Open Access
Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients
Frauke Muecksch
1
,
Helen Wise
2
,
Becky Batchelor
2
,
Maria Squires
2
,
Elizabeth Semple
2
,
Claire Richardson
3
,
Jacqueline McGuire
3
,
Sarah Clearly
3
,
Elizabeth Furrie
4
,
Neil Greig
4
,
Gordon Hay
4
,
Kate E. Templeton
2
,
Julio C.C. Lorenzi
5
,
Theodora Hatziioannou
1
,
Sara Jenks
2
,
Paul D. Bieniasz
1, 6
3
University Hospital Monklands, NHS Lanarkshire, Airdrie, Scotland
|
Тип публикации: Journal Article
Дата публикации: 2020-11-03
scimago Q1
wos Q1
БС1
SJR: 2.038
CiteScore: 11.1
Impact factor: 4.5
ISSN: 00221899, 15376613
PubMed ID:
33140086
Infectious Diseases
Immunology and Allergy
Краткое описание
Background
Understanding the longitudinal trajectory of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is crucial for diagnosis of prior infection and predicting future immunity.
Methods
We conducted a longitudinal analysis of coronavirus disease 2019 convalescent patients, with neutralizing antibody assays and SARS-CoV-2 serological assay platforms using SARS-CoV-2 spike (S) or nucleocapsid (N) antigens.
Results
Sensitivities of serological assays in diagnosing prior SARS-CoV-2 infection changed with time. One widely used commercial platform that had an initial sensitivity of >95% declined to 71% at 81–100 days after diagnosis. The trajectories of median binding antibody titers measured over approximately 3–4 months were not dependent on the use of SARS-CoV-2 N or S proteins as antigen. The median neutralization titer decreased by approximately 45% per month. Each serological assay gave quantitative antibody titers that were correlated with SARS-CoV-2 neutralization titers, but S-based serological assay measurements better predicted neutralization potency. Correlation between S-binding and neutralization titers deteriorated with time, and decreases in neutralization titers were not predicted by changes in S-binding antibody titers.
Conclusions
Different SARS-CoV-2 serological assays are more or less well suited for surveillance versus prediction of serum neutralization potency. Extended follow-up should facilitate the establishment of appropriate serological correlates of protection against SARS-CoV-2 reinfection.
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ГОСТ
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Muecksch F. et al. Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients // Journal of Infectious Diseases. 2020. Vol. 223. No. 3. pp. 389-398.
ГОСТ со всеми авторами (до 50)
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Muecksch F., Wise H., Batchelor B., Squires M., Semple E., Richardson C., McGuire J., Clearly S., Furrie E., Greig N., Hay G., Templeton K. E., Lorenzi J. C., Hatziioannou T., Jenks S., Bieniasz P. D. Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients // Journal of Infectious Diseases. 2020. Vol. 223. No. 3. pp. 389-398.
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TY - JOUR
DO - 10.1093/infdis/jiaa659
UR - https://doi.org/10.1093/infdis/jiaa659
TI - Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients
T2 - Journal of Infectious Diseases
AU - Muecksch, Frauke
AU - Wise, Helen
AU - Batchelor, Becky
AU - Squires, Maria
AU - Semple, Elizabeth
AU - Richardson, Claire
AU - McGuire, Jacqueline
AU - Clearly, Sarah
AU - Furrie, Elizabeth
AU - Greig, Neil
AU - Hay, Gordon
AU - Templeton, Kate E.
AU - Lorenzi, Julio C.C.
AU - Hatziioannou, Theodora
AU - Jenks, Sara
AU - Bieniasz, Paul D.
PY - 2020
DA - 2020/11/03
PB - Oxford University Press
SP - 389-398
IS - 3
VL - 223
PMID - 33140086
SN - 0022-1899
SN - 1537-6613
ER -
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BibTex (до 50 авторов)
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@article{2020_Muecksch,
author = {Frauke Muecksch and Helen Wise and Becky Batchelor and Maria Squires and Elizabeth Semple and Claire Richardson and Jacqueline McGuire and Sarah Clearly and Elizabeth Furrie and Neil Greig and Gordon Hay and Kate E. Templeton and Julio C.C. Lorenzi and Theodora Hatziioannou and Sara Jenks and Paul D. Bieniasz},
title = {Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients},
journal = {Journal of Infectious Diseases},
year = {2020},
volume = {223},
publisher = {Oxford University Press},
month = {nov},
url = {https://doi.org/10.1093/infdis/jiaa659},
number = {3},
pages = {389--398},
doi = {10.1093/infdis/jiaa659}
}
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MLA
Скопировать
Muecksch, Frauke, et al. “Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients.” Journal of Infectious Diseases, vol. 223, no. 3, Nov. 2020, pp. 389-398. https://doi.org/10.1093/infdis/jiaa659.