Institute of Electrical and Electronics Engineers (IEEE)

IEEE Transactions on Medical Imaging

, volume 41 , issue 4 , pages 977-982

Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model

Mariia A. Borovkova ¹

Oleksii Sieryi ¹

Ivan Lopushenko ¹

Natalia Kartashkina ²

Jens Pahnke ³

Alexander V. Bykov ¹

Igor Meglinski ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland |

Histology, Cytology and Embryology Department, I. M. Sechenov First Moscow State Medical University, Moscow, Russia |

Department of Pathology, Section of Neuropathology, University of Oslo & Oslo University Hospital, Nydalen, Oslo, Norway |

Publication type: Journal Article

Publication date: 2022-04-01

Institute of Electrical and Electronics Engineers (IEEE)

IEEE Transactions on Medical Imaging

scimago Q1

wos Q1

SJR: 2.629

CiteScore: 18.3

Impact factor: 9.8

ISSN: 02780062, 15580062, 1558254X

DOI: 10.1109/TMI.2021.3129700

Copy DOI

PubMed ID: 34807820

Computer Science Applications

Electrical and Electronic Engineering

Radiological and Ultrasound Technology

Software

Abstract

The minimum histological criterion for the diagnostics of Alzheimer’s disease (AD) in tissue is the presence of senile plaques and neurofibrillary tangles in specific brain locations. The routine procedure of morphological analysis implies time-consuming and laborious steps including sectioning and staining of formalin-fixed paraffin-embedded (FFPE) tissue. We developed a multispectral Stokes polarimetric imaging approach that allows characterization of FFPE brain tissue samples to discern the stages of AD progression without sectioning and staining the tissue. The Stokes polarimetry approach is highly sensitive to structural alterations of brain tissue, particularly to the changes in light scattering and birefringence. We present the results of the label-free non-destructive screening of FFPE mouse brain tissue and show several polarization metrics that demonstrate statistically significant differences for tissues at different stages of AD.

Found

1 citation

Vaganova Anastasia

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37 publications, 169 citations, 1 review

h-index: 10

Saint Petersburg State University

Research interests

Antimicrobial resistance

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GOST |

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GOST Copy

Borovkova M. A. et al. Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model // IEEE Transactions on Medical Imaging. 2022. Vol. 41. No. 4. pp. 977-982.

GOST all authors (up to 50) Copy

Borovkova M. A., Sieryi O., Lopushenko I., Kartashkina N., Pahnke J., Bykov A. V., Meglinski I. Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model // IEEE Transactions on Medical Imaging. 2022. Vol. 41. No. 4. pp. 977-982.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1109/TMI.2021.3129700

UR - https://doi.org/10.1109/TMI.2021.3129700

TI - Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model

T2 - IEEE Transactions on Medical Imaging

AU - Borovkova, Mariia A.

AU - Sieryi, Oleksii

AU - Lopushenko, Ivan

AU - Kartashkina, Natalia

AU - Pahnke, Jens

AU - Bykov, Alexander V.

AU - Meglinski, Igor

PY - 2022

DA - 2022/04/01

PB - Institute of Electrical and Electronics Engineers (IEEE)

SP - 977-982

IS - 4

VL - 41

PMID - 34807820

SN - 0278-0062

SN - 1558-0062

SN - 1558-254X

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2022_Borovkova,

author = {Mariia A. Borovkova and Oleksii Sieryi and Ivan Lopushenko and Natalia Kartashkina and Jens Pahnke and Alexander V. Bykov and Igor Meglinski},

title = {Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model},

journal = {IEEE Transactions on Medical Imaging},

year = {2022},

volume = {41},

publisher = {Institute of Electrical and Electronics Engineers (IEEE)},

month = {apr},

url = {https://doi.org/10.1109/TMI.2021.3129700},

number = {4},

pages = {977--982},

doi = {10.1109/TMI.2021.3129700}

}

MLA

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MLA Copy

Borovkova, Mariia A., et al. “Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model.” IEEE Transactions on Medical Imaging, vol. 41, no. 4, Apr. 2022, pp. 977-982. https://doi.org/10.1109/TMI.2021.3129700.

Publisher

Institute of Electrical and Electronics Engineers (IEEE)

Journal

IEEE Transactions on Medical Imaging

scimago Q1

wos Q1

SJR

2.629

CiteScore

18.3

Impact factor

9.8

ISSN

02780062 (Print)

15580062 (Electronic)

1558254X (Electronic)

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