Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats
Publication type: Journal Article
Publication date: 2005-10-01
scimago Q2
wos Q3
SJR: 0.689
CiteScore: 5.3
Impact factor: 2.5
ISSN: 07673981, 14728206
PubMed ID:
16176335
Pharmacology
Pharmacology (medical)
Abstract
The effect of N-benzoyl-d-phenylalanine (NBDP) and metformin combination treatment on liver lipids and lipid peroxidation markers was studied in neonatal streptozotocin (nSTZ) diabetic rats. Oral administration of NBDP (50, 100 and 200 mg/kg body weight) and metformin (500 mg/kg body weight) for 6 weeks significantly reduced the elevated blood glucose, liver cholesterol, triglycerides, free fatty acids and phospholipids. The combination treatment also caused a significant decrease in hepatic hydroxymethyl glutaryl-coenzyme A reductase, Thiobarbituric Acid Reactive Substances (TBARS) and significant increase in reduced glutathione levels. The results show that NBDP and metformin improve the hepatic lipid profile and antioxidant status in nSTZ diabetic rats. Combination treatment was more effective than either drug alone.
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GOST
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Pari L., Ashokkumar N. Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats // Fundamental and Clinical Pharmacology. 2005. Vol. 19. No. 5. pp. 563-568.
GOST all authors (up to 50)
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Pari L., Ashokkumar N. Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats // Fundamental and Clinical Pharmacology. 2005. Vol. 19. No. 5. pp. 563-568.
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RIS
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TY - JOUR
DO - 10.1111/j.1472-8206.2005.00366.x
UR - https://doi.org/10.1111/j.1472-8206.2005.00366.x
TI - Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats
T2 - Fundamental and Clinical Pharmacology
AU - Pari, Leelavinothan
AU - Ashokkumar, Natarajan
PY - 2005
DA - 2005/10/01
PB - Wiley
SP - 563-568
IS - 5
VL - 19
PMID - 16176335
SN - 0767-3981
SN - 1472-8206
ER -
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BibTex (up to 50 authors)
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@article{2005_Pari,
author = {Leelavinothan Pari and Natarajan Ashokkumar},
title = {Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats},
journal = {Fundamental and Clinical Pharmacology},
year = {2005},
volume = {19},
publisher = {Wiley},
month = {oct},
url = {https://doi.org/10.1111/j.1472-8206.2005.00366.x},
number = {5},
pages = {563--568},
doi = {10.1111/j.1472-8206.2005.00366.x}
}
Cite this
MLA
Copy
Pari, Leelavinothan, and Natarajan Ashokkumar. “Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats.” Fundamental and Clinical Pharmacology, vol. 19, no. 5, Oct. 2005, pp. 563-568. https://doi.org/10.1111/j.1472-8206.2005.00366.x.