Journal of Applied Microbiology, volume 128, issue 3, pages 630-657
Extreme environments: microbiology leading to specialized metabolites
Sayed Ahmed M
1
,
Hassan Marwa H. A.
2
,
Alhadrami Hani A
3, 4
,
Hassan Hossam M.
1, 2
,
Goodfellow Michael
5
,
Rateb Mostafa E.
6
1
Pharmacognosy Department, Faculty of Pharmacy Nahda University Beni‐Suef Egypt
|
2
Pharmacognosy Department, Faculty of Pharmacy Beni‐Suef University Beni‐Suef Egypt
|
5
School of Natural and Environmental Sciences Newcastle University Newcastle Upon Tyne UK
|
6
School of Computing, Engineering & Physical Sciences University of the West of Scotland Paisley UK
|
Publication type: Journal Article
Publication date: 2019-08-09
Journal:
Journal of Applied Microbiology
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4
ISSN: 13645072, 13652672
General Medicine
Applied Microbiology and Biotechnology
Biotechnology
Abstract
The prevalence of multidrug-resistant microbial pathogens due to the continued misuse and overuse of antibiotics in agriculture and medicine is raising the prospect of a return to the preantibiotic days of medicine at the time of diminishing numbers of drug leads. The good news is that an increased understanding of the nature and extent of microbial diversity in natural habitats coupled with the application of new technologies in microbiology and chemistry is opening up new strategies in the search for new specialized products with therapeutic properties. This review explores the premise that harsh environmental conditions in extreme biomes, notably in deserts, permafrost soils and deep-sea sediments select for micro-organisms, especially actinobacteria, cyanobacteria and fungi, with the potential to synthesize new druggable molecules. There is evidence over the past decade that micro-organisms adapted to life in extreme habitats are a rich source of new specialized metabolites. Extreme habitats by their very nature tend to be fragile hence there is a need to conserve those known to be hot-spots of novel gifted micro-organisms needed to drive drug discovery campaigns and innovative biotechnology. This review also provides an overview of microbial-derived molecules and their biological activities focusing on the period from 2010 until 2018, over this time 186 novel structures were isolated from 129 representatives of microbial taxa recovered from extreme habitats.
Citations by journals
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12
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1 publication, 1.01%
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PeerJ
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PeerJ
1 publication, 1.01%
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Journal of Biomolecular Structure and Dynamics
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1 publication, 1.01%
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Chinese Journal of Organic Chemistry
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1 publication, 1.01%
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1 publication, 1.01%
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1 publication, 1.01%
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1 publication, 1.01%
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1 publication, 1.01%
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1 publication, 1.01%
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Extremophiles
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1 publication, 1.01%
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1 publication, 1.01%
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Pharmaceutical Research
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1 publication, 1.01%
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1 publication, 1.01%
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1 publication, 1.01%
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1 publication, 1.01%
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2
4
6
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10
12
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Citations by publishers
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5
10
15
20
25
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Multidisciplinary Digital Publishing Institute (MDPI)
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22 publications, 22.22%
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Springer Nature
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16 publications, 16.16%
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Frontiers Media S.A.
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11 publications, 11.11%
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Elsevier
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Elsevier
10 publications, 10.1%
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Taylor & Francis
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7 publications, 7.07%
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Microbiology Society
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4 publications, 4.04%
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Wiley
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Wiley
4 publications, 4.04%
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American Chemical Society (ACS)
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2 publications, 2.02%
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Pleiades Publishing
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2 publications, 2.02%
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Oxford University Press
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Oxford University Press
2 publications, 2.02%
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Xi'an Jiaotong University
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Xi'an Jiaotong University, 1, 1.01%
Xi'an Jiaotong University
1 publication, 1.01%
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American Society for Microbiology
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American Society for Microbiology
1 publication, 1.01%
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Beilstein-Institut
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Beilstein-Institut
1 publication, 1.01%
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PeerJ
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PeerJ
1 publication, 1.01%
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Shanghai Institute of Organic Chemistry
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Shanghai Institute of Organic Chemistry
1 publication, 1.01%
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5
10
15
20
25
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Sayed A. M. et al. Extreme environments: microbiology leading to specialized metabolites // Journal of Applied Microbiology. 2019. Vol. 128. No. 3. pp. 630-657.
GOST all authors (up to 50)
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Sayed A. M., Hassan M. H. A., Alhadrami H. A., Hassan H. M., Goodfellow M., Rateb M. E. Extreme environments: microbiology leading to specialized metabolites // Journal of Applied Microbiology. 2019. Vol. 128. No. 3. pp. 630-657.
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TY - JOUR
DO - 10.1111/jam.14386
UR - https://doi.org/10.1111%2Fjam.14386
TI - Extreme environments: microbiology leading to specialized metabolites
T2 - Journal of Applied Microbiology
AU - Sayed, Ahmed M
AU - Rateb, Mostafa E.
AU - Hassan, Marwa H. A.
AU - Alhadrami, Hani A
AU - Hassan, Hossam M.
AU - Goodfellow, Michael
PY - 2019
DA - 2019/08/09 00:00:00
PB - Wiley
SP - 630-657
IS - 3
VL - 128
SN - 1364-5072
SN - 1365-2672
ER -
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BibTex
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@article{2019_Sayed,
author = {Ahmed M Sayed and Mostafa E. Rateb and Marwa H. A. Hassan and Hani A Alhadrami and Hossam M. Hassan and Michael Goodfellow},
title = {Extreme environments: microbiology leading to specialized metabolites},
journal = {Journal of Applied Microbiology},
year = {2019},
volume = {128},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1111%2Fjam.14386},
number = {3},
pages = {630--657},
doi = {10.1111/jam.14386}
}
Cite this
MLA
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Sayed, Ahmed M., et al. “Extreme environments: microbiology leading to specialized metabolites.” Journal of Applied Microbiology, vol. 128, no. 3, Aug. 2019, pp. 630-657. https://doi.org/10.1111%2Fjam.14386.