Conformation of D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP-NH2), a highly selective mu-opioid antagonist peptide, by 1H and 13C n.m.r.
1
Merrell Dow Research Institute, Indianapolis, Indiana.
|
2
Merrell Dow Research Institute, Indianapolis, Indiana, USA
|
Publication type: Journal Article
Publication date: 2009-01-12
SJR: —
CiteScore: —
Impact factor: —
ISSN: 03678377
PubMed ID:
2896638
Biochemistry
Abstract
The 1H and 13C n.m.r. spectral parameters of CTP-NH2 [D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2], a potent, highly selective mu-opiate antagonist, were measured in aqueous solution and a possible conformation has been deduced from the spectral data. The data are consistent with a type II' beta-turn for the tetrapeptide sequence -Tyr3-D-Trp4-Lys5-Thr6-. Solvent shielding of the Cys2 amide proton, observed in variable temperature experiments, suggests an orientation of this amide proton toward the gem dimethyls of Pen7 with possible hydrogen bonding to the Thr6 carbonyl oxygen, and a dihedral angle of -110 degrees for the disulfide bond. Partially relaxed Fourier transform 13C relaxation studies confirm a constrained cyclic system, with the C alpha carbons in the "hinge" of the beta-turn having the shortest t1 times. Segmental motion was observed for the side chain of Lys5.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
Biopolymers
2 publications, 13.33%
|
|
|
Biochemistry
1 publication, 6.67%
|
|
|
International Journal of Peptide Research and Therapeutics
1 publication, 6.67%
|
|
|
Annals of the New York Academy of Sciences
1 publication, 6.67%
|
|
|
Journal of Peptide Research
1 publication, 6.67%
|
|
|
Magnetic Resonance in Chemistry
1 publication, 6.67%
|
|
|
Journal of Organic Chemistry
1 publication, 6.67%
|
|
|
Progress in Brain Research
1 publication, 6.67%
|
|
|
1
2
|
Publishers
|
1
2
3
4
5
6
|
|
|
Wiley
6 publications, 40%
|
|
|
American Chemical Society (ACS)
2 publications, 13.33%
|
|
|
Springer Nature
1 publication, 6.67%
|
|
|
Elsevier
1 publication, 6.67%
|
|
|
1
2
3
4
5
6
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
15
Total citations:
15
Citations from 2024:
0
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
PELTON J. T. et al. Conformation of D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP-NH2), a highly selective mu-opioid antagonist peptide, by 1H and 13C n.m.r. // International journal of peptide & protein research. 2009. Vol. 31. No. 2. pp. 109-115.
GOST all authors (up to 50)
Copy
PELTON J. T., Whalon M., Cody W. L., Hruby V. J. Conformation of D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP-NH2), a highly selective mu-opioid antagonist peptide, by 1H and 13C n.m.r. // International journal of peptide & protein research. 2009. Vol. 31. No. 2. pp. 109-115.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1111/j.1399-3011.1988.tb00012.x
UR - https://doi.org/10.1111/j.1399-3011.1988.tb00012.x
TI - Conformation of D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP-NH2), a highly selective mu-opioid antagonist peptide, by 1H and 13C n.m.r.
T2 - International journal of peptide & protein research
AU - PELTON, JOHN T.
AU - Whalon, Michael
AU - Cody, Wayne L.
AU - Hruby, Victor J.
PY - 2009
DA - 2009/01/12
PB - Wiley
SP - 109-115
IS - 2
VL - 31
PMID - 2896638
SN - 0367-8377
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2009_PELTON,
author = {JOHN T. PELTON and Michael Whalon and Wayne L. Cody and Victor J. Hruby},
title = {Conformation of D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP-NH2), a highly selective mu-opioid antagonist peptide, by 1H and 13C n.m.r.},
journal = {International journal of peptide & protein research},
year = {2009},
volume = {31},
publisher = {Wiley},
month = {jan},
url = {https://doi.org/10.1111/j.1399-3011.1988.tb00012.x},
number = {2},
pages = {109--115},
doi = {10.1111/j.1399-3011.1988.tb00012.x}
}
Cite this
MLA
Copy
PELTON, JOHN T., et al. “Conformation of D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP-NH2), a highly selective mu-opioid antagonist peptide, by 1H and 13C n.m.r..” International journal of peptide & protein research, vol. 31, no. 2, Jan. 2009, pp. 109-115. https://doi.org/10.1111/j.1399-3011.1988.tb00012.x.