Inflammatory Bowel Diseases

, volume 27 , issue 8 , pages 1285-1293

The Relationship Between Symptoms of Depression and Anxiety and Disease Activity in IBD Over Time

Ruth Ann Marrie ^{1, 2, 3}

Lesley A. Graff ^{3, 4}

JOHN D. FISK ⁵

Scott B Patten ⁶

C. N. Bernstein ^{1, 3}

Hide authors affiliations Show authors affiliations: 6 affiliations

Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg, Manitoba, CANADA |

Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg, Manitoba, CANADA |

University of Manitoba IBD Clinical and Research Centre , Winnipeg, Manitoba, CANADA |

⁴

Department of Clinical Health Psychology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg, Manitoba, CANADA |

⁵

Departments of Psychiatry, Psychology & Neuroscience, and Medicine, Dalhousie University , Halifax, Nova Scotia, CANADA |

⁶

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary , Calgary, Alberta, Canada |

Publication type: Journal Article

Publication date: 2021-01-04

Oxford University Press

Inflammatory Bowel Diseases

scimago Q1

wos Q1

SJR: 1.780

CiteScore: 9.3

Impact factor: 4.3

ISSN: 10780998, 15364844

DOI: 10.1093/ibd/izaa349

Copy DOI

PubMed ID: 33393632

Immunology and Allergy

Gastroenterology

Abstract

Brackground

We aimed to examine associations between elevated symptoms of depression and anxiety and disease activity in inflammatory bowel disease (IBD). Previous findings have been inconsistent and have not accounted for variability in the courses of these conditions over time.

Methods

We followed 247 participants with IBD (153 Crohn’s disease [CD], 94 ulcerative colitis [UC]) for 3 years. Annually, participants underwent an abdominal examination, reported therapies used for IBD, and completed the Hospital Anxiety and Depression Scale (HADS) questionnaire. We evaluated associations of elevated symptoms (scores ≥11) of anxiety (HADS-A) and depression (HADS-D) with the presence of active IBD as measured using the Powell Tuck Index for UC and the Harvey-Bradshaw Disease Activity Index for CD. We employed logistic regression with generalized estimating equations, simultaneously estimating between-person and within-person effects.

Results

Of 247 participants, 15 (6.1%) had elevated symptoms of depression (HADS-D ≥11) at enrollment, 41 (16.6%) had elevated symptoms of anxiety (HADS-A ≥11), and 101 (40.9%) had active IBD. On average, individuals with elevated symptoms of depression (odds ratio [OR], 6.27; 95% CI, 1.39–28.2) and anxiety (OR, 2.17; 95% CI, 1.01–4.66) had increased odds of active IBD. Within individuals, elevations in symptoms of depression over time were associated with increased odds of active IBD (OR, 2.70; 95% CI, 1.15–6.34), but elevated symptoms of anxiety were not. After adjustment for covariates (including disease activity), elevated symptoms of depression were also associated with increased odds of biologic therapy use (OR, 2.02; 95% CI, 1.02–4.00).

Conclusion

Symptoms of depression and anxiety are associated with disease activity in IBD over time. Reducing these symptoms should be incorporated into the management of IBD.

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Cite this

GOST |

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GOST Copy

Marrie R. A. et al. The Relationship Between Symptoms of Depression and Anxiety and Disease Activity in IBD Over Time // Inflammatory Bowel Diseases. 2021. Vol. 27. No. 8. pp. 1285-1293.

GOST all authors (up to 50) Copy

Marrie R. A., Graff L. A., FISK J. D., Patten S. B., Bernstein C. N. The Relationship Between Symptoms of Depression and Anxiety and Disease Activity in IBD Over Time // Inflammatory Bowel Diseases. 2021. Vol. 27. No. 8. pp. 1285-1293.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1093/ibd/izaa349

UR - https://doi.org/10.1093/ibd/izaa349

TI - The Relationship Between Symptoms of Depression and Anxiety and Disease Activity in IBD Over Time

T2 - Inflammatory Bowel Diseases

AU - Marrie, Ruth Ann

AU - Graff, Lesley A.

AU - FISK, JOHN D.

AU - Patten, Scott B

AU - Bernstein, C. N.

PY - 2021

DA - 2021/01/04

PB - Oxford University Press

SP - 1285-1293

IS - 8

VL - 27

PMID - 33393632

SN - 1078-0998

SN - 1536-4844

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Marrie,

author = {Ruth Ann Marrie and Lesley A. Graff and JOHN D. FISK and Scott B Patten and C. N. Bernstein},

title = {The Relationship Between Symptoms of Depression and Anxiety and Disease Activity in IBD Over Time},

journal = {Inflammatory Bowel Diseases},

year = {2021},

volume = {27},

publisher = {Oxford University Press},

month = {jan},

url = {https://doi.org/10.1093/ibd/izaa349},

number = {8},

pages = {1285--1293},

doi = {10.1093/ibd/izaa349}

}

MLA

Cite this

MLA Copy

Marrie, Ruth Ann, et al. “The Relationship Between Symptoms of Depression and Anxiety and Disease Activity in IBD Over Time.” Inflammatory Bowel Diseases, vol. 27, no. 8, Jan. 2021, pp. 1285-1293. https://doi.org/10.1093/ibd/izaa349.

Publisher

Oxford University Press

Journal

Inflammatory Bowel Diseases

scimago Q1

wos Q1

SJR

1.780

CiteScore

9.3

Impact factor

4.3

ISSN

10780998 (Print)

15364844 (Electronic)