CHEMICAL DESIGN OF PERIPHERALLY ACTING COMPOUNDS
Publication type: Journal Article
Publication date: 1992-01-01
scimago Q2
wos Q2
SJR: 0.625
CiteScore: 5.5
Impact factor: 2.5
ISSN: 03051870, 14401681
PubMed ID:
1623633
Pharmacology
Physiology
Physiology (medical)
Abstract
1. Some guanidines, related in structure to mianserin and to 2-methyl-1,2,9,13b-tetrahydro-3H-dibenz[c,f]imadazo[1,5a] azepin-3-imine hydrobromide (WAL 801), have been synthesized and shown to be peripherally acting 5-HT2 antagonists. Structurally related compounds but not bearing a charged ionic group have been shown to have central activity. 2. Computer-aided molecular modelling has been used to establish a 5-HT2 pharmacophore. 3. The principle of exclusion from the CNS by incorporating a highly polar group to a biologically active molecule has been extended to the design and synthesis of a peripherally acting analgesic.
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Total citations:
8
Citations from 2024:
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Jackson W. R. et al. CHEMICAL DESIGN OF PERIPHERALLY ACTING COMPOUNDS // Clinical and Experimental Pharmacology and Physiology. 1992. Vol. 19. No. 1. pp. 17-23.
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Jackson W. R., Copp F. C., Cullen J. D., Guyett F. J., Rae I., Robinson A. J., Pothoulackis H., Serelis A. K., WONG M. CHEMICAL DESIGN OF PERIPHERALLY ACTING COMPOUNDS // Clinical and Experimental Pharmacology and Physiology. 1992. Vol. 19. No. 1. pp. 17-23.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1111/j.1440-1681.1992.tb00392.x
UR - https://doi.org/10.1111/j.1440-1681.1992.tb00392.x
TI - CHEMICAL DESIGN OF PERIPHERALLY ACTING COMPOUNDS
T2 - Clinical and Experimental Pharmacology and Physiology
AU - Jackson, W. Roy
AU - Copp, Fred C
AU - Cullen, John D
AU - Guyett, Frances J
AU - Rae, Ian
AU - Robinson, Andrea J.
AU - Pothoulackis, Helen
AU - Serelis, Algirdas K.
AU - WONG, MARGARET
PY - 1992
DA - 1992/01/01
PB - Wiley
SP - 17-23
IS - 1
VL - 19
PMID - 1623633
SN - 0305-1870
SN - 1440-1681
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1992_Jackson,
author = {W. Roy Jackson and Fred C Copp and John D Cullen and Frances J Guyett and Ian Rae and Andrea J. Robinson and Helen Pothoulackis and Algirdas K. Serelis and MARGARET WONG},
title = {CHEMICAL DESIGN OF PERIPHERALLY ACTING COMPOUNDS},
journal = {Clinical and Experimental Pharmacology and Physiology},
year = {1992},
volume = {19},
publisher = {Wiley},
month = {jan},
url = {https://doi.org/10.1111/j.1440-1681.1992.tb00392.x},
number = {1},
pages = {17--23},
doi = {10.1111/j.1440-1681.1992.tb00392.x}
}
Cite this
MLA
Copy
Jackson, W. Roy, et al. “CHEMICAL DESIGN OF PERIPHERALLY ACTING COMPOUNDS.” Clinical and Experimental Pharmacology and Physiology, vol. 19, no. 1, Jan. 1992, pp. 17-23. https://doi.org/10.1111/j.1440-1681.1992.tb00392.x.