Journal of Crohn's and Colitis

, том 15 , издание 11 , страницы 1824-1836

Association Between Inflammatory Bowel Disease and Psychiatric Morbidity and Suicide: A Swedish Nationwide Population-Based Cohort Study With Sibling Comparisons

Jonas Ludvigsson ^{1, 2, 3, 4}

Ola Olen ^{5, 6, 7}

H. Larsson ^{1, 8}

Jonas Halfvarson ⁹

Catarina Almqvist ^{1, 10}

P Lichtenstein ¹

A. Butwicka ^{1, 11, 12}

Скрыть аффилиации авторов Показать аффилиации авторов: 12 аффилиаций

Department of Medical Epidemiology and Biostatistics, Karolinska institutet, Solna, Sweden |

Department of Pediatrics, Orebro University Hospital, Orebro, Sweden |

Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, UK |

⁴

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA |

⁵

Sachs’ Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden |

⁶

Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden |

⁷

Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden |

⁸

School of Medical Sciences, Örebro University, Sweden |

⁹

Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden |

¹⁰

Pediatric Allergy and Pulmonology Unit, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden |

¹¹

Child and Adolescent Psychiatry Stockholm, Stockholm Health Care Services, Region Stockholm, Sweden |

¹²

Department of Child Psychiatry, Medical University of Warsaw, Warsaw, Poland |

Тип публикации: Journal Article

Дата публикации: 2021-02-27

Oxford University Press

Journal of Crohn's and Colitis

scimago Q1

wos Q1

БС1

SJR: 2.991

CiteScore: 15.6

Impact factor: 8.7

ISSN: 18739946, 18764479

DOI: 10.1093/ecco-jcc/jjab039

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PubMed ID: 33640971

General Medicine

Gastroenterology

Краткое описание

Background and Aims

Inflammatory bowel disease [IBD] is linked to psychiatric morbidity, but few studies have assessed general population comparators. We aimed to investigate the risk of psychiatric morbidity and suicide in adult-onset IBD patients.

Methods

We used a nationwide population-based cohort study in Sweden [1973–2013]. We studied the risk of psychiatric disorders and suicide in 69,865 adult-onset IBD patients [ulcerative colitis, UC: n = 43,557; Crohn’s disease, CD: n = 21,245; and IBD-unclassified: n = 5063] compared to 3,472,913 general population references and 66 292 siblings.

Results

During a median follow-up of 11 years, we found 7465 [10.7%] first psychiatric disorders in IBD [incidence rate, IR/1000 person-years 8.4] and 306 911 [9.9%] in the general population [IR 6.6], resulting in 1.8 extra psychiatric morbidity per 100 patients followed-up for 10 years and a hazard ratio [HR] of 1.3 [95% confidence interval, 95%CI = 1.2–1.3]. The highest risk of overall psychiatric morbidity was seen in the first year after IBD diagnosis [HR = 1.4, 95%CI = 1.2–1.6] and in patients with extraintestinal manifestations [HR = 1.6, 95%CI = 1.5–1.7]. Psychiatric morbidity was more common in all IBD subtypes [HR 1.3–1.5]. An increased risk of suicide attempts was observed among all IBD types [HR = 1.2–1.4], whereas completed suicide was explicitly associated with CD [HR = 1.5] and elderly-onset [diagnosed at the age of > 60 years] IBD [HR = 1.7].

Conclusion

Adult-onset IBD was associated with an increased risk of psychiatric disorders and suicide attempts. Psychological follow-up should be provided to patients with IBD, especially those with extraintestinal manifestations and elderly-onset IBD. This follow-up should be within the first year after IBD diagnosis.

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Ludvigsson J. et al. Association Between Inflammatory Bowel Disease and Psychiatric Morbidity and Suicide: A Swedish Nationwide Population-Based Cohort Study With Sibling Comparisons // Journal of Crohn's and Colitis. 2021. Vol. 15. No. 11. pp. 1824-1836.

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Ludvigsson J., Olen O., Larsson H., Halfvarson J., Almqvist C., Lichtenstein P., Butwicka A. Association Between Inflammatory Bowel Disease and Psychiatric Morbidity and Suicide: A Swedish Nationwide Population-Based Cohort Study With Sibling Comparisons // Journal of Crohn's and Colitis. 2021. Vol. 15. No. 11. pp. 1824-1836.

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TY - JOUR

DO - 10.1093/ecco-jcc/jjab039

UR - https://doi.org/10.1093/ecco-jcc/jjab039

TI - Association Between Inflammatory Bowel Disease and Psychiatric Morbidity and Suicide: A Swedish Nationwide Population-Based Cohort Study With Sibling Comparisons

T2 - Journal of Crohn's and Colitis

AU - Ludvigsson, Jonas

AU - Olen, Ola

AU - Larsson, H.

AU - Halfvarson, Jonas

AU - Almqvist, Catarina

AU - Lichtenstein, P

AU - Butwicka, A.

PY - 2021

DA - 2021/02/27

PB - Oxford University Press

SP - 1824-1836

IS - 11

VL - 15

PMID - 33640971

SN - 1873-9946

SN - 1876-4479

ER -

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@article{2021_Ludvigsson,

author = {Jonas Ludvigsson and Ola Olen and H. Larsson and Jonas Halfvarson and Catarina Almqvist and P Lichtenstein and A. Butwicka},

title = {Association Between Inflammatory Bowel Disease and Psychiatric Morbidity and Suicide: A Swedish Nationwide Population-Based Cohort Study With Sibling Comparisons},

journal = {Journal of Crohn's and Colitis},

year = {2021},

volume = {15},

publisher = {Oxford University Press},

month = {feb},

url = {https://doi.org/10.1093/ecco-jcc/jjab039},

number = {11},

pages = {1824--1836},

doi = {10.1093/ecco-jcc/jjab039}

}

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Ludvigsson, Jonas, et al. “Association Between Inflammatory Bowel Disease and Psychiatric Morbidity and Suicide: A Swedish Nationwide Population-Based Cohort Study With Sibling Comparisons.” Journal of Crohn's and Colitis, vol. 15, no. 11, Feb. 2021, pp. 1824-1836. https://doi.org/10.1093/ecco-jcc/jjab039.

Издатель

Oxford University Press

Журнал

Journal of Crohn's and Colitis

scimago Q1

wos Q1

БС1

SJR

2.991

CiteScore

15.6

Impact factor

8.7

ISSN

18739946 (Print)

18764479 (Electronic)