volume 28 issue 12 pages 1345-1353

Experimental Infection in Newborn Mice and Rats by Hemorrhagic Fever with Renal Syndrome (HFRS) Virus

Takahisa Yamanouchi 1, 2
Kayoko Domae 2
Osamu Tanishita 3
Yoshiyuki Takahashi 3
Koichi Yamanishi 4
Michiaki TAKAHASHI 4
Takeshi Kurata 5
Publication typeJournal Article
Publication date1984-12-01
scimago Q3
wos Q4
SJR0.669
CiteScore4.1
Impact factor1.8
ISSN03855600, 13480421
Microbiology
Immunology
Virology
Abstract
Newborn mice and rats were inoculated intracerebrally (ic) or intraperitoneally (ip) with Hantaan virus (76-118 strain) or HFRS-related virus (B-1 strain). The mortality and the influence on the increase of body weight in newborn mice were higher in the groups infected with the 76-118 strain than in the groups infected with the B-1 strain, while the B-1 strain was more virulent in rats than the 76-118 strain. Virus isolation from rats inoculated with either strain was attempted 7 and 11 weeks after inoculation. Virus could be isolated from various organs of rats infected with the B-1 strain, while it was recovered from only the brain and lungs of rats infected with the 76-118 strain. Viral antigen was readily detected in various organs of rats infected with the B-1 strain, but the amount and distribution of antigens were less in rats infected with the 76-118 strain. Our results suggest that the virulence of HFRS-related virus is variable, depending on the species of infected animals as well as on the virus strains. The virus also persists in the injected animals with high titers of antibodies for at least 11 weeks.
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GOST Copy
Yamanouchi T. et al. Experimental Infection in Newborn Mice and Rats by Hemorrhagic Fever with Renal Syndrome (HFRS) Virus // Microbiology and Immunology. 1984. Vol. 28. No. 12. pp. 1345-1353.
GOST all authors (up to 50) Copy
Yamanouchi T., Domae K., Tanishita O., Takahashi Y., Yamanishi K., TAKAHASHI M., Kurata T. Experimental Infection in Newborn Mice and Rats by Hemorrhagic Fever with Renal Syndrome (HFRS) Virus // Microbiology and Immunology. 1984. Vol. 28. No. 12. pp. 1345-1353.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1111/j.1348-0421.1984.tb00792.x
UR - https://doi.org/10.1111/j.1348-0421.1984.tb00792.x
TI - Experimental Infection in Newborn Mice and Rats by Hemorrhagic Fever with Renal Syndrome (HFRS) Virus
T2 - Microbiology and Immunology
AU - Yamanouchi, Takahisa
AU - Domae, Kayoko
AU - Tanishita, Osamu
AU - Takahashi, Yoshiyuki
AU - Yamanishi, Koichi
AU - TAKAHASHI, Michiaki
AU - Kurata, Takeshi
PY - 1984
DA - 1984/12/01
PB - Wiley
SP - 1345-1353
IS - 12
VL - 28
PMID - 6442757
SN - 0385-5600
SN - 1348-0421
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{1984_Yamanouchi,
author = {Takahisa Yamanouchi and Kayoko Domae and Osamu Tanishita and Yoshiyuki Takahashi and Koichi Yamanishi and Michiaki TAKAHASHI and Takeshi Kurata},
title = {Experimental Infection in Newborn Mice and Rats by Hemorrhagic Fever with Renal Syndrome (HFRS) Virus},
journal = {Microbiology and Immunology},
year = {1984},
volume = {28},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1111/j.1348-0421.1984.tb00792.x},
number = {12},
pages = {1345--1353},
doi = {10.1111/j.1348-0421.1984.tb00792.x}
}
MLA
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MLA Copy
Yamanouchi, Takahisa, et al. “Experimental Infection in Newborn Mice and Rats by Hemorrhagic Fever with Renal Syndrome (HFRS) Virus.” Microbiology and Immunology, vol. 28, no. 12, Dec. 1984, pp. 1345-1353. https://doi.org/10.1111/j.1348-0421.1984.tb00792.x.