Ovid Technologies (Wolters Kluwer Health)
Journal of Addiction Medicine
,  volume 19 ,  issue 2 ,  pages 195-201

Repetitive Transcranial Magnetic Stimulation for Alcohol Craving in Alcohol Use Disorders: A Meta-analysis

Michael Treiber
, 
Eva-Maria Tsapakis
, 
Konstantinos Fountoulakis
Publication type: Journal Article
Publication date: 2024-12-12
Ovid Technologies (Wolters Kluwer Health)
scimago Q1
wos Q1
SJR: 1.188
CiteScore: 5.4
Impact factor: 3.2
ISSN: 19320620, 19353227
Abstract
Aims

We aimed to evaluate the immediate and up to 3 months' effect of multiple-session repetitive transcranial magnetic stimulation (rTMS) on alcohol craving in AUD.

Methods

We performed a systematic review and random effects meta-analysis. We included randomized controlled trials with at least 10 sessions of rTMS and postintervention alcohol craving assessment. We evaluated the immediate and up to 3 months' effects of active rTMS versus sham stimulation.

Results

Twelve studies met inclusion criteria, including 475 participants across both treatment and control groups. rTMS reduced alcohol craving over sham stimulation immediately post-treatment (SMD = −0.79, 95% CI: −1.53 to −0.04, P = 0.04, I 2 = 93%). Concerning a maintenance effect, our meta-analysis revealed a medium effect for active rTMS in reduction of alcohol craving at 3-month follow-up (SMD = −0.44, 95% CI: −0.77 to 0.11, P < 0.01, I 2 = 38%). Our subgroup analysis revealed that rTMS targeting the medial prefrontal cortex (SMD = −2.12, 95% CI: −4.34 to 0.09, P = 0.06, I 2 = 94%) may be more effective than stimulating the right dorsolateral prefrontal cortex (SMD = −1.04, 95% CI: −2.56 to 0.48, P = 0.18, I 2 = 96%) or left dorsolateral prefrontal cortex (SMD = −0.27, 95% CI: −0.60 to 0.05, P = 0.10, I 2 = 0%) immediately after treatment.

Conclusion

A minimum of 10 sessions of rTMS reduced alcohol craving immediately after treatment; this effect seems to be sustained over a 3-month period. We provide limited evidence of superiority for rTMS targeting the medial prefrontal cortex.

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GOST Copy
Treiber M., Tsapakis E., Fountoulakis K. Repetitive Transcranial Magnetic Stimulation for Alcohol Craving in Alcohol Use Disorders: A Meta-analysis // Journal of Addiction Medicine. 2024. Vol. 19. No. 2. pp. 195-201.
GOST all authors (up to 50) Copy
Treiber M., Tsapakis E., Fountoulakis K. Repetitive Transcranial Magnetic Stimulation for Alcohol Craving in Alcohol Use Disorders: A Meta-analysis // Journal of Addiction Medicine. 2024. Vol. 19. No. 2. pp. 195-201.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1097/adm.0000000000001416
UR - https://journals.lww.com/10.1097/ADM.0000000000001416
TI - Repetitive Transcranial Magnetic Stimulation for Alcohol Craving in Alcohol Use Disorders: A Meta-analysis
T2 - Journal of Addiction Medicine
AU - Treiber, Michael
AU - Tsapakis, Eva-Maria
AU - Fountoulakis, Konstantinos
PY - 2024
DA - 2024/12/12
PB - Ovid Technologies (Wolters Kluwer Health)
SP - 195-201
IS - 2
VL - 19
PMID - 39665462
SN - 1932-0620
SN - 1935-3227
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Treiber,
author = {Michael Treiber and Eva-Maria Tsapakis and Konstantinos Fountoulakis},
title = {Repetitive Transcranial Magnetic Stimulation for Alcohol Craving in Alcohol Use Disorders: A Meta-analysis},
journal = {Journal of Addiction Medicine},
year = {2024},
volume = {19},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {dec},
url = {https://journals.lww.com/10.1097/ADM.0000000000001416},
number = {2},
pages = {195--201},
doi = {10.1097/adm.0000000000001416}
}
MLA
Cite this
MLA Copy
Treiber, Michael, et al. “Repetitive Transcranial Magnetic Stimulation for Alcohol Craving in Alcohol Use Disorders: A Meta-analysis.” Journal of Addiction Medicine, vol. 19, no. 2, Dec. 2024, pp. 195-201. https://journals.lww.com/10.1097/ADM.0000000000001416.