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A comparative study of the interaction of 5, 10, 15, 20-tetrakis (N- methylpyridinium-4-yl)porphyrin and its zinc complex with DNA using fluorescence spectroscopy and topoisomerisation
Publication type: Journal Article
Publication date: 1985-01-01
scimago Q1
wos Q1
SJR: 7.776
CiteScore: 31.7
Impact factor: 13.1
ISSN: 03051048, 13624962
PubMed ID:
2987789
Genetics
Abstract
Binding of 5,10,15,20-tetrakis (N-methylpyridinium-4-yl)porphyrin (H2TMPyP4+) and its zinc complex (ZnTMPyP4+) to DNA is demonstrated by their coelectrophoresis and by absorption and fluorescence spectroscopic methods. Topoisomerisation of pBR322 DNA shows that H2TMPyP4+ unwinds DNA as efficiently as ethidium bromide showing that it intercalates at many sites. ZnTMPyP4+ may cause limited unwinding. Marked changes in the fluorescence spectra of the porphyrins are found in the presence of DNA. The fluorescence intensity of either H2TMPyP4+ or ZnTMPyP4+ is enhanced in the presence of poly (d(A-T)), whereas in the presence of poly (d(G-C] the fluorescence intensity of ZnTMPyP4+ is only slightly affected and that of H2TMPyP4+ markedly reduced. Both the porphyrins photosensitize the cleavage of DNA in aerated solution upon visible light irradiation.
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Total citations:
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Kelly J. W. et al. A comparative study of the interaction of 5, 10, 15, 20-tetrakis (N- methylpyridinium-4-yl)porphyrin and its zinc complex with DNA using fluorescence spectroscopy and topoisomerisation // Nucleic Acids Research. 1985. Vol. 13. No. 1. pp. 167-184.
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Kelly J. W., Murphy M. J., McConnell D. J., Ohuigin C. A comparative study of the interaction of 5, 10, 15, 20-tetrakis (N- methylpyridinium-4-yl)porphyrin and its zinc complex with DNA using fluorescence spectroscopy and topoisomerisation // Nucleic Acids Research. 1985. Vol. 13. No. 1. pp. 167-184.
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RIS
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TY - JOUR
DO - 10.1093/nar/13.1.167
UR - https://doi.org/10.1093/nar/13.1.167
TI - A comparative study of the interaction of 5, 10, 15, 20-tetrakis (N- methylpyridinium-4-yl)porphyrin and its zinc complex with DNA using fluorescence spectroscopy and topoisomerisation
T2 - Nucleic Acids Research
AU - Kelly, John W.
AU - Murphy, Martin J.
AU - McConnell, David J.
AU - Ohuigin, Cohn
PY - 1985
DA - 1985/01/01
PB - Oxford University Press
SP - 167-184
IS - 1
VL - 13
PMID - 2987789
SN - 0305-1048
SN - 1362-4962
ER -
Cite this
BibTex (up to 50 authors)
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@article{1985_Kelly,
author = {John W. Kelly and Martin J. Murphy and David J. McConnell and Cohn Ohuigin},
title = {A comparative study of the interaction of 5, 10, 15, 20-tetrakis (N- methylpyridinium-4-yl)porphyrin and its zinc complex with DNA using fluorescence spectroscopy and topoisomerisation},
journal = {Nucleic Acids Research},
year = {1985},
volume = {13},
publisher = {Oxford University Press},
month = {jan},
url = {https://doi.org/10.1093/nar/13.1.167},
number = {1},
pages = {167--184},
doi = {10.1093/nar/13.1.167}
}
Cite this
MLA
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Kelly, John W., et al. “A comparative study of the interaction of 5, 10, 15, 20-tetrakis (N- methylpyridinium-4-yl)porphyrin and its zinc complex with DNA using fluorescence spectroscopy and topoisomerisation.” Nucleic Acids Research, vol. 13, no. 1, Jan. 1985, pp. 167-184. https://doi.org/10.1093/nar/13.1.167.