Alimentary Pharmacology and Therapeutics, volume 47, issue 12, pages 1597-1609

Systematic review: safety of mesalazine in ulcerative colitis

Priya Sehgal ¹

Jean-Frédéric Colombel ¹

A Aboubakr ²

Neeraj Narula ³

Hide authors affiliations Show authors affiliations: 3 affiliations

Division of Gastroenterology; Icahn School of Medicine at Mount Sinai; New York NY USA |

Icahn School of Medicine at Mount Sinai; New York NY USA |

Department of Medicine; Division of Gastroenterology; Farncombe Family Digestive Health Research Institute; McMaster University; Hamilton ON Canada |

Publication type: Journal Article

Publication date: 2018-05-03

Wiley

Journal: Alimentary Pharmacology and Therapeutics

Quartile SCImago

Quartile WOS

Impact factor: 7.6

ISSN: 02692813, 13652036

DOI: 10.1111/apt.14688

Copy DOI

Pharmacology (medical)

Gastroenterology

Hepatology

Abstract

Mesalazine is the most commonly prescribed medication for mild to moderate ulcerative colitis. It is generally well tolerated with some reported side effects.To summarise adverse drug events to mesalazine and recommend techniques for management. Furthermore, to determine if there is a dose-dependent relationship between high (>2.4 g/day) vs low dosing (≤2.4 g/day) and occurrence of adverse drug events.A literature search for relevant studies from inception to 1 December 2017 of the MEDLINE database was conducted. Two reviewers screened all titles identified. Data obtained from randomised controlled trials was used to estimate incidence rates of each adverse event. Two reviewers independently assessed methodological risk of bias and performed data extraction.3581 articles were initially considered. Of these, 3573 were screened, 622 reviewed and 91 included. Adverse events attributed to mesalazine included inflammatory reactions, pancreatitis, cardiotoxicity, hepatotoxicity, musculoskeletal complaints, respiratory symptoms, nephropathies and sexual dysfunction. There does not appear to be a dose-dependent relationship of mesalazine and occurrence of adverse events.Patients on mesalazine should be monitored for worsening of ulcerative colitis and development of new onset organ dysfunction. High-dose mesalazine appears to have similar safety profile as low dose, and is not associated with greater risk of adverse events. Prior to placing a patient on mesalazine, baseline liver and renal function should be evaluated. Renal function should be periodically assessed, whereas other testing should be performed depending on development of symptoms.

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Sehgal P. et al. Systematic review: safety of mesalazine in ulcerative colitis // Alimentary Pharmacology and Therapeutics. 2018. Vol. 47. No. 12. pp. 1597-1609.

GOST all authors (up to 50) Copy

Sehgal P., Colombel J., Aboubakr A., Narula N. Systematic review: safety of mesalazine in ulcerative colitis // Alimentary Pharmacology and Therapeutics. 2018. Vol. 47. No. 12. pp. 1597-1609.

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TY - JOUR

DO - 10.1111/apt.14688

UR - https://doi.org/10.1111/apt.14688

TI - Systematic review: safety of mesalazine in ulcerative colitis

T2 - Alimentary Pharmacology and Therapeutics

AU - Aboubakr, A

AU - Colombel, Jean-Frédéric

AU - Narula, Neeraj

AU - Sehgal, Priya

PY - 2018

DA - 2018/05/03 00:00:00

PB - Wiley

SP - 1597-1609

IS - 12

VL - 47

SN - 0269-2813

SN - 1365-2036

ER -

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@article{2018_Sehgal,

author = {A Aboubakr and Jean-Frédéric Colombel and Neeraj Narula and Priya Sehgal},

title = {Systematic review: safety of mesalazine in ulcerative colitis},

journal = {Alimentary Pharmacology and Therapeutics},

year = {2018},

volume = {47},

publisher = {Wiley},

month = {may},

url = {https://doi.org/10.1111/apt.14688},

number = {12},

pages = {1597--1609},

doi = {10.1111/apt.14688}

}

MLA

Cite this

MLA Copy

Sehgal, Priya, et al. “Systematic review: safety of mesalazine in ulcerative colitis.” Alimentary Pharmacology and Therapeutics, vol. 47, no. 12, May. 2018, pp. 1597-1609. https://doi.org/10.1111/apt.14688.

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Publisher

Wiley

Journal

Alimentary Pharmacology and Therapeutics

Quartile SCImago

Quartile WOS

Impact factor

7.6

ISSN

02692813 (Print)
13652036 (Electronic)