Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials, volume 75, issue 2, pages 175-182
Taxifolin tubes: crystal engineering and characteristics.
Terekhov Roman
1
,
Tyukavkina Nonna A.
1
,
Shylov Genadiy V.
2
,
Utenishev Andrey N.
1, 2
,
Porozov Yuri B.
3, 4
Publication type: Journal Article
Publication date: 2019-03-16
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 1.9
ISSN: 20525192, 20525206
Materials Chemistry
Metals and Alloys
Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Abstract
Taxifolin, also known as dihydroquercetin, is the major flavonoid in larch wood. It is well known as an antioxidant and a bioactive substance. Taxifolin as an active pharmaceutical ingredient is produced industrially in crystalline form during the processing of larch wood. Some information is available on nano- and microstructured particles of taxifolin. This paper reports on the generation of a new form of taxifolin as microtubes. These self-assembled tubes were obtained from raw taxifolin by crystal engineering with urea at ambient temperature and pressure. The parameters of temperature, pH value, molar ratio of taxifolin and urea, and time duration were optimized for yield enhancement of the microtubes. The water solubility and melting point of the new form of taxifolin were established. The microtubes were characterized by X-ray diffraction, X-ray powder diffraction, microscopy, mass spectrometry, 1H NMR spectroscopy, UV spectroscopy and Fourier transform infrared spectroscopy methods. The experimental results demonstrate that the microtubes and raw taxifolin both exist in crystalline form with the same structure of the crystal unit. However, they are characterized by different morphological and physicochemical properties. Computer simulation was performed to explain the mechanism of the self-assembly process.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Terekhov R. et al. Taxifolin tubes: crystal engineering and characteristics. // Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials. 2019. Vol. 75. No. 2. pp. 175-182.
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Terekhov R., Selivanova I. A., Tyukavkina N. A., Shylov G. V., Utenishev A. N., Porozov Y. B. Taxifolin tubes: crystal engineering and characteristics. // Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials. 2019. Vol. 75. No. 2. pp. 175-182.
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TY - JOUR
DO - 10.1107/S2052520619000969
UR - https://doi.org/10.1107%2FS2052520619000969
TI - Taxifolin tubes: crystal engineering and characteristics.
T2 - Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials
AU - Terekhov, Roman
AU - Selivanova, Irina A.
AU - Tyukavkina, Nonna A.
AU - Shylov, Genadiy V.
AU - Utenishev, Andrey N.
AU - Porozov, Yuri B.
PY - 2019
DA - 2019/03/16 00:00:00
PB - International Union of Crystallography (IUCr)
SP - 175-182
IS - 2
VL - 75
SN - 2052-5192
SN - 2052-5206
ER -
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@article{2019_Terekhov,
author = {Roman Terekhov and Irina A. Selivanova and Nonna A. Tyukavkina and Genadiy V. Shylov and Andrey N. Utenishev and Yuri B. Porozov},
title = {Taxifolin tubes: crystal engineering and characteristics.},
journal = {Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials},
year = {2019},
volume = {75},
publisher = {International Union of Crystallography (IUCr)},
month = {mar},
url = {https://doi.org/10.1107%2FS2052520619000969},
number = {2},
pages = {175--182},
doi = {10.1107/S2052520619000969}
}
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Terekhov, Roman, et al. “Taxifolin tubes: crystal engineering and characteristics..” Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials, vol. 75, no. 2, Mar. 2019, pp. 175-182. https://doi.org/10.1107%2FS2052520619000969.