Wiley
Respirology
,  volume 30 ,  issue 4 ,  pages 346-358

Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia

Yunqing Zhu 1
, 
Yongbing Lan 1
, 
Jun Lv 1, 2, 3
, 
Dianjianyi Sun 1, 2, 3
, 
Pei Pei 2
, 
Ling Yang 4, 5
, 
Iona Y. Millwood 4, 5
, 
Robin G. Walters 4, 5
, 
Yiping Chen 4, 5
, 
Huaidong Du 4, 5
, 
Jian Wang 6
, 
Xiaoming Yang 5
, 
Rebecca Stevens 5
, 
Junshi Chen 7
, 
Zhengming Chen 5
, 
Liming Li 1, 2, 3
, 
Canqing Yu 1, 2, 3
1
 
2
 
3
 
4
 
5
 
6
 
7
 
China National Center for Food Safety Risk Assessment Beijing China | 
Publication type: Journal Article
Publication date: 2025-02-05
Wiley
scimago Q1
wos Q1
SJR: 1.570
CiteScore: 10.3
Impact factor: 6.3
ISSN: 13237799, 14401843
Abstract
ABSTRACT
Background and Objective

Previous observational studies reported a complex relationship between snoring and coronary artery disease (CAD). We aimed to estimate the causal associations between snoring and CAD among East Asian people, and the effects independent of BMI.

Methods

Based on 497,250 adults from China Kadoorie Biobank (CKB), we performed a conventional prospective analysis between snoring and CAD outcomes, using the multivariable Cox regression. We also leveraged genome‐wide association (GWAS) summary statistics of snoring and BMI from CKB (n = 100,626, 47,208 snorers) and CAD outcomes from Biobank of Japan (BBJ, 5891–25,892 cases, 142,336–168,186 controls). Single‐variable and multivariable two‐sample bi‐directional Mendelian randomization (MR) analyses were performed.

Results

During a median follow‐up of 12.32 years, 48,997 participants developed CAD. Snoring and habitual snoring were associated with incident CAD and myocardial infarction (MI), habitual snoring was also associated with stable angina pectoris (SAP). The HRs (95% CIs) of habitual snoring were 1.06 (1.04, 1.08), 1.06 (1.04, 1.08) and 1.14 (1.03, 1.25). The associations remained among non‐adiposity participants. Genetically predicted habitual snoring was associated with CAD and MI, the corresponding IVW‐ORs (95% CIs) were 1.09 (1.005, 1.19) and 1.15 (1.05, 1.25). Further adjusted BMI, habitual snoring retained independent effects on MI and CAD, and showed impact on SAP (1.09 [1.01, 1.17]). No reverse associations were observed between CADs on snoring traits.

Conclusion

Habitual snoring elevated the risks of total CAD, MI and SAP. The causal associations were independent of BMI. These findings indicated that snoring intervention might contribute to the decrease of CAD risk among Asians.

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GOST Copy
Zhu Y. et al. Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia // Respirology. 2025. Vol. 30. No. 4. pp. 346-358.
GOST all authors (up to 50) Copy
Zhu Y., Lan Y., Lv J., Sun D., Pei P., Yang L., Millwood I. Y., Walters R. G., Chen Y., Du H., Wang J., Yang X., Stevens R., Chen J., Chen Z., Li L., Yu C. Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia // Respirology. 2025. Vol. 30. No. 4. pp. 346-358.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1111/resp.14893
UR - https://onlinelibrary.wiley.com/doi/10.1111/resp.14893
TI - Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia
T2 - Respirology
AU - Zhu, Yunqing
AU - Lan, Yongbing
AU - Lv, Jun
AU - Sun, Dianjianyi
AU - Pei, Pei
AU - Yang, Ling
AU - Millwood, Iona Y.
AU - Walters, Robin G.
AU - Chen, Yiping
AU - Du, Huaidong
AU - Wang, Jian
AU - Yang, Xiaoming
AU - Stevens, Rebecca
AU - Chen, Junshi
AU - Chen, Zhengming
AU - Li, Liming
AU - Yu, Canqing
PY - 2025
DA - 2025/02/05
PB - Wiley
SP - 346-358
IS - 4
VL - 30
SN - 1323-7799
SN - 1440-1843
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Zhu,
author = {Yunqing Zhu and Yongbing Lan and Jun Lv and Dianjianyi Sun and Pei Pei and Ling Yang and Iona Y. Millwood and Robin G. Walters and Yiping Chen and Huaidong Du and Jian Wang and Xiaoming Yang and Rebecca Stevens and Junshi Chen and Zhengming Chen and Liming Li and Canqing Yu},
title = {Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia},
journal = {Respirology},
year = {2025},
volume = {30},
publisher = {Wiley},
month = {feb},
url = {https://onlinelibrary.wiley.com/doi/10.1111/resp.14893},
number = {4},
pages = {346--358},
doi = {10.1111/resp.14893}
}
MLA
Cite this
MLA Copy
Zhu, Yunqing, et al. “Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia.” Respirology, vol. 30, no. 4, Feb. 2025, pp. 346-358. https://onlinelibrary.wiley.com/doi/10.1111/resp.14893.