Shock, volume 50, issue 3, pages 273-279
Involvement of Aromatic Metabolites in the Pathogenesis of Septic Shock
Publication type: Journal Article
Publication date: 2017-11-21
Critical Care and Intensive Care Medicine
Emergency Medicine
Abstract
We hypothesized that aromatic microbial metabolites (AMM), such as phenyllactic (PhLA), p-hydroxyphenylacetic (p-HPhAA), and p-hydroxyphenyllactic (p-HPhLA) acids, contribute to the pathogenesis of septic shock.Clinical and laboratory data of patients with community-acquired pneumonia were obtained on intensive care unit admission and the next day. Patients were divided into two groups based on septic shock presence or absence. The levels of AMM (PhLA, p-HPhAA, p-HPhLA, and their sum, ∑3AMM), catecholamine metabolites (3,4-dihydroxymandelic [DHMA], 3,4-dihydroxyphenylacetic [DOPAC], and homovanillic [HVA] acids), lactate, N-terminal pro-brain natriuretic peptide (NT-proBNP), inducible nitric oxide synthase (iNOS), and procalcitonin (PCT) were compared. Correlations between AMM and clinical and laboratory data were calculated.There were 20 patients in the septic shock group and 21 in the nonseptic shock group. On admission, the septic shock patients demonstrated significantly higher levels of PhLA (2.3 vs. 0.8 μmol/L), p-HPhAA (4.6 vs. 1.4 μmol/L), p-HPhLA (7.4 vs. 2.6 μmol/L), HVA, lactate, and significantly lower levels of iNOS. The next day, the two groups also showed significant differences in the levels of PCT and NT-proBNP. The correlation between ∑3AMM and presence of shock, levels of lactate, HVA, and NT-proBNP on admission was 0.44, 0.67, 0.57, and 0.38, respectively, and the correlation on the next day was 0.59, 0.73, 0.76, and 0.6, respectively (P < 0.01). These findings can be explained by the ability of AMM to reduce tyrosine hydroxylase activity, thus limiting the synthesis of catecholamines.AMM are involved in the pathogenesis of septic shock.
Top-30
Citations by journals
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1 publication, 3.33%
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1 publication, 3.33%
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1 publication, 3.33%
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1 publication, 3.33%
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1 publication, 3.33%
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Russian Chemical Reviews
1 publication, 3.33%
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
10 publications, 33.33%
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Elsevier
3 publications, 10%
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Wiley
3 publications, 10%
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Springer Nature
2 publications, 6.67%
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V. A. Negovsky Research Institute of General Reanimatology
2 publications, 6.67%
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Wolters Kluwer Health
1 publication, 3.33%
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American Association for the Advancement of Science (AAAS)
1 publication, 3.33%
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Eco-Vector LLC
1 publication, 3.33%
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Media Sphere Publishing Group
1 publication, 3.33%
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Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
1 publication, 3.33%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 3.33%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Beloborodova N. V. et al. Involvement of Aromatic Metabolites in the Pathogenesis of Septic Shock // Shock. 2017. Vol. 50. No. 3. pp. 273-279.
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Beloborodova N. V., Sarshor Y. N., Bedova A. Y., Chernevskaya E. A., Pautova A. K. Involvement of Aromatic Metabolites in the Pathogenesis of Septic Shock // Shock. 2017. Vol. 50. No. 3. pp. 273-279.
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TY - JOUR
DO - 10.1097/SHK.0000000000001064
UR - https://doi.org/10.1097/SHK.0000000000001064
TI - Involvement of Aromatic Metabolites in the Pathogenesis of Septic Shock
T2 - Shock
AU - Beloborodova, Natalia V.
AU - Sarshor, Yulia N.
AU - Bedova, Aleksandra Yu.
AU - Chernevskaya, Ekaterina A.
AU - Pautova, Alisa K.
PY - 2017
DA - 2017/11/21 00:00:00
PB - Wolters Kluwer Health
SP - 273-279
IS - 3
VL - 50
SN - 1073-2322
SN - 1540-0514
ER -
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@article{2017_Beloborodova,
author = {Natalia V. Beloborodova and Yulia N. Sarshor and Aleksandra Yu. Bedova and Ekaterina A. Chernevskaya and Alisa K. Pautova},
title = {Involvement of Aromatic Metabolites in the Pathogenesis of Septic Shock},
journal = {Shock},
year = {2017},
volume = {50},
publisher = {Wolters Kluwer Health},
month = {nov},
url = {https://doi.org/10.1097/SHK.0000000000001064},
number = {3},
pages = {273--279},
doi = {10.1097/SHK.0000000000001064}
}
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MLA
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Beloborodova, Natalia V., et al. “Involvement of Aromatic Metabolites in the Pathogenesis of Septic Shock.” Shock, vol. 50, no. 3, Nov. 2017, pp. 273-279. https://doi.org/10.1097/SHK.0000000000001064.