Journal of General Virology, volume 102, issue 9
Effect of immature tick-borne encephalitis virus particles on antiviral activity of 5-aminoisoxazole-3-carboxylic acid adamantylmethyl esters
Fomina Anastasiia D.
1, 2
,
Nikitin N.
3
,
Illarionova Viktoria V.
1, 3
,
Volok Viktor P.
1, 3
,
Kozlovskaya Liubov I.
1, 4
,
Rogova Anastasia A.
1
,
Averina Elena B.
2
,
Osolodkin Dmitry I.
1, 2, 4
,
Karganova Galina G.
1, 4
Publication type: Journal Article
Publication date: 2021-09-21
Journal:
Journal of General Virology
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.8
ISSN: 00221317, 14652099
Virology
Abstract
Tick-borne encephalitis virus (TBEV), a member of the genusFlavivirus, is common in Europe and Asia and causes a severe disease of the central nervous system. A promising approach in the development of therapy for TBEV infection is the search for small molecule antivirals targeting the flavivirus envelope protein E, particularly its β-n-octyl-d-glucoside binding pocket (β-OG pocket). However, experimental studies of candidate antivirals may be complicated by varying amounts and different forms of the protein E in the virus samples. Viral particles with different conformations and arrangements of the protein E are produced during the replication cycle of flaviviruses, including mature, partially mature, and immature forms, as well as subviral particles lacking genomic RNA. The immature forms are known to be abundant in the viral population. We obtained immature virion preparations of TBEV, characterized them by RT-qPCR, and assessedin vivoandin vitroinfectivity of the residual mature virions in the immature virus samples. Analysis of the β-OG pocket structure on the immature virions confirmed the possibility of binding of adamantylmethyl esters of 5-aminoisoxazole-3-carboxylic acid in the pocket. We demonstrated that the antiviral activity of these compounds in plaque reduction assay is significantly reduced in the presence of immature TBEV particles.
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Antiviral Research
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1 publication, 33.33%
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Archives of Virology
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1 publication, 33.33%
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Emerging Microbes and Infections
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Citations by publishers
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1
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Springer Nature
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Springer Nature
2 publications, 66.67%
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Elsevier
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Elsevier
1 publication, 33.33%
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1
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Tuchynskaya K. K. et al. Effect of immature tick-borne encephalitis virus particles on antiviral activity of 5-aminoisoxazole-3-carboxylic acid adamantylmethyl esters // Journal of General Virology. 2021. Vol. 102. No. 9.
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Tuchynskaya K. K., Fomina A. D., Nikitin N., Illarionova V. V., Volok V. P., Kozlovskaya L. I., Rogova A. A., Vasilenko D. A., Averina E. B., Osolodkin D. I., Karganova G. G. Effect of immature tick-borne encephalitis virus particles on antiviral activity of 5-aminoisoxazole-3-carboxylic acid adamantylmethyl esters // Journal of General Virology. 2021. Vol. 102. No. 9.
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TY - JOUR
DO - 10.1099/JGV.0.001658
UR - https://doi.org/10.1099%2FJGV.0.001658
TI - Effect of immature tick-borne encephalitis virus particles on antiviral activity of 5-aminoisoxazole-3-carboxylic acid adamantylmethyl esters
T2 - Journal of General Virology
AU - Tuchynskaya, Ksenia K.
AU - Fomina, Anastasiia D.
AU - Nikitin, N.
AU - Illarionova, Viktoria V.
AU - Volok, Viktor P.
AU - Kozlovskaya, Liubov I.
AU - Rogova, Anastasia A.
AU - Vasilenko, Dmitry A.
AU - Averina, Elena B.
AU - Osolodkin, Dmitry I.
AU - Karganova, Galina G.
PY - 2021
DA - 2021/09/21 00:00:00
PB - Microbiology Society
IS - 9
VL - 102
SN - 0022-1317
SN - 1465-2099
ER -
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@article{2021_Tuchynskaya,
author = {Ksenia K. Tuchynskaya and Anastasiia D. Fomina and N. Nikitin and Viktoria V. Illarionova and Viktor P. Volok and Liubov I. Kozlovskaya and Anastasia A. Rogova and Dmitry A. Vasilenko and Elena B. Averina and Dmitry I. Osolodkin and Galina G. Karganova},
title = {Effect of immature tick-borne encephalitis virus particles on antiviral activity of 5-aminoisoxazole-3-carboxylic acid adamantylmethyl esters},
journal = {Journal of General Virology},
year = {2021},
volume = {102},
publisher = {Microbiology Society},
month = {sep},
url = {https://doi.org/10.1099%2FJGV.0.001658},
number = {9},
doi = {10.1099/JGV.0.001658}
}