Ovid Technologies (Wolters Kluwer Health)

Annals of Surgery

, volume 281 , issue 5 , pages 872-883

Normothermic Liver Machine Perfusion At a Large European Center –Real World Outcomes Following 238 Applications

Felix Julius Krendl ^{1, 2}

B. Cardini ^{1, 2}

Margot Fodor ^{1, 2}

Jessica Singh ^{1, 2}

Florian Ponholzer ^{1, 2}

Franka Messner ^{1, 2}

A. Weissenbacher ^{1, 2}

Thomas Resch ^{1, 2}

M. Maglione ^{1, 2}

Christian Margreiter ^{1, 2}

Stephan Eschertzhuber ³

Christian Irsara ^{4, 5}

Andrea Griesmacher ^{4, 5}

Harald Schennach ^{6, 7}

Robert Breitkopf ⁸

Lisa Schlosser ⁹

Heinz Zoller ^{10, 11, 12}

Herbert Tilg ¹⁰

R. Oberhuber ^{1, 2}

Stefan Schneeberger ^{1, 2}

Hide authors affiliations Show authors affiliations: 12 affiliations

Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck |

Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria |

Department of Anesthesia and Intensive Care Medicine, Hospital Hall, Hall, Austria |

⁴

Central Institute for Medical and Chemical Laboratory Diagnostics, University Hospital of Innsbruck, 6020 Innsbruck, Austria |

⁵

Central Institute of Clinical Chemistry and Laboratory Medicine, Medical University of Innsbruck, Innsbruck, Austria |

⁶

Central Institute for Blood Transfusion and Immunological Department, University Hospital of Innsbruck, Innsbruck, Austria |

⁷

Central Institute for Blood Transfusion and Immunology, University Hospital of Innsbruck, Tirol Kliniken GmbH, Innsbruck, Austria |

⁸

Department of Anesthesia and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria |

⁹

Data Lab Hell GmbH, Zirl, Austria |

¹⁰

Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Innsbruck, Austria |

¹¹

Christian Doppler Laboratory for Iron and Phosphate Biology, Medical University of Innsbruck, 6020 Innsbruck, Austria |

¹²

Christian Doppler Laboratory for Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria |

Publication type: Journal Article

Publication date: 2025-01-20

Ovid Technologies (Wolters Kluwer Health)

Annals of Surgery

scimago Q1

wos Q1

SJR: 2.593

CiteScore: 14.4

Impact factor: 6.4

ISSN: 00034932, 15281140

DOI: 10.1097/sla.0000000000006634

Copy DOI

Abstract

Objective:

To report outcomes from routine clinical practice of liver transplantation (LT) following normothermic liver machine perfusion (NLMP) and compare to LT after static cold storage (SCS).

Background:

NLMP is emerging as a clinical routine in LT as has recently received renewed attention, however outcomes outside of clinical trials are lacking.

Methods:

All adult LT between February 2018 and January 2023 were included. Comprehensive viability assessment was applied during NLMP. Outcomes were compared between NLMP and SCS recipients, as well as benchmark and non-benchmark cases.

Results:

Of the 332 LT included, 174 underwent NLMP and 158 were transplanted following SCS. Sixty-seven organs were accepted and transplanted only under the premise of NLMP. One-year graft survival for SCS and NLMP recipients was 83.8% vs. 81.3% and 93.4% for benchmark cases in the overall cohort. Total preservation time had no influence on graft survival in the NLMP group but was associated with inferior 1-year graft survival in the SCS group. NLMP usage increased significantly over the duration of the study period, as did the median total preservation time. With increasing NLMP use and longer preservation times, nighttime surgery decreased significantly from 41.9% to 4.2%.

Conclusions:

Prolonged preservation times ease logistics and enable daytime surgery. The possibility of NLMP offers to expand liver transplantation without negatively affecting outcomes.

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GOST |

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Krendl F. J. et al. Normothermic Liver Machine Perfusion At a Large European Center –Real World Outcomes Following 238 Applications // Annals of Surgery. 2025. Vol. 281. No. 5. pp. 872-883.

GOST all authors (up to 50) Copy

Krendl F. J., Cardini B., Fodor M., Singh J., Ponholzer F., Messner F., Weissenbacher A., Resch T., Maglione M., Margreiter C., Eschertzhuber S., Irsara C., Griesmacher A., Schennach H., Breitkopf R., Schlosser L., Zoller H., Tilg H., Oberhuber R., Schneeberger S. Normothermic Liver Machine Perfusion At a Large European Center –Real World Outcomes Following 238 Applications // Annals of Surgery. 2025. Vol. 281. No. 5. pp. 872-883.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1097/sla.0000000000006634

UR - https://journals.lww.com/10.1097/SLA.0000000000006634

TI - Normothermic Liver Machine Perfusion At a Large European Center –Real World Outcomes Following 238 Applications

T2 - Annals of Surgery

AU - Krendl, Felix Julius

AU - Cardini, B.

AU - Fodor, Margot

AU - Singh, Jessica

AU - Ponholzer, Florian

AU - Messner, Franka

AU - Weissenbacher, A.

AU - Resch, Thomas

AU - Maglione, M.

AU - Margreiter, Christian

AU - Eschertzhuber, Stephan

AU - Irsara, Christian

AU - Griesmacher, Andrea

AU - Schennach, Harald

AU - Breitkopf, Robert

AU - Schlosser, Lisa

AU - Zoller, Heinz

AU - Tilg, Herbert

AU - Oberhuber, R.

AU - Schneeberger, Stefan

PY - 2025

DA - 2025/01/20

PB - Ovid Technologies (Wolters Kluwer Health)

SP - 872-883

IS - 5

VL - 281

SN - 0003-4932

SN - 1528-1140

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2025_Krendl,

author = {Felix Julius Krendl and B. Cardini and Margot Fodor and Jessica Singh and Florian Ponholzer and Franka Messner and A. Weissenbacher and Thomas Resch and M. Maglione and Christian Margreiter and Stephan Eschertzhuber and Christian Irsara and Andrea Griesmacher and Harald Schennach and Robert Breitkopf and Lisa Schlosser and Heinz Zoller and Herbert Tilg and R. Oberhuber and Stefan Schneeberger},

title = {Normothermic Liver Machine Perfusion At a Large European Center –Real World Outcomes Following 238 Applications},

journal = {Annals of Surgery},

year = {2025},

volume = {281},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

month = {jan},

url = {https://journals.lww.com/10.1097/SLA.0000000000006634},

number = {5},

pages = {872--883},

doi = {10.1097/sla.0000000000006634}

}

MLA

Cite this

MLA Copy

Krendl, Felix Julius, et al. “Normothermic Liver Machine Perfusion At a Large European Center –Real World Outcomes Following 238 Applications.” Annals of Surgery, vol. 281, no. 5, Jan. 2025, pp. 872-883. https://journals.lww.com/10.1097/SLA.0000000000006634.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Journal

Annals of Surgery

scimago Q1

wos Q1

SJR

2.593

CiteScore

14.4

Impact factor

6.4

ISSN

00034932 (Print)

15281140 (Electronic)