Ovid Technologies (Wolters Kluwer Health)
Alzheimer Disease and Associated Disorders
,  том 39 ,  издание 2 ,  страницы 140-149

Retinal and Vascular Findings in Optical Coherence Tomography in Healthy Cognitive Patients With Alzheimer Disease Biomarkers

Тип публикации: Journal Article
Дата публикации: 2025-04-01
Ovid Technologies (Wolters Kluwer Health)
SCImago Q2
WOS Q3
БС1
SJR: 0.485
CiteScore: 3
Impact factor: 1.4
ISSN: 08930341, 15464156
Краткое описание
Purpose:

This systematic review and meta-analysis aimed to explore differences in optical coherence tomography (OCT) findings between cognitively healthy individuals with Alzheimer disease (AD) biomarkers and healthy controls.

Methods:

A thorough literature review was conducted on February 6, 2023, in PubMed, Embase, Cochrane Library, LILACS, and DANS EASY Archive. Studies that involved cognitively healthy individuals with AD biomarkers undergoing OCT or OCT angiography were included. The risk of bias was assessed using validated tools. A narrative synthesis and meta-analysis were performed with standardized mean differences and I 2 heterogeneity assessments.

Results:

Seventeen studies comprising 601 participants with positive AD biomarkers and 881 controls were included. The reviewed studies varied in design, with notable findings indicating a reduction in retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness, alongside an increase in inner plexiform layer (IPL) thickness. In addition, OCT angiography revealed reduced vascular density and an enlarged foveal avascular zone—however, variations and inconsistencies in results led to inconclusive outcomes for RNFL and GCL-IPL meta-analyses.

Conclusion:

In summary, cognitively healthy individuals with positive AD biomarkers demonstrated RNFL, GCL thinning, and IPL thickening trends. Future longitudinal studies using standardized methods are critical to validate these OCT changes as potential early indicators for AD.

Для доступа к списку цитирований публикации необходимо авторизоваться.
 Войти с ORCID

Топ-30

Журналы

1
BMC Women's Health
BMC Women's Health, 1, 20%
BMC Women's Health
1 публикация, 20%
Critical Reviews in Clinical Laboratory Sciences
Critical Reviews in Clinical Laboratory Sciences, 1, 20%
Critical Reviews in Clinical Laboratory Sciences
1 публикация, 20%
Mammalian Genome
Mammalian Genome, 1, 20%
Mammalian Genome
1 публикация, 20%
Biomedical Optics Express
Biomedical Optics Express, 1, 20%
Biomedical Optics Express
1 публикация, 20%
Frontiers in Medicine
Frontiers in Medicine, 1, 20%
Frontiers in Medicine
1 публикация, 20%
1

Издатели

1
2
Springer Nature
Springer Nature, 2, 40%
Springer Nature
2 публикации, 40%
Taylor & Francis
Taylor & Francis, 1, 20%
Taylor & Francis
1 публикация, 20%
Optica Publishing Group
Optica Publishing Group, 1, 20%
Optica Publishing Group
1 публикация, 20%
Frontiers Media S.A.
Frontiers Media S.A., 1, 20%
Frontiers Media S.A.
1 публикация, 20%
1
2
  • Мы не учитываем публикации, у которых нет DOI.
  • Статистика публикаций обновляется еженедельно.

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
 Войти с ORCID
Метрики
5
Поделиться
Цитировать
ГОСТ |
Цитировать
ГОСТ Скопировать
Leal-Bernal C. et al. Retinal and Vascular Findings in Optical Coherence Tomography in Healthy Cognitive Patients With Alzheimer Disease Biomarkers // Alzheimer Disease and Associated Disorders. 2025. Vol. 39. No. 2. pp. 140-149.
ГОСТ со всеми авторами (до 50) Скопировать
Leal-Bernal C., Noriega- Ramírez S., Álvarez-Martínez J. V., Cifuentes-González C., Rojas-Carabali W., Manrique-Samer A., Flórez-Esparza V., Monsalve-García I., Amézquita-Villanueva J. S., Mejía-Salgado G., Nava-Mesa M. O., de-la-Torre A. Retinal and Vascular Findings in Optical Coherence Tomography in Healthy Cognitive Patients With Alzheimer Disease Biomarkers // Alzheimer Disease and Associated Disorders. 2025. Vol. 39. No. 2. pp. 140-149.
RIS |
Цитировать
RIS Скопировать
TY - JOUR
DO - 10.1097/wad.0000000000000669
UR - https://journals.lww.com/10.1097/WAD.0000000000000669
TI - Retinal and Vascular Findings in Optical Coherence Tomography in Healthy Cognitive Patients With Alzheimer Disease Biomarkers
T2 - Alzheimer Disease and Associated Disorders
AU - Leal-Bernal, Carlos
AU - Noriega- Ramírez, Santiago
AU - Álvarez-Martínez, José V.
AU - Cifuentes-González, Carlos
AU - Rojas-Carabali, William
AU - Manrique-Samer, Alejandro
AU - Flórez-Esparza, Valeria
AU - Monsalve-García, Isabella
AU - Amézquita-Villanueva, Juan S.
AU - Mejía-Salgado, Germán
AU - Nava-Mesa, Mauricio O.
AU - de-la-Torre, Alejandra
PY - 2025
DA - 2025/04/01
PB - Ovid Technologies (Wolters Kluwer Health)
SP - 140-149
IS - 2
VL - 39
SN - 0893-0341
SN - 1546-4156
ER -
BibTex |
Цитировать
BibTex (до 50 авторов) Скопировать
@article{2025_Leal-Bernal,
author = {Carlos Leal-Bernal and Santiago Noriega- Ramírez and José V. Álvarez-Martínez and Carlos Cifuentes-González and William Rojas-Carabali and Alejandro Manrique-Samer and Valeria Flórez-Esparza and Isabella Monsalve-García and Juan S. Amézquita-Villanueva and Germán Mejía-Salgado and Mauricio O. Nava-Mesa and Alejandra de-la-Torre},
title = {Retinal and Vascular Findings in Optical Coherence Tomography in Healthy Cognitive Patients With Alzheimer Disease Biomarkers},
journal = {Alzheimer Disease and Associated Disorders},
year = {2025},
volume = {39},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {apr},
url = {https://journals.lww.com/10.1097/WAD.0000000000000669},
number = {2},
pages = {140--149},
doi = {10.1097/wad.0000000000000669}
}
MLA
Цитировать
MLA Скопировать
Leal-Bernal, Carlos, et al. “Retinal and Vascular Findings in Optical Coherence Tomography in Healthy Cognitive Patients With Alzheimer Disease Biomarkers.” Alzheimer Disease and Associated Disorders, vol. 39, no. 2, Apr. 2025, pp. 140-149. https://journals.lww.com/10.1097/WAD.0000000000000669.
Ошибка в публикации?