Anticonvulsant Activity and Toxicity of Phensuximide, Methsuximide and Ethosuximide
1
Research Division, Parke, Davis and Company, Ann Arbor, Mich. (U.S.A.)
|
Publication type: Journal Article
Publication date: 1963-12-01
scimago Q1
wos Q1
SJR: 2.371
CiteScore: 11.4
Impact factor: 6.6
ISSN: 00139580, 15281167, 15281157
PubMed ID:
14020499
Neurology
Neurology (clinical)
Abstract
The anticonvulsant properties and toxicity of phensuximide (Milontin), methsuximide (Celontin) and ethosuximide (Zarontin) have been investigated in laboratory animals. The three compounds were very effective in suppressing the initial clonic seizures induced by Metrazol in rats and mice. Whereas methsuximide and phensuximide were capable of protecting mice from tonic extensor seizures to supramaximal electroshock at non‐neurotoxic and slightly ataxic doses respectively, ethosuximide could do so only at anesthetic dose levels. The anticonvulsant spectrum of methsuximide was shown to be similar to that of phenacemide; ethosuximide, on the other hand, resembles trimethadione very closely in anticonvulsant action. A discussion was given to correlate the anticonvulsant properties of these drugs as examined in mice and their therapeutic indications for the management of petit mal, grand mal and psychomotor epilepsy.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
7
8
|
|
|
Epilepsia
8 publications, 12.7%
|
|
|
British Journal of Pharmacology
3 publications, 4.76%
|
|
|
Journal of Applied Toxicology
3 publications, 4.76%
|
|
|
Handbook of Experimental Pharmacology
3 publications, 4.76%
|
|
|
Molecular Pharmacology
2 publications, 3.17%
|
|
|
Medicinal Chemistry
2 publications, 3.17%
|
|
|
Psychopharmacology
2 publications, 3.17%
|
|
|
Journal of Catalysis
2 publications, 3.17%
|
|
|
Neuroscience Letters
2 publications, 3.17%
|
|
|
Journal of Pharmacy and Pharmacology
2 publications, 3.17%
|
|
|
Journal of Medicinal Chemistry
1 publication, 1.59%
|
|
|
Journal of Ethnopharmacology
1 publication, 1.59%
|
|
|
Bioorganic and Medicinal Chemistry
1 publication, 1.59%
|
|
|
Epilepsy and Behavior
1 publication, 1.59%
|
|
|
Bioscience Reports
1 publication, 1.59%
|
|
|
European Archives of Psychiatry and Clinical Neuroscience
1 publication, 1.59%
|
|
|
Zeitschrift fur Epileptologie
1 publication, 1.59%
|
|
|
Biochemical Pharmacology
1 publication, 1.59%
|
|
|
Pediatric Clinics of North America
1 publication, 1.59%
|
|
|
Clinics in Laboratory Medicine
1 publication, 1.59%
|
|
|
Toxicology
1 publication, 1.59%
|
|
|
Carbohydrate Research
1 publication, 1.59%
|
|
|
European Journal of Pharmaceutical Sciences
1 publication, 1.59%
|
|
|
Journal of Pharmaceutical and Biomedical Analysis
1 publication, 1.59%
|
|
|
Neurobiology of Disease
1 publication, 1.59%
|
|
|
Journal of Neuroscience Methods
1 publication, 1.59%
|
|
|
Phytotherapy Research
1 publication, 1.59%
|
|
|
Angewandte Chemie - International Edition
1 publication, 1.59%
|
|
|
Angewandte Chemie
1 publication, 1.59%
|
|
|
1
2
3
4
5
6
7
8
|
Publishers
|
5
10
15
20
25
|
|
|
Wiley
23 publications, 36.51%
|
|
|
Elsevier
19 publications, 30.16%
|
|
|
Springer Nature
10 publications, 15.87%
|
|
|
American Chemical Society (ACS)
2 publications, 3.17%
|
|
|
Bentham Science Publishers Ltd.
2 publications, 3.17%
|
|
|
Royal Society of Chemistry (RSC)
2 publications, 3.17%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
1 publication, 1.59%
|
|
|
Taylor & Francis
1 publication, 1.59%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 1.59%
|
|
|
5
10
15
20
25
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
63
Total citations:
63
Citations from 2025:
2
(3.17%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Chen G., Weston J. K., Bratton A. Anticonvulsant Activity and Toxicity of Phensuximide, Methsuximide and Ethosuximide // Epilepsia. 1963. Vol. 4. No. 1-4. pp. 66-76.
GOST all authors (up to 50)
Copy
Chen G., Weston J. K., Bratton A. Anticonvulsant Activity and Toxicity of Phensuximide, Methsuximide and Ethosuximide // Epilepsia. 1963. Vol. 4. No. 1-4. pp. 66-76.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1111/j.1528-1157.1963.tb05209.x
UR - https://doi.org/10.1111/j.1528-1157.1963.tb05209.x
TI - Anticonvulsant Activity and Toxicity of Phensuximide, Methsuximide and Ethosuximide
T2 - Epilepsia
AU - Chen, G.
AU - Weston, J K
AU - Bratton, A.C.
PY - 1963
DA - 1963/12/01
PB - Wiley
SP - 66-76
IS - 1-4
VL - 4
PMID - 14020499
SN - 0013-9580
SN - 1528-1167
SN - 1528-1157
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1963_Chen,
author = {G. Chen and J K Weston and A.C. Bratton},
title = {Anticonvulsant Activity and Toxicity of Phensuximide, Methsuximide and Ethosuximide},
journal = {Epilepsia},
year = {1963},
volume = {4},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1111/j.1528-1157.1963.tb05209.x},
number = {1-4},
pages = {66--76},
doi = {10.1111/j.1528-1157.1963.tb05209.x}
}
Cite this
MLA
Copy
Chen, G., et al. “Anticonvulsant Activity and Toxicity of Phensuximide, Methsuximide and Ethosuximide.” Epilepsia, vol. 4, no. 1-4, Dec. 1963, pp. 66-76. https://doi.org/10.1111/j.1528-1157.1963.tb05209.x.