Multi-parameter label-free biosensing with self-assembled smart biolayers that transform each sensing channel into a multiplex channel

Smart biomolecular layers that self-assemble on a sensor chip and can logically analyze a presence of several different molecules in the microenvironment to generate a response are developed and demonstrated. In contrast to conventional sensor chips for label-free biosensors, analyzing in each channel only one parameter, the channel with smart layer can analyze several parameters simultaneously.