Open Access
Genome Research, volume 30, issue 5, pages 776-789
Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains
Khrameeva Ekaterina
,
Kurochkin Ilia
,
Kurochkin Ilia
1
,
Han Dingding
2
,
Guijarro Patricia
3
,
Kanton Sabina
4
,
Santel Malgorzata
4
,
Qian Zhengzong
3
,
Shen Rong
3
,
Mazin Pavel
5, 6
,
Mazin Pavel
,
Sabirov Marat
,
Sabirov Marat
7
,
Bulat Matvei
1
,
Efimova Olga
1
,
Tkachev Anna
5, 6
,
Guo Song
,
Guo Song
6, 8
,
Sherwood Chet C.
,
Sherwood Chet C.
9
,
Camp J. Gray
,
Camp J Gray
10
,
Pääbo Svante
,
Паабо С.
4
,
Treutlein Barbara
,
Treutlein Barbara
11
,
Khaitovich Philipp
,
3
CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai, 200031, China.
|
4
Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
|
8
3CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai, 200031, China
|
10
Institute of Molecular and Clinical Ophthalmology, Basel, 4057, Switzerland.
|
Publication type: Journal Article
Publication date: 2020-05-18
Journal:
Genome Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7
ISSN: 10889051, 15495469
PubMed ID:
32424074
Genetics
Genetics (clinical)
Abstract
Identification of gene expression traits unique to the human brain sheds light on the mechanisms of human cognition. Here we searched for gene expression traits separating humans from other primates by analyzing 88,047 cell nuclei and 422 tissue samples representing 33 brain regions of humans, chimpanzees, bonobos, and macaques. We show that gene expression evolves rapidly within cell types, with more than two-thirds of cell type-specific differences not detected using conventional RNA sequencing of tissue samples. Neurons tend to evolve faster in all hominids, but non-neuronal cell types, such as astrocytes and oligodendrocyte progenitors, show more differences on the human lineage, including alterations of spatial distribution across neocortical layers.
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15
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3 publications, 3.26%
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Wiley
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Editions E D K
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Editions E D K, 1, 1.09%
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1 publication, 1.09%
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1 publication, 1.09%
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Human Springer Nature Review, 1, 1.09%
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1 publication, 1.09%
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1 publication, 1.09%
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1 publication, 1.09%
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5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Khrameeva E. et al. Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains // Genome Research. 2020. Vol. 30. No. 5. pp. 776-789.
GOST all authors (up to 50)
Copy
Khrameeva E., Khrameeva E., Kurochkin I., Kurochkin I., Han D., Guijarro P., Kanton S., Santel M., Qian Z., Shen R., Mazin P., Mazin P., Sabirov M., Sabirov M., Bulat M., Efimova O., Tkachev A., Guo S., Guo S., Sherwood C. C., Sherwood C. C., Camp J. G., Camp J. G., Pääbo S., Паабо С., Treutlein B., Treutlein B., Khaitovich P., Khaitovich P. Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains // Genome Research. 2020. Vol. 30. No. 5. pp. 776-789.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1101/gr.256958.119
UR - https://doi.org/10.1101%2Fgr.256958.119
TI - Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains
T2 - Genome Research
AU - Khrameeva, Ekaterina
AU - Kurochkin, Ilia
AU - Han, Dingding
AU - Guijarro, Patricia
AU - Kanton, Sabina
AU - Santel, Malgorzata
AU - Qian, Zhengzong
AU - Shen, Rong
AU - Mazin, Pavel
AU - Sabirov, Marat
AU - Bulat, Matvei
AU - Efimova, Olga
AU - Tkachev, Anna
AU - Guo, Song
AU - Sherwood, Chet C.
AU - Camp, J. Gray
AU - Pääbo, Svante
AU - Treutlein, Barbara
AU - Khaitovich, Philipp
AU - Khrameeva, Ekaterina E.
AU - Kurochkin, Ilia
AU - Mazin, Pavel
AU - Sabirov, Marat
AU - Guo, Song
AU - Sherwood, Chet C.
AU - Camp, J Gray
AU - Паабо, С.
AU - Treutlein, Barbara
AU - Khaitovich, Philipp
PY - 2020
DA - 2020/05/18 00:00:00
PB - Cold Spring Harbor Laboratory
SP - 776-789
IS - 5
VL - 30
PMID - 32424074
SN - 1088-9051
SN - 1549-5469
ER -
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BibTex
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@article{2020_Khrameeva,
author = {Ekaterina Khrameeva and Ilia Kurochkin and Dingding Han and Patricia Guijarro and Sabina Kanton and Malgorzata Santel and Zhengzong Qian and Rong Shen and Pavel Mazin and Marat Sabirov and Matvei Bulat and Olga Efimova and Anna Tkachev and Song Guo and Chet C. Sherwood and J. Gray Camp and Svante Pääbo and Barbara Treutlein and Philipp Khaitovich and Ekaterina E. Khrameeva and Ilia Kurochkin and Pavel Mazin and Marat Sabirov and Song Guo and Chet C. Sherwood and J Gray Camp and С. Паабо and Barbara Treutlein and Philipp Khaitovich},
title = {Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains},
journal = {Genome Research},
year = {2020},
volume = {30},
publisher = {Cold Spring Harbor Laboratory},
month = {may},
url = {https://doi.org/10.1101%2Fgr.256958.119},
number = {5},
pages = {776--789},
doi = {10.1101/gr.256958.119}
}
Cite this
MLA
Copy
Khrameeva, Ekaterina, et al. “Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains.” Genome Research, vol. 30, no. 5, May. 2020, pp. 776-789. https://doi.org/10.1101%2Fgr.256958.119.
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