Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model
Тип публикации: Journal Article
Дата публикации: 2022-04-01
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 2.501
CiteScore: 18.7
Impact factor: 12.4
ISSN: 02780062, 15580062, 1558254X
PubMed ID:
34807820
Computer Science Applications
Electrical and Electronic Engineering
Radiological and Ultrasound Technology
Software
Краткое описание
The minimum histological criterion for the diagnostics of Alzheimer’s disease (AD) in tissue is the presence of senile plaques and neurofibrillary tangles in specific brain locations. The routine procedure of morphological analysis implies time-consuming and laborious steps including sectioning and staining of formalin-fixed paraffin-embedded (FFPE) tissue. We developed a multispectral Stokes polarimetric imaging approach that allows characterization of FFPE brain tissue samples to discern the stages of AD progression without sectioning and staining the tissue. The Stokes polarimetry approach is highly sensitive to structural alterations of brain tissue, particularly to the changes in light scattering and birefringence. We present the results of the label-free non-destructive screening of FFPE mouse brain tissue and show several polarization metrics that demonstrate statistically significant differences for tissues at different stages of AD.
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ГОСТ
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Borovkova M. A. et al. Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model // IEEE Transactions on Medical Imaging. 2022. Vol. 41. No. 4. pp. 977-982.
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Borovkova M. A., Sieryi O., Lopushenko I., Kartashkina N., Pahnke J., Bykov A. V., Meglinski I. Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model // IEEE Transactions on Medical Imaging. 2022. Vol. 41. No. 4. pp. 977-982.
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TY - JOUR
DO - 10.1109/TMI.2021.3129700
UR - https://doi.org/10.1109/TMI.2021.3129700
TI - Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model
T2 - IEEE Transactions on Medical Imaging
AU - Borovkova, Mariia A.
AU - Sieryi, Oleksii
AU - Lopushenko, Ivan
AU - Kartashkina, Natalia
AU - Pahnke, Jens
AU - Bykov, Alexander V.
AU - Meglinski, Igor
PY - 2022
DA - 2022/04/01
PB - Institute of Electrical and Electronics Engineers (IEEE)
SP - 977-982
IS - 4
VL - 41
PMID - 34807820
SN - 0278-0062
SN - 1558-0062
SN - 1558-254X
ER -
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BibTex (до 50 авторов)
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@article{2022_Borovkova,
author = {Mariia A. Borovkova and Oleksii Sieryi and Ivan Lopushenko and Natalia Kartashkina and Jens Pahnke and Alexander V. Bykov and Igor Meglinski},
title = {Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model},
journal = {IEEE Transactions on Medical Imaging},
year = {2022},
volume = {41},
publisher = {Institute of Electrical and Electronics Engineers (IEEE)},
month = {apr},
url = {https://doi.org/10.1109/TMI.2021.3129700},
number = {4},
pages = {977--982},
doi = {10.1109/TMI.2021.3129700}
}
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MLA
Скопировать
Borovkova, Mariia A., et al. “Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model.” IEEE Transactions on Medical Imaging, vol. 41, no. 4, Apr. 2022, pp. 977-982. https://doi.org/10.1109/TMI.2021.3129700.
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