Open Access
IEEE Open Journal of the Solid-State Circuits Society, volume 2, pages 193-207
A 4x4 Biosensor Array with a 42-lW/Channel Multiplexed Current Sensitive Front-end Featuring 137-dB DR and Zeptomolar Sensitivity
Enrico Genco
1
,
Marco Fattori
1
,
Pieter Harpe
1
,
Francesco Modena
2
,
Fabrizio Antonio Viola
2
,
Mario Caironi
2
,
May Wheeler
3
,
Guillaume Fichet
3
,
Fabrizio Torricelli
4
,
Lucia Sarcina
5
,
Eleonora Macchia
5
,
L. Torsi
5
,
Eugenio Cantatore
1
1
3
FlexEnable Ltd., Cambridge, U.K.
|
4
Department of Information Engineering, Università degli Studi di Brescia, Brescia, Italy
|
Publication type: Journal Article
Publication date: 2022-11-07
—
Quartile SCImago
— Quartile WOS
—
Impact factor: —
ISSN: 26441349
Abstract
This paper presents a multiplexed current sensitive readout for label-free zeptomolar-sensitive detectors realized with large area Electrolyte Gated Organic Thin Film Transistors (EGOFETs). These highly capacitive biosensors are multiplexed using an OTFT line driver and OTFT switches, and interfaced to a 65-nm Si CMOS, low power, pA-sensitive front-end. The Si chip performs analogue-to-digital conversion and data transmission to a microcontroller too. A current domain interface is used to transmit the signals coming from multiple biosensors to the 1.2 V-supply CMOS Si-IC via the 30V-supply OTFT electronics. Exploiting an analogue module implemented in the Si-IC, the EGOFETs are precisely biased, even in presence of a large OTFT multiplexer resistance. The CMOS current sensitive front-end achieves a dynamic range (DR) of 137 dB and a power consumption of 42 lW per channel reaching a state-of-the-art DR-power-bandwidth FOM of 208 dB. The front-end has been designed with a first stage programmable-gain, active-feedback transimpedance amplifier topology that, contrary to common current-sensitive front-end solutions, is not affected by the sensor capacitance. The system has been validated with different concentrations of human IgG and IgM proteins using both a single sensor and a 4x4 array of EGOFETs. Thanks to the multiplexing strategy and the low-costs of its modules, the system here presented has the potential to enable widespread use of precision diagnostic with extreme sensitivity even in point-of-care and low-resource settings.
Top-30
Citations by journals
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1
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Analytical and Bioanalytical Chemistry
1 publication, 11.11%
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International Journal of Molecular Sciences
1 publication, 11.11%
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Sensors
1 publication, 11.11%
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Advanced Materials
1 publication, 11.11%
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IEEE Journal of Solid-State Circuits
1 publication, 11.11%
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IEEE Sensors Journal
1 publication, 11.11%
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Russian Chemical Reviews
1 publication, 11.11%
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1
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Citations by publishers
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1
2
3
4
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IEEE
4 publications, 44.44%
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 22.22%
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Springer Nature
1 publication, 11.11%
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Wiley
1 publication, 11.11%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 11.11%
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2
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Genco E. et al. A 4x4 Biosensor Array with a 42-lW/Channel Multiplexed Current Sensitive Front-end Featuring 137-dB DR and Zeptomolar Sensitivity // IEEE Open Journal of the Solid-State Circuits Society. 2022. Vol. 2. pp. 193-207.
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Genco E., Fattori M., Harpe P., Modena F., Viola F. A., Caironi M., Wheeler M., Fichet G., Torricelli F., Sarcina L., Macchia E., Torsi L., Cantatore E. A 4x4 Biosensor Array with a 42-lW/Channel Multiplexed Current Sensitive Front-end Featuring 137-dB DR and Zeptomolar Sensitivity // IEEE Open Journal of the Solid-State Circuits Society. 2022. Vol. 2. pp. 193-207.
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TY - JOUR
DO - 10.1109/ojsscs.2022.3217231
UR - https://doi.org/10.1109/ojsscs.2022.3217231
TI - A 4x4 Biosensor Array with a 42-lW/Channel Multiplexed Current Sensitive Front-end Featuring 137-dB DR and Zeptomolar Sensitivity
T2 - IEEE Open Journal of the Solid-State Circuits Society
AU - Genco, Enrico
AU - Fattori, Marco
AU - Harpe, Pieter
AU - Modena, Francesco
AU - Viola, Fabrizio Antonio
AU - Caironi, Mario
AU - Wheeler, May
AU - Fichet, Guillaume
AU - Torricelli, Fabrizio
AU - Sarcina, Lucia
AU - Macchia, Eleonora
AU - Torsi, L.
AU - Cantatore, Eugenio
PY - 2022
DA - 2022/11/07 00:00:00
SP - 193-207
VL - 2
SN - 2644-1349
ER -
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@article{2022_Genco,
author = {Enrico Genco and Marco Fattori and Pieter Harpe and Francesco Modena and Fabrizio Antonio Viola and Mario Caironi and May Wheeler and Guillaume Fichet and Fabrizio Torricelli and Lucia Sarcina and Eleonora Macchia and L. Torsi and Eugenio Cantatore},
title = {A 4x4 Biosensor Array with a 42-lW/Channel Multiplexed Current Sensitive Front-end Featuring 137-dB DR and Zeptomolar Sensitivity},
journal = {IEEE Open Journal of the Solid-State Circuits Society},
year = {2022},
volume = {2},
month = {nov},
url = {https://doi.org/10.1109/ojsscs.2022.3217231},
pages = {193--207},
doi = {10.1109/ojsscs.2022.3217231}
}
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