
author = {S Dedeurwaerder and Matthieu Defrance and M Bizet and Emilie Calonne and G. Bontempi and François Fuks},
title = {A comprehensive overview of Infinium HumanMethylation450 data processing},
journal = {Briefings in Bioinformatics},
year = {2013},
volume = {15},
publisher = {Oxford University Press},
month = {aug},
url = {https://doi.org/10.1093/bib/bbt054},
number = {6},
pages = {929--941},
doi = {10.1093/bib/bbt054}
}
Cite this
MLA
Copy
Dedeurwaerder, S., et al. “A comprehensive overview of Infinium HumanMethylation450 data processing.” Briefings in Bioinformatics, vol. 15, no. 6, Aug. 2013, pp. 929-941. https://doi.org/10.1093/bib/bbt054.