Impaired autoregulation of cerebral blood flow in long-term Type I (insulin-dependent) diabetic patients with nephropathy and retinopathy
1
*Department of Clinical Physiology/Nuclear Medicine
2
†Anaesthesiology, Bispebjerg Hospital, Copenhagen
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3
†Hvidöre Hospital, Klampenborg, Denmark
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Publication type: Journal Article
Publication date: 2008-06-28
PubMed ID:
3791893
Physiology
Abstract
Autoregulation of cerebral blood flow, i.e., the maintenance of cerebral blood flow within narrow limits during changes in arterial perfusion pressure, was studied in nine healthy control subjects and in 12 long-term Type I (insulin-dependent) diabetic patients with clinical microangiopathy. Cerebral blood flow was measured by the intravenous 133Xenon method. Mean arterial blood pressure was elevated approximately 30 mmHg by intravenous infusion of angiotensin amide II and lowered about 10 mmHg by intravenous infusion of trimethaphan camsylate. In the control subjects the flow/pressure curve was horizontal indicating perfect autoregulation. In the diabetic patients the flow/pressure curve showed a significant slope with a 1.9% change in CBF per 10 mmHg change in mean arterial blood pressure as compared to a slope value of -0.4% in the control subjects (P less than 0.05). Our results confirm the previous findings suggesting that autoregulation of cerebral blood flow is impaired in some long-term Type I diabetic patients with clinical microangiopathy (arteriolar hyalinosis).
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Kastrup J. et al. Impaired autoregulation of cerebral blood flow in long-term Type I (insulin-dependent) diabetic patients with nephropathy and retinopathy // Clinical Physiology. 2008. Vol. 6. No. 6. pp. 549-559.
GOST all authors (up to 50)
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Kastrup J., Rørsgaard S., Parving H. H., Lassen N. A. Impaired autoregulation of cerebral blood flow in long-term Type I (insulin-dependent) diabetic patients with nephropathy and retinopathy // Clinical Physiology. 2008. Vol. 6. No. 6. pp. 549-559.
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TY - JOUR
DO - 10.1111/j.1475-097x.1986.tb00788.x
UR - https://doi.org/10.1111/j.1475-097x.1986.tb00788.x
TI - Impaired autoregulation of cerebral blood flow in long-term Type I (insulin-dependent) diabetic patients with nephropathy and retinopathy
T2 - Clinical Physiology
AU - Kastrup, J
AU - Rørsgaard, S
AU - Parving, H H
AU - Lassen, N. A.
PY - 2008
DA - 2008/06/28
PB - Wiley
SP - 549-559
IS - 6
VL - 6
PMID - 3791893
SN - 0144-5979
SN - 1365-2281
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2008_Kastrup,
author = {J Kastrup and S Rørsgaard and H H Parving and N. A. Lassen},
title = {Impaired autoregulation of cerebral blood flow in long-term Type I (insulin-dependent) diabetic patients with nephropathy and retinopathy},
journal = {Clinical Physiology},
year = {2008},
volume = {6},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1111/j.1475-097x.1986.tb00788.x},
number = {6},
pages = {549--559},
doi = {10.1111/j.1475-097x.1986.tb00788.x}
}
Cite this
MLA
Copy
Kastrup, J., et al. “Impaired autoregulation of cerebral blood flow in long-term Type I (insulin-dependent) diabetic patients with nephropathy and retinopathy.” Clinical Physiology, vol. 6, no. 6, Jun. 2008, pp. 549-559. https://doi.org/10.1111/j.1475-097x.1986.tb00788.x.