Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro
Publication type: Journal Article
Publication date: 2018-10-31
scimago Q2
wos Q2
SJR: 0.689
CiteScore: 5.6
Impact factor: 3.3
ISSN: 17470277, 17470285
PubMed ID:
30218487
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
Abstract
Three components of Camptothecin, hydroxyacetic acid, and functionalized norcantharidins were constructed together to form a novel series of camptothecin derivatives in a good yield. The synthesized campthothecin-HAA-norcantharidin conjugate pro-drugs could suppress cancer cell growth in vitro. These conjugated pro-drug molecules possess therapeutic potential as novel bi-functional conjugates platforms for cancer treatment.
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14
Total citations:
14
Citations from 2025:
1
(7.14%)
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GOST
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Wang X. H. et al. Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro // Chemical Biology and Drug Design. 2018. Vol. 93. No. 6. pp. 986-992.
GOST all authors (up to 50)
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Wang X. H., Huang M., Zhao C., Li C., Xu L. Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro // Chemical Biology and Drug Design. 2018. Vol. 93. No. 6. pp. 986-992.
Cite this
RIS
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TY - JOUR
DO - 10.1111/cbdd.13397
UR - https://doi.org/10.1111/cbdd.13397
TI - Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro
T2 - Chemical Biology and Drug Design
AU - Wang, Xian H.
AU - Huang, Mei
AU - Zhao, Changkuo
AU - Li, Chan
AU - Xu, Lang
PY - 2018
DA - 2018/10/31
PB - Wiley
SP - 986-992
IS - 6
VL - 93
PMID - 30218487
SN - 1747-0277
SN - 1747-0285
ER -
Cite this
BibTex (up to 50 authors)
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@article{2018_Wang,
author = {Xian H. Wang and Mei Huang and Changkuo Zhao and Chan Li and Lang Xu},
title = {Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro},
journal = {Chemical Biology and Drug Design},
year = {2018},
volume = {93},
publisher = {Wiley},
month = {oct},
url = {https://doi.org/10.1111/cbdd.13397},
number = {6},
pages = {986--992},
doi = {10.1111/cbdd.13397}
}
Cite this
MLA
Copy
Wang, Xian H., et al. “Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro.” Chemical Biology and Drug Design, vol. 93, no. 6, Oct. 2018, pp. 986-992. https://doi.org/10.1111/cbdd.13397.