Open Access
Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort
Тип публикации: Journal Article
Дата публикации: 2020-08-25
scimago Q1
wos Q1
white level БС1
SJR: 1.585
CiteScore: 9.7
Impact factor: 3.7
ISSN: 14611457, 14695111
PubMed ID:
32840607
Pharmacology
Pharmacology (medical)
Psychiatry and Mental health
Краткое описание
Background
Patients with a first episode of psychosis (FEP) are at higher risk of gaining weight and presenting metabolic disturbances, partly related to antipsychotic exposure. Previous studies suggest that treatment discontinuation might have a positive impact on weight in schizophrenia. The aim of this study was to evaluate the effect of treatment discontinuation on weight and metabolic changes in a FEP cohort.
Methods
A total of 209 FEP patients and 57 healthy controls were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric measures and, clinical, metabolic, and sociodemographic data were collected.
Results
Patients discontinuing antipsychotic treatment presented a significantly lower increase in weight and better metabolic parameter results than those still on antipsychotic treatment at 10-year follow-up.
Conclusions
Treatment discontinuation had a positive effect on the weight and metabolic changes observed in FEP patients; however, this effect was not sufficient to reaching a complete reversal to normal levels.
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ГОСТ
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Vázquez-Bourgon J. et al. Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort // International Journal of Neuropsychopharmacology. 2020. Vol. 24. No. 1. pp. 1-7.
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Vázquez-Bourgon J., Mayoral Van Son J., Gómez-Revuelta M., Juncal Ruiz M., Ortiz Garcia De La Foz V., Tordesillas Gutiérrez D., Ayesa-Arriola R., Bioque M., Crespo-Facorro B. Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort // International Journal of Neuropsychopharmacology. 2020. Vol. 24. No. 1. pp. 1-7.
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TY - JOUR
DO - 10.1093/ijnp/pyaa066
UR - https://doi.org/10.1093/ijnp/pyaa066
TI - Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort
T2 - International Journal of Neuropsychopharmacology
AU - Vázquez-Bourgon, J.
AU - Mayoral Van Son, Jaqueline
AU - Gómez-Revuelta, M.
AU - Juncal Ruiz, Maria
AU - Ortiz Garcia De La Foz, Victor
AU - Tordesillas Gutiérrez, Diana
AU - Ayesa-Arriola, Rosa
AU - Bioque, M.
AU - Crespo-Facorro, Benedicto
PY - 2020
DA - 2020/08/25
PB - Oxford University Press
SP - 1-7
IS - 1
VL - 24
PMID - 32840607
SN - 1461-1457
SN - 1469-5111
ER -
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BibTex (до 50 авторов)
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@article{2020_Vázquez-Bourgon,
author = {J. Vázquez-Bourgon and Jaqueline Mayoral Van Son and M. Gómez-Revuelta and Maria Juncal Ruiz and Victor Ortiz Garcia De La Foz and Diana Tordesillas Gutiérrez and Rosa Ayesa-Arriola and M. Bioque and Benedicto Crespo-Facorro},
title = {Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort},
journal = {International Journal of Neuropsychopharmacology},
year = {2020},
volume = {24},
publisher = {Oxford University Press},
month = {aug},
url = {https://doi.org/10.1093/ijnp/pyaa066},
number = {1},
pages = {1--7},
doi = {10.1093/ijnp/pyaa066}
}
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MLA
Скопировать
Vázquez-Bourgon, J., et al. “Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort.” International Journal of Neuropsychopharmacology, vol. 24, no. 1, Aug. 2020, pp. 1-7. https://doi.org/10.1093/ijnp/pyaa066.
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