Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives
Xing-Hua Zhen
1, 2
,
Ying-Chun Quan
3
,
Peng Zhou
1, 2
,
Han Yan
4
,
Zhou-Jun Zheng
4
,
Li-Ping Guan
1, 2
2
Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products; Zhoushan Zhejiang 316022 China
|
3
College of Medicine; Yanbian University; Park Street 977 Yanji Jilin 133002 China
|
Publication type: Journal Article
Publication date: 2016-01-26
scimago Q2
wos Q2
SJR: 0.689
CiteScore: 5.6
Impact factor: 3.3
ISSN: 17470277, 17470285
PubMed ID:
26705885
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
Abstract
A series of 7-prenyloxy-2, 3-dihydroflavanone derivatives were synthesized and screened for their antidepressant-like activity. Among them, it was observed that compounds 5j and 5k were found to be the most antidepressant-like activity. In addition, it was found that compounds 5j and 5k significantly increased the concentrations of the main neurotransmitters 5-HT and NE in the hippocampus, hypothalamus, and cortex. Compounds 5j and 5k also significantly increased the contents of 5-HIAA in the hippocampus and cortex, shut down 5-HT metabolism compared with mice treated with stress vehicle. These results suggested that compounds 5j and 5k displayed potent antidepressant-like properties that were mediated via neurochemical systems.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
Medicinal Chemistry Research
2 publications, 16.67%
|
|
|
Bioorganic and Medicinal Chemistry Letters
2 publications, 16.67%
|
|
|
European Journal of Medicinal Chemistry
1 publication, 8.33%
|
|
|
Journal of Organic Chemistry
1 publication, 8.33%
|
|
|
Studies in Natural Products Chemistry
1 publication, 8.33%
|
|
|
Brazilian Journal of Pharmaceutical Sciences
1 publication, 8.33%
|
|
|
Mendeleev Communications
1 publication, 8.33%
|
|
|
RSC Medicinal Chemistry
1 publication, 8.33%
|
|
|
1
2
|
Publishers
|
1
2
3
4
|
|
|
Elsevier
4 publications, 33.33%
|
|
|
Springer Nature
2 publications, 16.67%
|
|
|
American Chemical Society (ACS)
1 publication, 8.33%
|
|
|
1 publication, 8.33%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 8.33%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 8.33%
|
|
|
1
2
3
4
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
12
Total citations:
12
Citations from 2025:
1
(8.33%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Zhen X. et al. Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives // Chemical Biology and Drug Design. 2016. Vol. 87. No. 6. pp. 858-866.
GOST all authors (up to 50)
Copy
Zhen X., Quan Y., Zhou P., Yan H., Zheng Z., Guan L. Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives // Chemical Biology and Drug Design. 2016. Vol. 87. No. 6. pp. 858-866.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1111/cbdd.12717
UR - https://doi.org/10.1111/cbdd.12717
TI - Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives
T2 - Chemical Biology and Drug Design
AU - Zhen, Xing-Hua
AU - Quan, Ying-Chun
AU - Zhou, Peng
AU - Yan, Han
AU - Zheng, Zhou-Jun
AU - Guan, Li-Ping
PY - 2016
DA - 2016/01/26
PB - Wiley
SP - 858-866
IS - 6
VL - 87
PMID - 26705885
SN - 1747-0277
SN - 1747-0285
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Zhen,
author = {Xing-Hua Zhen and Ying-Chun Quan and Peng Zhou and Han Yan and Zhou-Jun Zheng and Li-Ping Guan},
title = {Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives},
journal = {Chemical Biology and Drug Design},
year = {2016},
volume = {87},
publisher = {Wiley},
month = {jan},
url = {https://doi.org/10.1111/cbdd.12717},
number = {6},
pages = {858--866},
doi = {10.1111/cbdd.12717}
}
Cite this
MLA
Copy
Zhen, Xing-Hua, et al. “Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives.” Chemical Biology and Drug Design, vol. 87, no. 6, Jan. 2016, pp. 858-866. https://doi.org/10.1111/cbdd.12717.