Plasma and Brain Levels of Δ6-THC and Seven Monooxygenated Metabolites Correlated to the Cataleptic Effect in the Mouse
1
Department of Pharmacognosy, Faculty of Pharmacy, Biomedical Center, Box 579, S‐751 23 Uppsala
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2
Astra Lakemedel AB, S-151 85 Södertälje, Sweden
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Publication type: Journal Article
Publication date: 2009-04-27
PubMed ID:
6258385
Pharmacology
Toxicology
Abstract
Abstract: The brain and plasma levels of unchanged Δ6-tetrahydrocannabinol (Δ6-THC), 7-hydroxy-Δ6-THC, the five side-chain hydroxylated Δ6-THC derivatives and 1α, 2α-epoxyhexahydrocannabinol (EHHC) were correlated to the cataleptic effect in the mouse up to 60 min. after intravenous administration of radiolabelled compounds in the range 1.3 to 12.4mg/kg. All cannabinoids except Δ6-THC and l″-hydroxy-Δ6-THC showed a very good correlation between brain/plasma concentrations and cataleptic effect. 4″-Hydroxy- and l″-hydroxy-Δ6-THC reached the highest concentration in the brain but the most potent cannabinoids were: Δ6-THC, 7-hydroxy-, 3″-hydroxy-Δ6-THC, and EHHC followed by 5″-hydroxy-, 4″-hydroxy-, 2″-hydroxy-, and 1″-hydroxy-Δ6-THC in decreasing order. It was concluded that structural rather than pharmacokinetic features are most important in determining the psychoactivity of the various cannabinoid metabolites of THC.
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GOST
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Ohlsson A. et al. Plasma and Brain Levels of Δ6-THC and Seven Monooxygenated Metabolites Correlated to the Cataleptic Effect in the Mouse // Acta Pharmacologica et Toxicologica. 2009. Vol. 47. No. 4. pp. 308-317.
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Ohlsson A., Widrnan M., CARLSSON S., Ryman T., Strid C. Plasma and Brain Levels of Δ6-THC and Seven Monooxygenated Metabolites Correlated to the Cataleptic Effect in the Mouse // Acta Pharmacologica et Toxicologica. 2009. Vol. 47. No. 4. pp. 308-317.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1111/j.1600-0773.1980.tb03660.x
UR - https://doi.org/10.1111/j.1600-0773.1980.tb03660.x
TI - Plasma and Brain Levels of Δ6-THC and Seven Monooxygenated Metabolites Correlated to the Cataleptic Effect in the Mouse
T2 - Acta Pharmacologica et Toxicologica
AU - Ohlsson, A.
AU - Widrnan, M
AU - CARLSSON, S
AU - Ryman, T
AU - Strid, C
PY - 2009
DA - 2009/04/27
PB - Wiley
SP - 308-317
IS - 4
VL - 47
PMID - 6258385
SN - 0001-6683
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2009_Ohlsson,
author = {A. Ohlsson and M Widrnan and S CARLSSON and T Ryman and C Strid},
title = {Plasma and Brain Levels of Δ6-THC and Seven Monooxygenated Metabolites Correlated to the Cataleptic Effect in the Mouse},
journal = {Acta Pharmacologica et Toxicologica},
year = {2009},
volume = {47},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1111/j.1600-0773.1980.tb03660.x},
number = {4},
pages = {308--317},
doi = {10.1111/j.1600-0773.1980.tb03660.x}
}
Cite this
MLA
Copy
Ohlsson, A., et al. “Plasma and Brain Levels of Δ6-THC and Seven Monooxygenated Metabolites Correlated to the Cataleptic Effect in the Mouse.” Acta Pharmacologica et Toxicologica, vol. 47, no. 4, Apr. 2009, pp. 308-317. https://doi.org/10.1111/j.1600-0773.1980.tb03660.x.