Synthesis of a novel fluorinated benzo[a]pyrene: 4,5-difluorobenzo [a] pyrene
1
Environmental Health Research and Testing Inc., Research Triangle Park, NC 27709.
2
Carcinogenesis and Metabolism Branch, Health Effects Research Laboratory, US Environmental Protection AgencyResearch Triangle Park, NC 2771 1, USA
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Publication type: Journal Article
Publication date: 1991-01-01
scimago Q1
wos Q2
SJR: 0.978
CiteScore: 7.9
Impact factor: 2.9
ISSN: 01433334, 14602180
PubMed ID:
1893523
Cancer Research
General Medicine
Abstract
The synthesis of 4,5-difluorobenzo[a]pyrene, as a fluorinated probe to investigate the involvement of the K-region in the further metabolic activation of benzo[a]pyrene metabolites, is described. Benzo[a]pyrene-4,5-dione obtained from 2,3-dichloro-5,6-dicyano-1,4-benzoquinone oxidation of cis-4,5-dihydro-4,5-dihydroxybenzo[a]pyrene was fluorinated with dimethylaminosulfur trifluoride to give 4H,5H,4,4,5,5,-tetra-fluorobenzo[a]pyrene. Defluorination using lithium aluminum hydride in tetrahydrofuran gave 4,5,-difluorobenzo[a]pyrene.
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GOST
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Agarwal S. C. et al. Synthesis of a novel fluorinated benzo[a]pyrene: 4,5-difluorobenzo [a] pyrene // Carcinogenesis. 1991. Vol. 12. No. 9. pp. 1647-1650.
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Agarwal S. C., Nesnow S. Synthesis of a novel fluorinated benzo[a]pyrene: 4,5-difluorobenzo [a] pyrene // Carcinogenesis. 1991. Vol. 12. No. 9. pp. 1647-1650.
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RIS
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TY - JOUR
DO - 10.1093/carcin/12.9.1647
UR - https://doi.org/10.1093/carcin/12.9.1647
TI - Synthesis of a novel fluorinated benzo[a]pyrene: 4,5-difluorobenzo [a] pyrene
T2 - Carcinogenesis
AU - Agarwal, Satish C
AU - Nesnow, Stephen
PY - 1991
DA - 1991/01/01
PB - Oxford University Press
SP - 1647-1650
IS - 9
VL - 12
PMID - 1893523
SN - 0143-3334
SN - 1460-2180
ER -
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BibTex (up to 50 authors)
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@article{1991_Agarwal,
author = {Satish C Agarwal and Stephen Nesnow},
title = {Synthesis of a novel fluorinated benzo[a]pyrene: 4,5-difluorobenzo [a] pyrene},
journal = {Carcinogenesis},
year = {1991},
volume = {12},
publisher = {Oxford University Press},
month = {jan},
url = {https://doi.org/10.1093/carcin/12.9.1647},
number = {9},
pages = {1647--1650},
doi = {10.1093/carcin/12.9.1647}
}
Cite this
MLA
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Agarwal, Satish C., et al. “Synthesis of a novel fluorinated benzo[a]pyrene: 4,5-difluorobenzo [a] pyrene.” Carcinogenesis, vol. 12, no. 9, Jan. 1991, pp. 1647-1650. https://doi.org/10.1093/carcin/12.9.1647.