Open Access
Nucleic Acids Research, volume 44, issue 17, pages 8052-8064
Evoking picomolar binding in RNA by a single phosphorodithioate linkage
N Dinuka Abeydeera
1
,
Martin Egli
2
,
Nehemiah Cox
3
,
Karen Mercier
4
,
Jonas N Conde
5
,
Pradeep S. Pallan
2
,
Daniella M. Mizurini
6
,
Malgorzata Sierant
7
,
Fatima Ezzahra Hibti
4
,
Tom Hassell
8
,
Tianzhi Wang
9
,
Feng Wu Liu
10
,
Hong-Min Liu
10
,
Carlos Martínez
8
,
Anil K. Sood
11
,
Terry P. Lybrand
12
,
Chiraz Frydman
4
,
Robson Q. Monteiro
6
,
R. Gomer
3
,
Barbara Nawrot
7
,
Xianbin Yang
1
1
AM Biotechnologies, LLC, 12521 Gulf Freeway, Houston, TX 77034, USA
|
3
Department of Biology, Texas A&M University, College Station, TX 77843, USA.
|
4
Biointeractions Division, Horiba Scientific, Avenue de la Vauve - Passage JobinYvon CS 45002 Palaiseau, France
|
7
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90–363 Lodz, Sienkiewicza 112, Poland
|
8
MilliporeSigma, 9186 Six Pines, The Woodlands, TX 77380, USA
|
9
The Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, USA.
|
Publication type: Journal Article
Publication date: 2016-08-26
Journal:
Nucleic Acids Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 14.9
ISSN: 03051048, 13624962
Genetics
Abstract
RNA aptamers are synthetic oligonucleotide-based affinity molecules that utilize unique three-dimensional structures for their affinity and specificity to a target such as a protein. They hold the promise of numerous advantages over biologically produced antibodies; however, the binding affinity and specificity of RNA aptamers are often insufficient for successful implementation in diagnostic assays or as therapeutic agents. Strong binding affinity is important to improve the downstream applications. We report here the use of the phosphorodithioate (PS2) substitution on a single nucleotide of RNA aptamers to dramatically improve target binding affinity by ∼1000-fold (from nanomolar to picomolar). An X-ray co-crystal structure of the α-thrombin:PS2-aptamer complex reveals a localized induced-fit rearrangement of the PS2-containing nucleotide which leads to enhanced target interaction. High-level quantum mechanical calculations for model systems that mimic the PS2 moiety and phenylalanine demonstrate that an edge-on interaction between sulfur and the aromatic ring is quite favorable, and also confirm that the sulfur analogs are much more polarizable than the corresponding phosphates. This favorable interaction involving the sulfur atom is likely even more significant in the full aptamer-protein complexes than in the model systems.
Top-30
Citations by journals
1
2
3
4
5
|
|
International Journal of Molecular Sciences
5 publications, 5.38%
|
|
Nucleic Acids Research
5 publications, 5.38%
|
|
Molecules
4 publications, 4.3%
|
|
Journal of the American Chemical Society
4 publications, 4.3%
|
|
Molecular Therapy - Nucleic Acids
3 publications, 3.23%
|
|
Sensors and Actuators, B: Chemical
3 publications, 3.23%
|
|
Biochimie
3 publications, 3.23%
|
|
Current Protocols in Nucleic Acid Chemistry
3 publications, 3.23%
|
|
Pharmaceuticals
2 publications, 2.15%
|
|
Advanced Drug Delivery Reviews
2 publications, 2.15%
|
|
Analytical Chemistry
2 publications, 2.15%
|
|
Current Protocols
2 publications, 2.15%
|
|
Beilstein Journal of Organic Chemistry
1 publication, 1.08%
|
|
Current HIV Research
1 publication, 1.08%
|
|
Cancer Biotherapy and Radiopharmaceuticals
1 publication, 1.08%
|
|
Frontiers in Cell and Developmental Biology
1 publication, 1.08%
|
|
Current Opinion in Oncology
1 publication, 1.08%
|
|
Biomedicines
1 publication, 1.08%
|
|
Biomolecules
1 publication, 1.08%
|
|
Biosensors
1 publication, 1.08%
|
|
Frontiers in Molecular Biosciences
1 publication, 1.08%
|
|
Cancers
1 publication, 1.08%
|
|
Chemical Research in Chinese Universities
1 publication, 1.08%
|
|
Nature Reviews Chemistry
1 publication, 1.08%
|
|
Journal of Biosciences
1 publication, 1.08%
|
|
Scientific Reports
1 publication, 1.08%
|
|
Biotechnology Advances
1 publication, 1.08%
|
|
Trends in Biotechnology
1 publication, 1.08%
|
|
Journal of Controlled Release
1 publication, 1.08%
|
|
1
2
3
4
5
|
Citations by publishers
5
10
15
20
25
30
|
|
Elsevier
26 publications, 27.96%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
15 publications, 16.13%
|
|
American Chemical Society (ACS)
12 publications, 12.9%
|
|
Wiley
9 publications, 9.68%
|
|
Springer Nature
6 publications, 6.45%
|
|
Oxford University Press
5 publications, 5.38%
|
|
Royal Society of Chemistry (RSC)
4 publications, 4.3%
|
|
Frontiers Media S.A.
2 publications, 2.15%
|
|
Taylor & Francis
2 publications, 2.15%
|
|
Beilstein-Institut
1 publication, 1.08%
|
|
Bentham Science
1 publication, 1.08%
|
|
Mary Ann Liebert
1 publication, 1.08%
|
|
Wolters Kluwer Health
1 publication, 1.08%
|
|
Public Library of Science (PLoS)
1 publication, 1.08%
|
|
Pleiades Publishing
1 publication, 1.08%
|
|
Cold Spring Harbor Laboratory
1 publication, 1.08%
|
|
Annual Reviews
1 publication, 1.08%
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 1.08%
|
|
5
10
15
20
25
30
|
- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","",""],"datasets":[{"label":"Citations number","data":[2,7,10,12,11,12,15,16,8],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["2.15","7.53","10.75","12.9","11.83","12.9","16.13","17.2","8.6"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["International Journal of Molecular Sciences","Nucleic Acids Research","Molecules","Journal of the American Chemical Society","Molecular Therapy - Nucleic Acids","Sensors and Actuators, B: Chemical","Biochimie","Current Protocols in Nucleic Acid Chemistry","Pharmaceuticals","Advanced Drug Delivery Reviews","Analytical Chemistry","Current Protocols","Beilstein Journal of Organic Chemistry","Current HIV Research","Cancer Biotherapy and Radiopharmaceuticals","Frontiers in Cell and Developmental Biology","Current Opinion in Oncology","Biomedicines","Biomolecules","Biosensors","Frontiers in Molecular Biosciences","Cancers","Chemical Research in Chinese Universities","Nature Reviews Chemistry","Journal of Biosciences","Scientific Reports","Biotechnology Advances","Trends in Biotechnology","Journal of Controlled Release"],"ids":[14627,23904,1770,4813,20403,22419,4794,13488,1203,12266,18157,26431,21928,10789,21162,12128,9364,24421,13780,5233,3133,22471,1401,6657,2948,13767,17421,17422,14351],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/ex6KJoZujZOZFZh7jGfeHauiftuB3CI7iwJVFRDg_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[5,5,4,4,3,3,3,3,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[5.38,5.38,4.3,4.3,3.23,3.23,3.23,3.23,2.15,2.15,2.15,2.15,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","American Chemical Society (ACS)","Wiley","Springer Nature","Oxford University Press","Royal Society of Chemistry (RSC)","Frontiers Media S.A.","Taylor & Francis","Beilstein-Institut","Bentham Science","Mary Ann Liebert","Wolters Kluwer Health","Public Library of Science (PLoS)","Pleiades Publishing","Cold Spring Harbor Laboratory","Annual Reviews","Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii"],"ids":[17,202,40,11,8,19,123,208,18,6139,39,230,32,344,101,6909,6941,9422],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/ex6KJoZujZOZFZh7jGfeHauiftuB3CI7iwJVFRDg_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/A7oGMwx1m3fFJlKJvQUVra8h0itmEa7JZW0q3Q0b_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp"],"datasets":[{"label":"","data":[26,15,12,9,6,5,4,2,2,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[27.96,16.13,12.9,9.68,6.45,5.38,4.3,2.15,2.15,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08,1.08],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0,0,0,0,0,0,0],"percentage":["0","0","0","0","0","0","0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[1,1,1,0,0,0,1,0,0],"percentage":["1.08","1.08","1.08","0","0","0","1.08","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,1,1,2,0,2,1,1,0],"percentage":["0","1.08","1.08","2.15","0","2.15","1.08","1.08","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[1,4,8,9,11,10,11,14,8],"percentage":["1.08","4.3","8.6","9.68","11.83","10.75","11.83","15.05","8.6"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,1,0,1,0,0,2,1,0],"percentage":["0","1.08","0","1.08","0","0","2.15","1.08","0"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0,0,0,0,1,0,0],"percentage":["0","0","0","0","0","0","1.08","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,1,1,0,1,0,1,0,1],"percentage":["0","1.08","1.08","0","1.08","0","1.08","0","1.08"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,1,4,4,2,4,2,2,1],"percentage":["0","1.08","4.3","4.3","2.15","4.3","2.15","2.15","1.08"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[1,3,4,7,7,8,9,12,5],"percentage":["1.08","3.23","4.3","7.53","7.53","8.6","9.68","12.9","5.38"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[1,2,1,1,1,0,2,2,1],"percentage":["1.08","2.15","1.08","1.08","1.08","0","2.15","2.15","1.08"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Abeydeera N. D. et al. Evoking picomolar binding in RNA by a single phosphorodithioate linkage // Nucleic Acids Research. 2016. Vol. 44. No. 17. pp. 8052-8064.
GOST all authors (up to 50)
Copy
Abeydeera N. D., Egli M., Cox N., Mercier K., Conde J. N., Pallan P. S., Mizurini D. M., Sierant M., Hibti F. E., Hassell T., Wang T., Liu F. W., Liu H., Martínez C., Sood A. K., Lybrand T. P., Frydman C., Monteiro R. Q., Gomer R., Nawrot B., Yang X. Evoking picomolar binding in RNA by a single phosphorodithioate linkage // Nucleic Acids Research. 2016. Vol. 44. No. 17. pp. 8052-8064.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1093/nar/gkw725
UR - https://doi.org/10.1093/nar/gkw725
TI - Evoking picomolar binding in RNA by a single phosphorodithioate linkage
T2 - Nucleic Acids Research
AU - Abeydeera, N Dinuka
AU - Egli, Martin
AU - Cox, Nehemiah
AU - Mercier, Karen
AU - Conde, Jonas N
AU - Pallan, Pradeep S.
AU - Mizurini, Daniella M.
AU - Sierant, Malgorzata
AU - Hibti, Fatima Ezzahra
AU - Hassell, Tom
AU - Wang, Tianzhi
AU - Liu, Feng Wu
AU - Liu, Hong-Min
AU - Martínez, Carlos
AU - Sood, Anil K.
AU - Lybrand, Terry P.
AU - Frydman, Chiraz
AU - Monteiro, Robson Q.
AU - Gomer, R.
AU - Nawrot, Barbara
AU - Yang, Xianbin
PY - 2016
DA - 2016/08/26 00:00:00
PB - Oxford University Press
SP - 8052-8064
IS - 17
VL - 44
SN - 0305-1048
SN - 1362-4962
ER -
Cite this
BibTex
Copy
@article{2016_Abeydeera,
author = {N Dinuka Abeydeera and Martin Egli and Nehemiah Cox and Karen Mercier and Jonas N Conde and Pradeep S. Pallan and Daniella M. Mizurini and Malgorzata Sierant and Fatima Ezzahra Hibti and Tom Hassell and Tianzhi Wang and Feng Wu Liu and Hong-Min Liu and Carlos Martínez and Anil K. Sood and Terry P. Lybrand and Chiraz Frydman and Robson Q. Monteiro and R. Gomer and Barbara Nawrot and Xianbin Yang},
title = {Evoking picomolar binding in RNA by a single phosphorodithioate linkage},
journal = {Nucleic Acids Research},
year = {2016},
volume = {44},
publisher = {Oxford University Press},
month = {aug},
url = {https://doi.org/10.1093/nar/gkw725},
number = {17},
pages = {8052--8064},
doi = {10.1093/nar/gkw725}
}
Cite this
MLA
Copy
Abeydeera, N. Dinuka, et al. “Evoking picomolar binding in RNA by a single phosphorodithioate linkage.” Nucleic Acids Research, vol. 44, no. 17, Aug. 2016, pp. 8052-8064. https://doi.org/10.1093/nar/gkw725.