Mental health status and quality-of-life after an acute myocardial infarction with non-obstructive coronary arteries or takotsubo syndrome: A systematic review

Philip Leissner 1, 2
Erik Olsson 1, 2
Elisabet Rondung 3, 4
Runa Sundelin 5
Jonas Spaak 6
Anders Ulvenstam 7
Anna Nordenskjöld 8
Lena Kövamees 9, 10
Patrik Lyngå 5
Claes Held 11, 12, 13
Per Tornvall 5
Sophia Monica Humphries 14
Тип публикацииJournal Article
Дата публикации2025-02-25
scimago Q1
wos Q1
БС1
SJR2.119
CiteScore13.9
Impact factor7.5
ISSN20474873, 20474881
Краткое описание
Background

Myocardial infarction with non-obstructive coronary arteries (MINOCA) and takotsubo syndrome (TS) are both characterised by lack of significant coronary artery stenoses and a higher prevalence of mental health disorders preceding the event. Currently, little is known about their pathological aetiologies and subsequent treatment plans, giving cause for concern among those affected. The objective of this review is to provide a comprehensive overview of mental health status and quality of life (QoL) in MINOCA- and TS-patients after the acute event, compared to both cardiac and non-cardiac populations, and over time.

Methods

A systematic search was conducted via Cochrane Library, CINAHL, PyschINFO, PubMed, ASSIA, Web of Science, Scopus and Embase from inception to May 2024. The review was registered in PROSPERO and methods, and results were reported in accordance with the PRISMA guidelines. Quality assessment and risk of bias were evaluated using the Newcastle-Ottawa Scale for cross-sectional and cohort studies.

Results

Sample sizes ranged from 13 to 5,322 participants. The risk of bias was high in 18/28, medium in 7/28, and low in 3/28 studies. Across the symptoms assessed, MINOCA- and TS-patients reported worse mental health status or QoL than non-cardiac groups in 10/13 studies, and cardiac groups in 10/20 studies. Investigating change over time, 1/5 studies found deteriorating mental health status, 3/5 reported improved mental health status or QoL and 1/5 reported no change in MINOCA- and TS-patients.

Conclusions

Patients with MINOCA or TS seem to have worse mental health status and QoL after the acute event than non-cardiac individuals, but it is yet difficult to conclude whether mental distress and QoL are equal or worse compared to CHD-patients. There is no convincing evidence that mental health status or QoL of MINOCA- and TS- patients naturally improve over time after the acute event. Among the studies evaluated, risk of bias was high. More high-quality studies are needed, investigating mental health status and QoL among MINOCA- and TS-patients.

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European Journal of Preventive Cardiology
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Journal of Multidisciplinary Healthcare
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Oxford University Press
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Taylor & Francis
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Leissner P. et al. Mental health status and quality-of-life after an acute myocardial infarction with non-obstructive coronary arteries or takotsubo syndrome: A systematic review // European Journal of Preventive Cardiology. 2025.
ГОСТ со всеми авторами (до 50) Скопировать
Leissner P., Olsson E., Rondung E., Sundelin R., Spaak J., Ulvenstam A., Nordenskjöld A., Kövamees L., Lyngå P., Held C., Tornvall P., Humphries S. M. Mental health status and quality-of-life after an acute myocardial infarction with non-obstructive coronary arteries or takotsubo syndrome: A systematic review // European Journal of Preventive Cardiology. 2025.
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TY - JOUR
DO - 10.1093/eurjpc/zwaf101
UR - https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwaf101/8042361
TI - Mental health status and quality-of-life after an acute myocardial infarction with non-obstructive coronary arteries or takotsubo syndrome: A systematic review
T2 - European Journal of Preventive Cardiology
AU - Leissner, Philip
AU - Olsson, Erik
AU - Rondung, Elisabet
AU - Sundelin, Runa
AU - Spaak, Jonas
AU - Ulvenstam, Anders
AU - Nordenskjöld, Anna
AU - Kövamees, Lena
AU - Lyngå, Patrik
AU - Held, Claes
AU - Tornvall, Per
AU - Humphries, Sophia Monica
PY - 2025
DA - 2025/02/25
PB - Oxford University Press
SN - 2047-4873
SN - 2047-4881
ER -
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@article{2025_Leissner,
author = {Philip Leissner and Erik Olsson and Elisabet Rondung and Runa Sundelin and Jonas Spaak and Anders Ulvenstam and Anna Nordenskjöld and Lena Kövamees and Patrik Lyngå and Claes Held and Per Tornvall and Sophia Monica Humphries},
title = {Mental health status and quality-of-life after an acute myocardial infarction with non-obstructive coronary arteries or takotsubo syndrome: A systematic review},
journal = {European Journal of Preventive Cardiology},
year = {2025},
publisher = {Oxford University Press},
month = {feb},
url = {https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwaf101/8042361},
doi = {10.1093/eurjpc/zwaf101}
}