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PRX Quantum

, volume 2 , issue 1 , publication number 010305

Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange

Nithya Arunkumar ^{1, 2, 3}

Dominik B Bucher ^{1, 3, 4}

Dominik Bucher ^{1, 3, 4}

Matthew J. Turner ^{1, 5}

Matthew Turner ^{1, 5}

Patrick Tomhon ⁶

David Glenn ¹

Sören Lehmkuhl ⁶

MIKHAIL D. LUKIN ¹

Hongkun Park ^{1, 7}

Matthew A. Rosen ^{1, 8, 9}

Thomas Theis ^{6, 10, 11}

RONALD L. WALSWORTH ^{1, 2, 3, 5, 12, 13}

R. L. Walsworth ^{1, 2, 3, 5, 12, 13}

Hide authors affiliations Show authors affiliations: 13 affiliations

Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA |

Quantum Technology Center, University of Maryland, College Park, Maryland 20742, USA |

Harvard-Smithsonian Center for Astrophysics, Cambridge, Massachusetts 02138, USA |

⁴

Department of chemistry, Technical University of Munich, Munich, Germany |

⁵

Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA |

⁶

Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA |

⁷

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA |

⁸

A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts 02129, USA |

⁹

Harvard Medical School, Boston, Massachusetts 02129, USA |

¹⁰

Department of Physics, North Carolina State University, Raleigh, North Carolina 27695, USA |

¹¹

UNC & NC State Joint Department of Biomedical Engineering, Raleigh, North Carolina 27695, USA |

¹²

Department of Physics, University of Maryland, College Park, Maryland 20742, USA |

¹³

Department of Electrical and Computer Engineering, University of Maryland, College Park, Maryland 20742, USA |

Publication type: Journal Article

Publication date: 2021-01-11

American Physical Society (APS)

PRX Quantum

scimago Q1

wos Q1

SJR: 5.341

CiteScore: 20.0

Impact factor: 11.0

ISSN: 26913399

DOI: 10.1103/prxquantum.2.010305

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General Medicine

Abstract

Optically-probed nitrogen-vacancy (NV) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 picoliters. However, a key challenge for NV-NMR is detecting samples at millimolar concentrations. Here, we demonstrate an improvement in NV-NMR proton concentration sensitivity of about $10^5$ over thermal polarization by hyperpolarizing sample proton spins through signal amplification by reversible exchange (SABRE), enabling micron-scale NMR of small molecule sample concentrations as low as 1 millimolar in picoliter volumes. The SABRE-enhanced NV-NMR technique may enable detection and chemical analysis of low concentration molecules and their dynamics in complex micron-scale systems such as single-cells.

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Arunkumar N. et al. Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange // PRX Quantum. 2021. Vol. 2. No. 1. 010305

GOST all authors (up to 50) Copy

Arunkumar N., Bucher D. B., Bucher D., Turner M. J., Turner M., Tomhon P., Glenn D., Lehmkuhl S., LUKIN M. D., Park H., Rosen M. A., Theis T., WALSWORTH R. L., Walsworth R. L. Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange // PRX Quantum. 2021. Vol. 2. No. 1. 010305

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RIS Copy

TY - JOUR

DO - 10.1103/prxquantum.2.010305

UR - https://doi.org/10.1103/prxquantum.2.010305

TI - Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange

T2 - PRX Quantum

AU - Arunkumar, Nithya

AU - Bucher, Dominik B

AU - Bucher, Dominik

AU - Turner, Matthew J.

AU - Turner, Matthew

AU - Tomhon, Patrick

AU - Glenn, David

AU - Lehmkuhl, Sören

AU - LUKIN, MIKHAIL D.

AU - Park, Hongkun

AU - Rosen, Matthew A.

AU - Theis, Thomas

AU - WALSWORTH, RONALD L.

AU - Walsworth, R. L.

PY - 2021

DA - 2021/01/11

PB - American Physical Society (APS)

IS - 1

VL - 2

SN - 2691-3399

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Arunkumar,

author = {Nithya Arunkumar and Dominik B Bucher and Dominik Bucher and Matthew J. Turner and Matthew Turner and Patrick Tomhon and David Glenn and Sören Lehmkuhl and MIKHAIL D. LUKIN and Hongkun Park and Matthew A. Rosen and Thomas Theis and RONALD L. WALSWORTH and R. L. Walsworth},

title = {Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange},

journal = {PRX Quantum},

year = {2021},

volume = {2},

publisher = {American Physical Society (APS)},

month = {jan},

url = {https://doi.org/10.1103/prxquantum.2.010305},

number = {1},

pages = {010305},

doi = {10.1103/prxquantum.2.010305}

}

Publisher

American Physical Society (APS)

Journal

PRX Quantum

scimago Q1

wos Q1

SJR

5.341

CiteScore

20.0

Impact factor

11.0

ISSN

26913399 (Electronic)

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