Genome-wide association study identifies multiple loci associated with bladder cancer risk
Jonine D. Figueroa
,
Yuanqing Ye
,
Afshan Siddiq
,
Montserrat Garcia-Closas
,
Nilanjan Chatterjee
,
Ludmila Prokunina-Olsson
,
Victoria K. Cortessis
,
O. Cussenot
,
S Benhamou
,
Jennifer Prescott
,
Stefano Porru
,
Colin P.N. Dinney
,
Nuria Malats
,
Dalsu Baris
,
Mark P. Purdue
,
E J Jacobs
,
Demetrius Albanes
,
Xiang Deng
,
Charles C. Chung
,
Wei Tang
,
H Bas Bueno de Mesquita
,
DIMITRIOS TRICHOPOULOS
,
Borje Ljungberg
,
Françoise Clavel-Chapelon
,
V Krogh
,
Miren Dorronsoro
,
Ruth C. Travis
,
Anne Tjønneland
,
Paul Brenan
,
Jenny Chang-claude
,
Elio Riboli
,
David V. Conti
,
Manuela Gago-Dominguez
,
Mariana C. Stern
,
Malcolm C. Pike
,
David Van Den Berg
,
Jian Yuan
,
Chancellor Hohensee
,
Rebecca Rodabough
,
Geraldine Cancel-Tassin
,
Morgan Rouprêt
,
E. Compérat
,
Constance Chen
,
Immaculata De Vivo
,
EDWARD GIOVANNUCCI
,
David M. Hunter
,
Peter Kraft
,
Sara Lindström
,
Angela Carta
,
Sofia Pavanello
,
Cecilia Arici
,
Giuseppe Mastrangelo
,
Ashish M. Kamat
,
Seth P. Lerner
,
H. Barton Grossman
,
Yongsheng Liu
,
Jian-Ping Gu
,
Xia Pu
,
Amy K. Hutchinson
,
Laurie Burdette
,
William Wheeler
,
Adonina Tardón
,
Consol Serra
,
Alfredo Carrato
,
Reina Garcia-Closas
,
Josep Lloreta
,
Molly Schwenn
,
Margaret R. Karagas
,
Alison Johnson
,
Alan Schned
,
Karla Armenti
,
G M Hosain
,
Gerald L. Andriole
,
Robert L. Grubb
,
Amanda Black
,
W. Ryan Diver
,
Susan M. Gapstur
,
S L Weinstein
,
Jarmo Virtamo
,
Christopher Haiman
,
M T Landi
,
Neil Caporaso
,
Joseph F. Fraumeni
,
Xifeng Wu
,
Debra T. Silverman
,
STEPHEN CHANOCK
,
Nathaniel Rothman
Publication type: Journal Article
Publication date: 2013-10-24
scimago Q1
wos Q2
SJR: 1.560
CiteScore: 7.0
Impact factor: 3.2
ISSN: 09646906, 14602083, 10672389
PubMed ID:
24163127
Molecular Biology
General Medicine
Genetics
Genetics (clinical)
Abstract
Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 × 10(-5) was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 × 10(-9)) and rs907611 on 11p15.5 (P = 4.11 × 10(-8)). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 × 10(-7)) and rs4510656 on 6p22.3 (P = 6.98 × 10(-7)); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis.
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Total citations:
136
Citations from 2024:
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(13.23%)
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GOST
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Figueroa J. D. et al. Genome-wide association study identifies multiple loci associated with bladder cancer risk // Human Molecular Genetics. 2013. Vol. 23. No. 5. pp. 1387-1398.
GOST all authors (up to 50)
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Figueroa J. D. et al. Genome-wide association study identifies multiple loci associated with bladder cancer risk // Human Molecular Genetics. 2013. Vol. 23. No. 5. pp. 1387-1398.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1093/hmg/ddt519
UR - https://doi.org/10.1093/hmg/ddt519
TI - Genome-wide association study identifies multiple loci associated with bladder cancer risk
T2 - Human Molecular Genetics
AU - Figueroa, Jonine D.
AU - Ye, Yuanqing
AU - Siddiq, Afshan
AU - Garcia-Closas, Montserrat
AU - Chatterjee, Nilanjan
AU - Prokunina-Olsson, Ludmila
AU - Cortessis, Victoria K.
AU - Kooperberg, Charles
AU - Cussenot, O.
AU - Benhamou, S
AU - Prescott, Jennifer
AU - Porru, Stefano
AU - Dinney, Colin P.N.
AU - Malats, Nuria
AU - Baris, Dalsu
AU - Purdue, Mark P.
AU - Jacobs, E J
AU - Albanes, Demetrius
AU - Wang, Zhao-Ming
AU - Deng, Xiang
AU - Chung, Charles C.
AU - Tang, Wei
AU - Bas Bueno de Mesquita, H
AU - TRICHOPOULOS, DIMITRIOS
AU - Ljungberg, Borje
AU - Clavel-Chapelon, Françoise
AU - Dobson, Annette J.
AU - Krogh, V
AU - Dorronsoro, Miren
AU - Travis, Ruth C.
AU - Tjønneland, Anne
AU - Brenan, Paul
AU - Chang-claude, Jenny
AU - Riboli, Elio
AU - Conti, David V.
AU - Gago-Dominguez, Manuela
AU - Stern, Mariana C.
AU - Pike, Malcolm C.
AU - Van Den Berg, David
AU - Yuan, Jian
AU - Hohensee, Chancellor
AU - Rodabough, Rebecca
AU - Cancel-Tassin, Geraldine
AU - Rouprêt, Morgan
AU - Compérat, E.
AU - Chen, Constance
AU - De Vivo, Immaculata
AU - GIOVANNUCCI, EDWARD
AU - Hunter, David M.
AU - Kraft, Peter
AU - Lindström, Sara
AU - Carta, Angela
AU - Pavanello, Sofia
AU - Arici, Cecilia
AU - Mastrangelo, Giuseppe
AU - Kamat, Ashish M.
AU - Lerner, Seth P.
AU - Barton Grossman, H.
AU - Liu, Yongsheng
AU - Gu, Jian-Ping
AU - Pu, Xia
AU - Hutchinson, Amy K.
AU - Burdette, Laurie
AU - Wheeler, William
AU - Kogevinas, Manolis
AU - Tardón, Adonina
AU - Serra, Consol
AU - Carrato, Alfredo
AU - Garcia-Closas, Reina
AU - Lloreta, Josep
AU - Schwenn, Molly
AU - Karagas, Margaret R.
AU - Johnson, Alison
AU - Schned, Alan
AU - Armenti, Karla
AU - Hosain, G M
AU - Andriole, Gerald L.
AU - Grubb, Robert L.
AU - Black, Amanda
AU - Diver, W. Ryan
AU - Gapstur, Susan M.
AU - Weinstein, S L
AU - Virtamo, Jarmo
AU - Haiman, Christopher
AU - Landi, M T
AU - Caporaso, Neil
AU - Fraumeni, Joseph F.
AU - Vineis, Paolo
AU - Wu, Xifeng
AU - Silverman, Debra T.
AU - CHANOCK, STEPHEN
AU - Rothman, Nathaniel
PY - 2013
DA - 2013/10/24
PB - Oxford University Press
SP - 1387-1398
IS - 5
VL - 23
PMID - 24163127
SN - 0964-6906
SN - 1460-2083
SN - 1067-2389
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2013_Figueroa,
author = {Jonine D. Figueroa and Yuanqing Ye and Afshan Siddiq and Montserrat Garcia-Closas and Nilanjan Chatterjee and Ludmila Prokunina-Olsson and Victoria K. Cortessis and Charles Kooperberg and O. Cussenot and S Benhamou and Jennifer Prescott and Stefano Porru and Colin P.N. Dinney and Nuria Malats and Dalsu Baris and Mark P. Purdue and E J Jacobs and Demetrius Albanes and Zhao-Ming Wang and Xiang Deng and Charles C. Chung and Wei Tang and H Bas Bueno de Mesquita and DIMITRIOS TRICHOPOULOS and Borje Ljungberg and Françoise Clavel-Chapelon and Annette J. Dobson and V Krogh and Miren Dorronsoro and Ruth C. Travis and Anne Tjønneland and Paul Brenan and Jenny Chang-claude and Elio Riboli and David V. Conti and Manuela Gago-Dominguez and Mariana C. Stern and Malcolm C. Pike and David Van Den Berg and Jian Yuan and Chancellor Hohensee and Rebecca Rodabough and Geraldine Cancel-Tassin and Morgan Rouprêt and E. Compérat and Constance Chen and Immaculata De Vivo and EDWARD GIOVANNUCCI and David M. Hunter and Peter Kraft and others},
title = {Genome-wide association study identifies multiple loci associated with bladder cancer risk},
journal = {Human Molecular Genetics},
year = {2013},
volume = {23},
publisher = {Oxford University Press},
month = {oct},
url = {https://doi.org/10.1093/hmg/ddt519},
number = {5},
pages = {1387--1398},
doi = {10.1093/hmg/ddt519}
}
Cite this
MLA
Copy
Figueroa, Jonine D., et al. “Genome-wide association study identifies multiple loci associated with bladder cancer risk.” Human Molecular Genetics, vol. 23, no. 5, Oct. 2013, pp. 1387-1398. https://doi.org/10.1093/hmg/ddt519.