A cross‐sectional epidemiological study conducted in Argentina to evaluate the impact of the exposome on skin aging

Background

Skin aging is a gradual cumulative process that may be accelerated by various exposome factors.

Aims

To investigate associations between exposome factors and facial skin aging in 11 locations in Argentina.

Patients/Methods

An observational, cross‐sectional study with assessments by exposome questionnaire, Glogau photoaging classification from I to IV, AI‐based algorithm analysis of 7 skin aging signs, and SCINEXA score.

Results

Of 1346 participants, most were women (82%), aged 31–50 years (62%), of skin phototype III (52%), and living in urban areas (94%). The Glogau skin age was higher than the chronological age for 28% of overall participants, 36% of men, and 45% of participants from Ciudad de Buenos Aires versus 12% from Jujuy (p < 0.001).

Being male (OR = 1.59; 95% CI 1.18–2.13), exposed to agrochemicals (OR = 1.59: 95% CI 1.01–2.51), of lower socioeconomic levels (OR = 2.06; 95% CI 1.32–3.21) and doing outdoor physical activity (OR = 1.33; 95% CI 1.00–1.76) increased the risk for premature aging. Odds decreased with high daily intake of water (OR = 0.76; 95% CI 0.59–0.97), daily dermocosmetic use (moisturizers [OR = 0.72; 95% CI 0.55–0.94], cleansers [OR = 0.53; CI 95% 0.42–0.67], retinoids [OR = 0.61; 95% CI 0.39–0.95]), and antiaging treatments (OR = 0.74; 95% CI 0.57–0.97).

Conclusions

Some exposome factors increased the risk for premature skin aging (physical outdoor activity, exposure to agrochemicals), while others were protective factors (high water intake, antiaging treatments, use of dermocosmetics). Locations with higher pollution levels had more premature skin aging.