Open Access
Cold Spring Harbor perspectives in medicine, volume 6, issue 10, pages a025395
Resistance to Macrolide Antibiotics in Public Health Pathogens
1
Tetraphase Pharmaceuticals, Watertown, Massachusetts 02472.
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Publication type: Journal Article
Publication date: 2016-08-15
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.4
ISSN: 21571422
PubMed ID:
27527699
General Biochemistry, Genetics and Molecular Biology
Abstract
Macrolide resistance mechanisms can be target-based with a change in a 23S ribosomal RNA (rRNA) residue or a mutation in ribosomal protein L4 or L22 affecting the ribosome's interaction with the antibiotic. Alternatively, mono- or dimethylation of A2058 in domain V of the 23S rRNA by an acquired rRNA methyltransferase, the product of an erm (erythromycin ribosome methylation) gene, can interfere with antibiotic binding. Acquired genes encoding efflux pumps, most predominantly mef(A) + msr(D) in pneumococci/streptococci and msr(A/B) in staphylococci, also mediate resistance. Drug-inactivating mechanisms include phosphorylation of the 2'-hydroxyl of the amino sugar found at position C5 by phosphotransferases and hydrolysis of the macrocyclic lactone by esterases. These acquired genes are regulated by either translation or transcription attenuation, largely because cells are less fit when these genes, especially the rRNA methyltransferases, are highly induced or constitutively expressed. The induction of gene expression is cleverly tied to the mechanism of action of macrolides, relying on antibiotic-bound ribosomes stalled at specific sequences of nascent polypeptides to promote transcription or translation of downstream sequences.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Cite this
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RIS |
BibTex |
MLA
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GOST
Copy
Fyfe C. et al. Resistance to Macrolide Antibiotics in Public Health Pathogens // Cold Spring Harbor perspectives in medicine. 2016. Vol. 6. No. 10. p. a025395.
GOST all authors (up to 50)
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Fyfe C., Grossman T. H., Kerstein K., Sutcliffe J. Resistance to Macrolide Antibiotics in Public Health Pathogens // Cold Spring Harbor perspectives in medicine. 2016. Vol. 6. No. 10. p. a025395.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1101/cshperspect.a025395
UR - https://doi.org/10.1101%2Fcshperspect.a025395
TI - Resistance to Macrolide Antibiotics in Public Health Pathogens
T2 - Cold Spring Harbor perspectives in medicine
AU - Fyfe, Corey
AU - Grossman, Trudy H
AU - Kerstein, Kathy
AU - Sutcliffe, Joyce
PY - 2016
DA - 2016/08/15 00:00:00
PB - Cold Spring Harbor Laboratory
SP - a025395
IS - 10
VL - 6
PMID - 27527699
SN - 2157-1422
ER -
Cite this
BibTex
Copy
@article{2016_Fyfe,
author = {Corey Fyfe and Trudy H Grossman and Kathy Kerstein and Joyce Sutcliffe},
title = {Resistance to Macrolide Antibiotics in Public Health Pathogens},
journal = {Cold Spring Harbor perspectives in medicine},
year = {2016},
volume = {6},
publisher = {Cold Spring Harbor Laboratory},
month = {aug},
url = {https://doi.org/10.1101%2Fcshperspect.a025395},
number = {10},
pages = {a025395},
doi = {10.1101/cshperspect.a025395}
}
Cite this
MLA
Copy
Fyfe, Corey, et al. “Resistance to Macrolide Antibiotics in Public Health Pathogens.” Cold Spring Harbor perspectives in medicine, vol. 6, no. 10, Aug. 2016, p. a025395. https://doi.org/10.1101%2Fcshperspect.a025395.