Open Access
,
volume 31
,
issue 4: Adv. in Neurophoton. for Non
,
pages 1-13
Comprehensive Optimization of Interferometric Diffusing Wave Spectroscopy (iDWS)
Publication type: Journal Article
Publication date: 2025-07-01
scimago Q1
wos Q1
SJR: 1.012
CiteScore: 9.9
Impact factor: 5.1
ISSN: 1077260X, 15584542
Abstract
Light speckle fluctuations provide a means for noninvasive measurements of cerebral blood flow index (CBFi). While conventional Diffuse Correlation Spectroscopy (DCS) quantifies these fluctuations to provide marginal brain sensitivity for CBFi in adult humans, new techniques have emerged to improve diffuse light throughput and brain sensitivity. Here we further optimize one such approach, interferometric diffusing wave spectroscopy (iDWS), with respect to the number of independent channels, camera duty cycle and full well capacity, incident laser power, noise and artifact mitigation, and data processing. We build the system on a cart and define conditions for stable operation. We show pulsatile CBFi monitoring at 4–4.5 cm source-collector separation in adults with moderate pigmentation (Fitzpatrick 4). We also report preliminary clinical measurements of patient CBFi in the Neuro Intensive Care Unit (Neuro ICU). These results push the boundaries of iDWS CBFi monitoring performance beyond previous reports.
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Zhao M. et al. Comprehensive Optimization of Interferometric Diffusing Wave Spectroscopy (iDWS) // IEEE Journal of Selected Topics in Quantum Electronics. 2025. Vol. 31. No. 4: Adv. in Neurophoton. for Non. pp. 1-13.
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Zhao M., DICKSTEIN L., Nadig A. S., Zhou W., Aparanji S., Estrada H. G., García-Estrada H., Liu S., Zhou T., Weijian Yang W. Y., Lord A., Srinivasan V. J. Comprehensive Optimization of Interferometric Diffusing Wave Spectroscopy (iDWS) // IEEE Journal of Selected Topics in Quantum Electronics. 2025. Vol. 31. No. 4: Adv. in Neurophoton. for Non. pp. 1-13.
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TY - JOUR
DO - 10.1109/jstqe.2025.3537642
UR - https://ieeexplore.ieee.org/document/10886941/
TI - Comprehensive Optimization of Interferometric Diffusing Wave Spectroscopy (iDWS)
T2 - IEEE Journal of Selected Topics in Quantum Electronics
AU - Zhao, Mingjun
AU - DICKSTEIN, LEAH
AU - Nadig, Akshay S.
AU - Zhou, Wenjun
AU - Aparanji, Santosh
AU - Estrada, Hector Garcia
AU - García-Estrada, H.
AU - Liu, Shing-Jiuan
AU - Zhou, Ting
AU - Weijian Yang, Weijian Yang
AU - Lord, Aaron
AU - Srinivasan, Vivek J
PY - 2025
DA - 2025/07/01
PB - Institute of Electrical and Electronics Engineers (IEEE)
SP - 1-13
IS - 4: Adv. in Neurophoton. for Non
VL - 31
SN - 1077-260X
SN - 1558-4542
ER -
Cite this
BibTex (up to 50 authors)
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@article{2025_Zhao,
author = {Mingjun Zhao and LEAH DICKSTEIN and Akshay S. Nadig and Wenjun Zhou and Santosh Aparanji and Hector Garcia Estrada and H. García-Estrada and Shing-Jiuan Liu and Ting Zhou and Weijian Yang Weijian Yang and Aaron Lord and Vivek J Srinivasan},
title = {Comprehensive Optimization of Interferometric Diffusing Wave Spectroscopy (iDWS)},
journal = {IEEE Journal of Selected Topics in Quantum Electronics},
year = {2025},
volume = {31},
publisher = {Institute of Electrical and Electronics Engineers (IEEE)},
month = {jul},
url = {https://ieeexplore.ieee.org/document/10886941/},
number = {4: Adv. in Neurophoton. for Non},
pages = {1--13},
doi = {10.1109/jstqe.2025.3537642}
}
Cite this
MLA
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Zhao, Mingjun, et al. “Comprehensive Optimization of Interferometric Diffusing Wave Spectroscopy (iDWS).” IEEE Journal of Selected Topics in Quantum Electronics, vol. 31, no. 4: Adv. in Neurophoton. for Non, Jul. 2025, pp. 1-13. https://ieeexplore.ieee.org/document/10886941/.
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