Open Access
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study
Ivan A. Molodtsov
1
,
Evgenii Kegeles
2
,
Alexander N Mitin
3
,
Olga Mityaeva
2
,
Oksana E Musatova
4
,
Anna E. Panova
5
,
Mikhail V. Pashenkov
3
,
Iuliia O Peshkova
6
,
Almaqdad Alsalloum
2
,
Walaa Asaad
2
,
Anna S. Budikhina
3
,
Alexander S Deryabin
4
,
Ioanna N Filimonova
4
,
Alexandra N Gracheva
5
,
Oxana I Ivanova
1, 8
,
Anastasia Kizilova
2
,
Viktoria V Komogorova
3
,
Anastasia Komova
2, 9
,
Natalia I Kompantseva
5
,
Ekaterina Kucheryavykh
10
,
Denis А Lagutkin
5
,
Yakov A Lomakin
4
,
Alexandra V. Maleeva
6
,
Elena V Maryukhnich
1, 8
,
Afraa Mohammad
2
,
Vladimir V. Murugin
3
,
Nina E. Murugina
3
,
Anna Navoikova
2
,
Margarita F Nikonova
3
,
Yana Panarina
10
,
Natalia V Pinegina
1, 8
,
Daria M. Potashnikova
1, 8
,
Elizaveta V Romanova
1
,
Aleena A. Saidova
1
,
Nawar Sakr
2
,
Anastasia G. Samoilova
5
,
Yana Serdyuk
6
,
Naina T Shakirova
6
,
Nina I Sharova
3
,
Saveliy A Sheetikov
6
,
Anastasia F Shemetova
5
,
Liudmila V Shevkova
2, 9
,
Alexander V Shpektor
1, 8
,
Anna Trufanova
2
,
Anna V. Tvorogova
1
,
Valeria M Ukrainskaya
4
,
Anatoliy S Vinokurov
5
,
Daria A Vorobyeva
1, 8
,
Ksenia V Zornikova
6
,
Grigory A. Efimov
6
,
Musa R Khaitov
3, 11
,
Ilya A Kofiadi
3, 11
,
Alexey A Komissarov
1, 8
,
Denis Y. Logunov
7
,
Nelli B. Naigovzina
8
,
Yury P Rubtsov
4
,
Irina A. Vasilyeva
5
,
Pavel Volchkov
2, 9
,
Elena Vasilieva
1, 8
1
Clinical City Hospital named after I. V. Davydovsky, Moscow Department of Healthcare , Moscow , Russia
|
2
10
Government of Moscow , Moscow , Russia
|
Publication type: Journal Article
Publication date: 2022-04-12
scimago Q1
wos Q1
SJR: 2.992
CiteScore: 21.0
Impact factor: 7.3
ISSN: 10584838, 15376591
PubMed ID:
35435222
Microbiology (medical)
Infectious Diseases
Abstract
Background
During the ongoing coronavirus disease 2019 (COVID-19) pandemic, many individuals were infected with and have cleared the virus, developing virus-specific antibodies and effector/memory T cells. An important unanswered question is what levels of T-cell and antibody responses are sufficient to protect from the infection.
Methods
In 5340 Moscow residents, we evaluated anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin M (IgM)/immunoglobulin G (IgG) titers and frequencies of the T cells specific to the membrane, nucleocapsid, and spike proteins of SARS-CoV-2, using interferon gamma (IFN-γ) enzyme-linked immunosorbent spot (ELISpot) assay. Additionally, we evaluated the fractions of virus-specific CD4+ and CD8+ T cells using intracellular staining of IFN-γ and interleukin 2 followed by flow cytometry. We analyzed the COVID-19 rates as a function of the assessed antibody and T-cell responses, using the Kaplan–Meier estimator method, for up to 300 days postinclusion.
Results
We showed that T-cell and antibody responses are closely interconnected and are commonly induced concurrently. Magnitudes of both responses inversely correlated with infection probability. Individuals positive for both responses demonstrated the highest levels of protectivity against the SARS-CoV-2 infection. A comparable level of protection was found in individuals with antibody response only, whereas the T-cell response by itself granted only intermediate protection.
Conclusions
We found that the contribution of the virus-specific antibodies to protection against SARS-CoV-2 infection is more pronounced than that of the T cells. The data on the virus-specific IgG titers may be instructive for making decisions in personalized healthcare and public anti–COVID-19 policies.
Clinical Trials Registration. NCT04898140.
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Total citations:
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Citations from 2024:
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GOST
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Molodtsov I. A. et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study // Clinical Infectious Diseases. 2022. Vol. 75. No. 1. p. e1-e9.
GOST all authors (up to 50)
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Molodtsov I. A. et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study // Clinical Infectious Diseases. 2022. Vol. 75. No. 1. p. e1-e9.
Cite this
RIS
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TY - JOUR
DO - 10.1093/cid/ciac278
UR - https://doi.org/10.1093/cid/ciac278
TI - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study
T2 - Clinical Infectious Diseases
AU - Molodtsov, Ivan A.
AU - Kegeles, Evgenii
AU - Mitin, Alexander N
AU - Mityaeva, Olga
AU - Musatova, Oksana E
AU - Panova, Anna E.
AU - Pashenkov, Mikhail V.
AU - Peshkova, Iuliia O
AU - Alsalloum, Almaqdad
AU - Asaad, Walaa
AU - Budikhina, Anna S.
AU - Deryabin, Alexander S
AU - Dolzhikova, Inna V
AU - Filimonova, Ioanna N
AU - Gracheva, Alexandra N
AU - Ivanova, Oxana I
AU - Kizilova, Anastasia
AU - Komogorova, Viktoria V
AU - Komova, Anastasia
AU - Kompantseva, Natalia I
AU - Kucheryavykh, Ekaterina
AU - Lagutkin, Denis А
AU - Lomakin, Yakov A
AU - Maleeva, Alexandra V.
AU - Maryukhnich, Elena V
AU - Mohammad, Afraa
AU - Murugin, Vladimir V.
AU - Murugina, Nina E.
AU - Navoikova, Anna
AU - Nikonova, Margarita F
AU - Ovchinnikova, Leyla A
AU - Panarina, Yana
AU - Pinegina, Natalia V
AU - Potashnikova, Daria M.
AU - Romanova, Elizaveta V
AU - Saidova, Aleena A.
AU - Sakr, Nawar
AU - Samoilova, Anastasia G.
AU - Serdyuk, Yana
AU - Shakirova, Naina T
AU - Sharova, Nina I
AU - Sheetikov, Saveliy A
AU - Shemetova, Anastasia F
AU - Shevkova, Liudmila V
AU - Shpektor, Alexander V
AU - Trufanova, Anna
AU - Tvorogova, Anna V.
AU - Ukrainskaya, Valeria M
AU - Vinokurov, Anatoliy S
AU - Vorobyeva, Daria A
AU - Zornikova, Ksenia V
AU - Efimov, Grigory A.
AU - Khaitov, Musa R
AU - Kofiadi, Ilya A
AU - Komissarov, Alexey A
AU - Logunov, Denis Y.
AU - Naigovzina, Nelli B.
AU - Rubtsov, Yury P
AU - Vasilyeva, Irina A.
AU - Volchkov, Pavel
AU - Vasilieva, Elena
PY - 2022
DA - 2022/04/12
PB - Oxford University Press
SP - e1-e9
IS - 1
VL - 75
PMID - 35435222
SN - 1058-4838
SN - 1537-6591
ER -
Cite this
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@article{2022_Molodtsov,
author = {Ivan A. Molodtsov and Evgenii Kegeles and Alexander N Mitin and Olga Mityaeva and Oksana E Musatova and Anna E. Panova and Mikhail V. Pashenkov and Iuliia O Peshkova and Almaqdad Alsalloum and Walaa Asaad and Anna S. Budikhina and Alexander S Deryabin and Inna V Dolzhikova and Ioanna N Filimonova and Alexandra N Gracheva and Oxana I Ivanova and Anastasia Kizilova and Viktoria V Komogorova and Anastasia Komova and Natalia I Kompantseva and Ekaterina Kucheryavykh and Denis А Lagutkin and Yakov A Lomakin and Alexandra V. Maleeva and Elena V Maryukhnich and Afraa Mohammad and Vladimir V. Murugin and Nina E. Murugina and Anna Navoikova and Margarita F Nikonova and Leyla A Ovchinnikova and Yana Panarina and Natalia V Pinegina and Daria M. Potashnikova and Elizaveta V Romanova and Aleena A. Saidova and Nawar Sakr and Anastasia G. Samoilova and Yana Serdyuk and Naina T Shakirova and Nina I Sharova and Saveliy A Sheetikov and Anastasia F Shemetova and Liudmila V Shevkova and Alexander V Shpektor and Anna Trufanova and Anna V. Tvorogova and Valeria M Ukrainskaya and Anatoliy S Vinokurov and Daria A Vorobyeva and others},
title = {Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study},
journal = {Clinical Infectious Diseases},
year = {2022},
volume = {75},
publisher = {Oxford University Press},
month = {apr},
url = {https://doi.org/10.1093/cid/ciac278},
number = {1},
pages = {e1--e9},
doi = {10.1093/cid/ciac278}
}
Cite this
MLA
Copy
Molodtsov, Ivan A., et al. “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study.” Clinical Infectious Diseases, vol. 75, no. 1, Apr. 2022, pp. e1-e9. https://doi.org/10.1093/cid/ciac278.