Design, Synthesis, and Biological Evaluation ofγ-Aminopropyl Silatrane-Acyclovir Hybrids with Immunomodulatory Effects
Faqing Ye
1
,
Xiaoqin Song
1
,
Jianmin Liu
1
,
Xuemei Xu
2
,
Yuewu Wang
1
,
Lichuan Hu
3
,
Yi Wang
1
,
Guang Liang
1
,
Ping Guo
1
,
Zixin Xie
1
2
Wenzhou City Hospital of Traditional Chinese Medicine and Western Medicine Combined; Wenzhou Zhejiang 325000 China
|
3
Wenzhou Central Hospital; Wenzhou Zhejiang 325000 China
|
Publication type: Journal Article
Publication date: 2015-02-16
scimago Q2
wos Q2
SJR: 0.689
CiteScore: 5.6
Impact factor: 3.3
ISSN: 17470277, 17470285
PubMed ID:
25599975
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
Abstract
Several derivatives of γ-aminopropyl silatrane containing acyclovir in their molecular structure were synthesized and evaluated for their immunomodulatory and antiviral activities. The structures of all these derivatives were confirmed by mass spectra, IR, and (1) H NMR. Based on WST-1 assay in vitro, these compounds could stimulate proliferation of splenic lymphocytes at certain concentrations. Furthermore, compound 3d could also potentiate the expression of IFN-γ, IL-2, CD4(+) , CD8(+) , and CD4(+) /CD8(+) in vivo. Our results show that these derivatives possess antiviral activity against herpes simplex viruses with a similar potency to acyclovir without a cellular immune response.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
|
|
|
Mendeleev Communications
4 publications, 19.05%
|
|
|
Molecules
2 publications, 9.52%
|
|
|
Russian Chemical Bulletin
2 publications, 9.52%
|
|
|
Journal of Organometallic Chemistry
2 publications, 9.52%
|
|
|
Applied Organometallic Chemistry
2 publications, 9.52%
|
|
|
Pharmaceutics
1 publication, 4.76%
|
|
|
Protection of Metals and Physical Chemistry of Surfaces
1 publication, 4.76%
|
|
|
New Journal of Chemistry
1 publication, 4.76%
|
|
|
ACS Sustainable Chemistry and Engineering
1 publication, 4.76%
|
|
|
RSC Medicinal Chemistry
1 publication, 4.76%
|
|
|
Russian Journal of Organic Chemistry
1 publication, 4.76%
|
|
|
Computational and Theoretical Chemistry
1 publication, 4.76%
|
|
|
Advances in Colloid and Interface Science
1 publication, 4.76%
|
|
|
Inorganic Chemistry
1 publication, 4.76%
|
|
|
1
2
3
4
|
Publishers
|
1
2
3
4
|
|
|
Elsevier
4 publications, 19.05%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
4 publications, 19.05%
|
|
|
MDPI
3 publications, 14.29%
|
|
|
Springer Nature
2 publications, 9.52%
|
|
|
Wiley
2 publications, 9.52%
|
|
|
Pleiades Publishing
2 publications, 9.52%
|
|
|
Royal Society of Chemistry (RSC)
2 publications, 9.52%
|
|
|
American Chemical Society (ACS)
2 publications, 9.52%
|
|
|
1
2
3
4
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
21
Total citations:
21
Citations from 2025:
4
(19.05%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Ye F. et al. Design, Synthesis, and Biological Evaluation ofγ-Aminopropyl Silatrane-Acyclovir Hybrids with Immunomodulatory Effects // Chemical Biology and Drug Design. 2015. Vol. 86. No. 4. pp. 905-910.
GOST all authors (up to 50)
Copy
Ye F., Song X., Liu J., Xu X., Wang Y., Hu L., Wang Y., Liang G., Guo P., Xie Z. Design, Synthesis, and Biological Evaluation ofγ-Aminopropyl Silatrane-Acyclovir Hybrids with Immunomodulatory Effects // Chemical Biology and Drug Design. 2015. Vol. 86. No. 4. pp. 905-910.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1111/cbdd.12519
UR - https://doi.org/10.1111/cbdd.12519
TI - Design, Synthesis, and Biological Evaluation ofγ-Aminopropyl Silatrane-Acyclovir Hybrids with Immunomodulatory Effects
T2 - Chemical Biology and Drug Design
AU - Ye, Faqing
AU - Song, Xiaoqin
AU - Liu, Jianmin
AU - Xu, Xuemei
AU - Wang, Yuewu
AU - Hu, Lichuan
AU - Wang, Yi
AU - Liang, Guang
AU - Guo, Ping
AU - Xie, Zixin
PY - 2015
DA - 2015/02/16
PB - Wiley
SP - 905-910
IS - 4
VL - 86
PMID - 25599975
SN - 1747-0277
SN - 1747-0285
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Ye,
author = {Faqing Ye and Xiaoqin Song and Jianmin Liu and Xuemei Xu and Yuewu Wang and Lichuan Hu and Yi Wang and Guang Liang and Ping Guo and Zixin Xie},
title = {Design, Synthesis, and Biological Evaluation ofγ-Aminopropyl Silatrane-Acyclovir Hybrids with Immunomodulatory Effects},
journal = {Chemical Biology and Drug Design},
year = {2015},
volume = {86},
publisher = {Wiley},
month = {feb},
url = {https://doi.org/10.1111/cbdd.12519},
number = {4},
pages = {905--910},
doi = {10.1111/cbdd.12519}
}
Cite this
MLA
Copy
Ye, Faqing, et al. “Design, Synthesis, and Biological Evaluation ofγ-Aminopropyl Silatrane-Acyclovir Hybrids with Immunomodulatory Effects.” Chemical Biology and Drug Design, vol. 86, no. 4, Feb. 2015, pp. 905-910. https://doi.org/10.1111/cbdd.12519.