Genes and Development

, том 37 , издание 11-12 , страницы 474-489

Translational regulation by uORFs and start codon selection stringency

Тип публикации: Journal Article

Дата публикации: 2023-06-01

Cold Spring Harbor Laboratory

Genes and Development

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wos Q1

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SJR: 4.005

CiteScore: 13

Impact factor: 7.7

ISSN: 08909369, 15495477

DOI: 10.1101/gad.350752.123

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PubMed ID: 37433636

Genetics

Developmental Biology

Краткое описание

In addition to the main, protein-coding, open reading frame (mORF), many eukaryotic mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing 5′ of the mORF start site. Whereas translation of uORFs generally represses translation of the mORFs, a subset of uORFs serves as a nexus for regulating translation of the mORF. In this review, we summarize the mechanisms by which uORFs can repress or stimulate mRNA translation, highlight uORF-mediated translational repression involving ribosome queuing, and critically evaluate recently described alternatives to the delayed reinitiation model for uORF-mediated regulation of theGCN4/ATF4mRNAs.

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Dever T. E. et al. Translational regulation by uORFs and start codon selection stringency // Genes and Development. 2023. Vol. 37. No. 11-12. pp. 474-489.

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Dever T. E., Ivanov I. P., Hinnebusch A. G. Translational regulation by uORFs and start codon selection stringency // Genes and Development. 2023. Vol. 37. No. 11-12. pp. 474-489.

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TY - JOUR

DO - 10.1101/gad.350752.123

UR - http://genesdev.cshlp.org/lookup/doi/10.1101/gad.350752.123

TI - Translational regulation by uORFs and start codon selection stringency

T2 - Genes and Development

AU - Dever, T. E.

AU - Ivanov, Ivaylo P

AU - Hinnebusch, Alan G.

PY - 2023

DA - 2023/06/01

PB - Cold Spring Harbor Laboratory

SP - 474-489

IS - 11-12

VL - 37

PMID - 37433636

SN - 0890-9369

SN - 1549-5477

ER -

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@article{2023_Dever,

author = {T. E. Dever and Ivaylo P Ivanov and Alan G. Hinnebusch},

title = {Translational regulation by uORFs and start codon selection stringency},

journal = {Genes and Development},

year = {2023},

volume = {37},

publisher = {Cold Spring Harbor Laboratory},

month = {jun},

url = {http://genesdev.cshlp.org/lookup/doi/10.1101/gad.350752.123},

number = {11-12},

pages = {474--489},

doi = {10.1101/gad.350752.123}

}

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Dever, T. E., et al. “Translational regulation by uORFs and start codon selection stringency.” Genes and Development, vol. 37, no. 11-12, Jun. 2023, pp. 474-489. http://genesdev.cshlp.org/lookup/doi/10.1101/gad.350752.123.