Open Access

Cancer Science, volume 99, issue 8, pages 1528-1538

Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers

Kyo Satoru ¹

Takakura Masahiro ¹

Fujiwara Toshiyoshi ²

Inoue Masaki ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641 |

Center for Gene and Cell Therapy, Okayama University Hospital, 2‐5‐1 Shikata‐cho, Okayama 700‐8558, Japan |

Publication type: Journal Article

Publication date: 2008-08-14

Wiley

Journal: Cancer Science

Quartile SCImago

Quartile WOS

Impact factor: 5.7

ISSN: 13479032, 13497006

DOI: 10.1111/j.1349-7006.2008.00878.x

Copy DOI

Cancer Research

Oncology

General Medicine

Abstract

Telomerase activation is a critical step for human carcinogenesis through the maintenance of telomeres, but the activation mechanism during carcinogenesis remains unclear. Transcriptional regulation of the human telomerase reverse transcriptase (hTERT) gene is the major mechanism for cancer‐specific activation of telomerase, and a number of factors have been identified to directly or indirectly regulate the hTERT promoter, including cellular transcriptional activators (c‐Myc, Sp1, HIF‐1, AP2, ER, Ets, etc.) as well as the repressors, most of which comprise tumor suppressor gene products, such as p53, WT1, and Menin. Nevertheless, none of them can clearly account for the cancer specificity of hTERT expression. The chromatin structure via the DNA methylation or modulation of nucleosome histones has recently been suggested to be important for regulation of the hTERT promoter. DNA unmethylation or histone methylation around the transcription start site of the hTERT promoter triggers the recruitment of histone acetyltransferase (HAT) activity, allowing hTERT transcription. These facts prompted us to apply these regulatory mechanisms to cancer diagnostics and therapeutics. Telomerase‐specific replicative adenovirus (Telomelysin, OBP‐301), in which E1A and E1B genes are driven by the hTERT promoter, has been developed as an oncolytic virus that replicates specifically in cancer cells and causes cell death via viral toxicity. Direct administration of Telomelysin was proved to effectively eradicate solid tumors in vivo, without apparent adverse effects. Clinical trials using Telomelysin for cancer patients with progressive stages are currently ongoing. Furthermore, we incorporated green fluorescent protein gene (GFP) into Telomelysin (TelomeScan, OBP‐401). Administration of TelomeScan into the primary tumor enabled the visualization of cancer cells under the cooled charged‐coupled device (CCD) camera, not only in primary tumors but also the metastatic foci. This technology can be applied to intraoperative imaging of metastatic lymphnodes. Thus, we found novel tools for cancer diagnostics and therapeutics by utilizing the hTERT promoter. (Cancer Sci 2008; 99: 1528–1538)

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	1 2 3 4 5 6 7 8
Oncotarget	Oncotarget, 8, 2.91% Oncotarget 8 publications, 2.91%
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Genes	Genes, 6, 2.18% Genes 6 publications, 2.18%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 6, 2.18% International Journal of Molecular Sciences 6 publications, 2.18%
International Journal of Cancer	International Journal of Cancer, 6, 2.18% International Journal of Cancer 6 publications, 2.18%
PLoS ONE	PLoS ONE, 5, 1.82% PLoS ONE 5 publications, 1.82%
Cancer Science	Cancer Science, 5, 1.82% Cancer Science 5 publications, 1.82%
Carcinogenesis	Carcinogenesis, 5, 1.82% Carcinogenesis 5 publications, 1.82%
International Journal of Oncology	International Journal of Oncology, 4, 1.45% International Journal of Oncology 4 publications, 1.45%
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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 4, 1.45% Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 4 publications, 1.45%
Journal of Biological Chemistry	Journal of Biological Chemistry, 4, 1.45% Journal of Biological Chemistry 4 publications, 1.45%
Journal of Clinical Investigation	Journal of Clinical Investigation, 3, 1.09% Journal of Clinical Investigation 3 publications, 1.09%
Cells	Cells, 3, 1.09% Cells 3 publications, 1.09%
Journal of Cancer Research and Clinical Oncology	Journal of Cancer Research and Clinical Oncology, 3, 1.09% Journal of Cancer Research and Clinical Oncology 3 publications, 1.09%
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Scientific Reports	Scientific Reports, 3, 1.09% Scientific Reports 3 publications, 1.09%
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Journal of Experimental and Clinical Cancer Research	Journal of Experimental and Clinical Cancer Research, 3, 1.09% Journal of Experimental and Clinical Cancer Research 3 publications, 1.09%
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Oncology Reports	Oncology Reports, 2, 0.73% Oncology Reports 2 publications, 0.73%
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Frontiers in Genetics	Frontiers in Genetics, 2, 0.73% Frontiers in Genetics 2 publications, 0.73%
Cancer Gene Therapy	Cancer Gene Therapy, 2, 0.73% Cancer Gene Therapy 2 publications, 0.73%
Critical Reviews in Oncology/Hematology	Critical Reviews in Oncology/Hematology, 2, 0.73% Critical Reviews in Oncology/Hematology 2 publications, 0.73%
Biochimica et Biophysica Acta - Molecular Cell Research	Biochimica et Biophysica Acta - Molecular Cell Research, 2, 0.73% Biochimica et Biophysica Acta - Molecular Cell Research 2 publications, 0.73%
Biochemical and Biophysical Research Communications	Biochemical and Biophysical Research Communications, 2, 0.73% Biochemical and Biophysical Research Communications 2 publications, 0.73%
Current Opinion in Genetics and Development	Current Opinion in Genetics and Development, 2, 0.73% Current Opinion in Genetics and Development 2 publications, 0.73%
	1 2 3 4 5 6 7 8

Citations by publishers

	5 10 15 20 25 30 35 40 45 50
Elsevier	Elsevier, 48, 17.45% Elsevier 48 publications, 17.45%
Springer Nature	Springer Nature, 43, 15.64% Springer Nature 43 publications, 15.64%
Wiley	Wiley, 35, 12.73% Wiley 35 publications, 12.73%
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Mary Ann Liebert	Mary Ann Liebert, 4, 1.45% Mary Ann Liebert 4 publications, 1.45%
SAGE	SAGE, 4, 1.45% SAGE 4 publications, 1.45%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 4, 1.45% American Society for Biochemistry and Molecular Biology 4 publications, 1.45%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 4, 1.45% American Association for Cancer Research (AACR) 4 publications, 1.45%
American Society for Clinical Investigation	American Society for Clinical Investigation, 3, 1.09% American Society for Clinical Investigation 3 publications, 1.09%
Frontiers Media S.A.	Frontiers Media S.A., 3, 1.09% Frontiers Media S.A. 3 publications, 1.09%
Canadian Science Publishing	Canadian Science Publishing, 2, 0.73% Canadian Science Publishing 2 publications, 0.73%
Portland Press	Portland Press, 2, 0.73% Portland Press 2 publications, 0.73%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 0.73% American Chemical Society (ACS) 2 publications, 0.73%
Asian Pacific Organization for Cancer Prevention	Asian Pacific Organization for Cancer Prevention, 2, 0.73% Asian Pacific Organization for Cancer Prevention 2 publications, 0.73%
Cambridge University Press	Cambridge University Press, 2, 0.73% Cambridge University Press 2 publications, 0.73%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 2, 0.73% Proceedings of the National Academy of Sciences (PNAS) 2 publications, 0.73%
American Society of Hematology	American Society of Hematology, 2, 0.73% American Society of Hematology 2 publications, 0.73%
The Company of Biologists	The Company of Biologists, 1, 0.36% The Company of Biologists 1 publication, 0.36%
S. Karger AG	S. Karger AG, 1, 0.36% S. Karger AG 1 publication, 0.36%
The Japanese Circulation Society	The Japanese Circulation Society, 1, 0.36% The Japanese Circulation Society 1 publication, 0.36%
Society of Synthetic Organic Chemistry	Society of Synthetic Organic Chemistry, 1, 0.36% Society of Synthetic Organic Chemistry 1 publication, 0.36%
V. N. Orekhovich Research Institute of Biomedical Chemistry	V. N. Orekhovich Research Institute of Biomedical Chemistry, 1, 0.36% V. N. Orekhovich Research Institute of Biomedical Chemistry 1 publication, 0.36%
	5 10 15 20 25 30 35 40 45 50

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Kyo S. et al. Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers // Cancer Science. 2008. Vol. 99. No. 8. pp. 1528-1538.

GOST all authors (up to 50) Copy

Kyo S., Takakura M., Fujiwara T., Inoue M. Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers // Cancer Science. 2008. Vol. 99. No. 8. pp. 1528-1538.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1111/j.1349-7006.2008.00878.x

UR - https://doi.org/10.1111%2Fj.1349-7006.2008.00878.x

TI - Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers

T2 - Cancer Science

AU - Kyo, Satoru

AU - Takakura, Masahiro

AU - Fujiwara, Toshiyoshi

AU - Inoue, Masaki

PY - 2008

DA - 2008/08/14 00:00:00

PB - Wiley

SP - 1528-1538

IS - 8

VL - 99

SN - 1347-9032

SN - 1349-7006

ER -

BibTex |

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BibTex Copy

@article{2008_Kyo,

author = {Satoru Kyo and Masahiro Takakura and Toshiyoshi Fujiwara and Masaki Inoue},

title = {Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers},

journal = {Cancer Science},

year = {2008},

volume = {99},

publisher = {Wiley},

month = {aug},

url = {https://doi.org/10.1111%2Fj.1349-7006.2008.00878.x},

number = {8},

pages = {1528--1538},

doi = {10.1111/j.1349-7006.2008.00878.x}

}

MLA

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MLA Copy

Kyo, Satoru, et al. “Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers.” Cancer Science, vol. 99, no. 8, Aug. 2008, pp. 1528-1538. https://doi.org/10.1111%2Fj.1349-7006.2008.00878.x.

Found error?

Publisher

Wiley

Journal

Cancer Science

Quartile SCImago

Quartile WOS

Impact factor

5.7

ISSN

13479032 (Print)
13497006 (Electronic)