Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG
Тип публикации: Journal Article
Дата публикации: 2000-12-01
scimago Q1
wos Q2
БС1
SJR: 1.209
CiteScore: 7.3
Impact factor: 3.6
ISSN: 03057453, 14602091
PubMed ID:
11102410
Pharmacology
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)
Краткое описание
Depletion of oxygen triggers the shift-down of Mycobacterium bovis BCG to a state of dormancy. Bacilli in their dormant state are resistant to standard anti-mycobacterials. The nitroimidazole metronidazole was the first compound identified to show bactericidal activity against dormant tubercle bacilli. In contrast to metronidazole's selective toxicity for dormant bacilli, we report here that the nitrofurans nitrofurantoin, furaltadone and nitrofurazone showed bactericidal activity against dormant and growing bacteria. Importantly, the bactericidal effect of nitrofurans on dormant bacilli was 35- to 250-fold higher compared with metronidazole.
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MLA
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ГОСТ
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Murugasu-Oei B. Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG // Journal of Antimicrobial Chemotherapy. 2000. Vol. 46. No. 6. pp. 917-919.
ГОСТ со всеми авторами (до 50)
Скопировать
Murugasu-Oei B. Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG // Journal of Antimicrobial Chemotherapy. 2000. Vol. 46. No. 6. pp. 917-919.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1093/jac/46.6.917
UR - https://doi.org/10.1093/jac/46.6.917
TI - Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG
T2 - Journal of Antimicrobial Chemotherapy
AU - Murugasu-Oei, B
PY - 2000
DA - 2000/12/01
PB - Oxford University Press
SP - 917-919
IS - 6
VL - 46
PMID - 11102410
SN - 0305-7453
SN - 1460-2091
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2000_Murugasu-Oei,
author = {B Murugasu-Oei},
title = {Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG},
journal = {Journal of Antimicrobial Chemotherapy},
year = {2000},
volume = {46},
publisher = {Oxford University Press},
month = {dec},
url = {https://doi.org/10.1093/jac/46.6.917},
number = {6},
pages = {917--919},
doi = {10.1093/jac/46.6.917}
}
Цитировать
MLA
Скопировать
Murugasu-Oei, B.. “Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG.” Journal of Antimicrobial Chemotherapy, vol. 46, no. 6, Dec. 2000, pp. 917-919. https://doi.org/10.1093/jac/46.6.917.