Experimental Physiology, volume 99, issue 8, pages 1042-1052
AGTR2gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance
Mustafina Leysan J.
1, 2
,
Naumov Vladimir A
3
,
Cieszczyk P.
4, 5
,
Попов Д. В.
6
,
Lyubaeva Ekaterina V.
6
,
Kostryukova Elena S.
3
,
Fedotovskaya Olga N.
7
,
Druzhevskaya Anastasiya M
7
,
Astratenkova Irina V
7
,
Glotov Andrey S
8
,
Alexeev Dmitry
3
,
Mustafina Milyausha M
1
,
Egorova Emiliya S.
1
,
Maciejewska-Karłowska Agnieszka
5
,
Larin Andrey K.
3
,
Nurullin Ruslan E
2
,
Jastrzębski Zbigniew
4
,
Ospanova Elena A.
3
,
Pavlenko Alexander V.
3
,
Sawczuk Marek
5
,
Akimov Egor B
9
,
Danilushkina Anna A
1
,
Żmijewski Piotr
10
,
Виноградова О. Л.
6
,
Govorun Vadim M.
3
,
Ahmetov I. I.
1, 2, 3, 7
2
Sport Technology Research Centre; Volga Region State Academy of Physical Culture, Sport and Tourism; Kazan Russia
|
4
Department of Tourism and Recreation; Academy of Physical Education and Sport; Gdansk Poland
|
5
Department of Physical Culture and Health Promotion; University of Szczecin; Szczecin Poland
|
7
Sports Genetics Laboratory; St Petersburg Research Institute of Physical Culture; St Petersburg Russia
|
9
Centre for Sports Innovation Technologies and National Teams of the Moscow Department of Physical Culture and Sport; Moscow Russia
|
10
Department of Physiology; Institute of Sport; Warsaw Poland
|
Publication type: Journal Article
Publication date: 2014-06-30
Journal:
Experimental Physiology
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.7
ISSN: 09580670, 1469445X
Nutrition and Dietetics
Physiology
Physiology (medical)
Abstract
New Findings What is the central question of this study? Variations in genes are considered to be molecular determinants maintaining the expression of the slow or fast myosin heavy chains of adult skeletal muscle. The role of polymorphisms of candidate genes involved in skeletal muscle development, energy homeostasis and thyroid and calcium metabolism in the determination of muscle fibre type has not previously been reported. What is the main finding and its importance? We show that the AGTR2 rs11091046 C allele is associated with an increased proportion of slow-twitch muscle fibres, endurance athlete status and aerobic performance. Such findings have important implications for our understanding of muscle function in both health and disease. Muscle fibre type is a heritable trait and can partly predict athletic success. It has been proposed that polymorphisms of genes involved in the regulation of muscle fibre characteristics may predispose the muscle precursor cells of a given individual to be predominantly fast or slow. In the present study, we examined the association between 15 candidate gene polymorphisms and muscle fibre type composition of the vastus lateralis muscle in 55 physically active, healthy men. We found that rs11091046 C allele carriers of the angiotensin II type 2 receptor gene (AGTR2; involved in skeletal muscle development, metabolism and circulatory homeostasis) had a significantly higher percentage of slow-twitch fibres than A allele carriers [54.2 (11.1) versus 45.2 (10.2)%; P = 0.003]. These data indicate that 15.2% of the variation in muscle fibre composition of the vastus lateralis muscle can be explained by the AGTR2 genotype. Next, we investigated the frequencies of the AGTR2 alleles in 2178 Caucasian athletes and 1220 control subjects. The frequency of the AGTR2 C allele was significantly higher in male and female endurance athletes compared with power athletes (males, 62.7 versus 51.7%, P = 0.0038; females, 56.6 versus 48.1%, P = 0.0169) and control subjects (males, 62.7 versus 51.0%, P = 0.0006; elite female athletes, 65.1 versus 55.2%, P = 0.0488). Furthermore, the frequency of the AGTR2 A allele was significantly over-represented in female power athletes (51.9%) in comparison to control subjects (44.8%, P = 0.0069). We also found that relative maximal oxygen consumption was significantly greater in male endurance athletes with the AGTR2 C allele compared with AGTR2 A allele carriers [n = 28; 62.3 (4.4) versus 57.4 (6.0) ml min−1 kg−1; P = 0.0197]. Taken together, these results demonstrate that the AGTR2 gene C allele is associated with an increased proportion of slow-twitch muscle fibres, endurance athlete status and aerobic performance, while the A allele is associated with a higher percentage of fast-twitch fibres and power-oriented disciplines.
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1
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Mustafina L. J. et al. AGTR2gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance // Experimental Physiology. 2014. Vol. 99. No. 8. pp. 1042-1052.
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Mustafina L. J., Naumov V. A., Cieszczyk P., Попов Д. В., Lyubaeva E. V., Kostryukova E. S., Fedotovskaya O. N., Druzhevskaya A. M., Astratenkova I. V., Glotov A. S., Alexeev D., Mustafina M. M., Egorova E. S., Maciejewska-Karłowska A., Larin A. K., Generozov E. V., Nurullin R. E., Jastrzębski Z., Kulemin N. A., Ospanova E. A., Pavlenko A. V., Sawczuk M., Akimov E. B., Danilushkina A. A., Żmijewski P., Виноградова О. Л., Govorun V. M., Ahmetov I. I. AGTR2gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance // Experimental Physiology. 2014. Vol. 99. No. 8. pp. 1042-1052.
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TY - JOUR
DO - 10.1113/expphysiol.2014.079335
UR - https://doi.org/10.1113%2Fexpphysiol.2014.079335
TI - AGTR2gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance
T2 - Experimental Physiology
AU - Mustafina, Leysan J.
AU - Naumov, Vladimir A
AU - Cieszczyk, P.
AU - Попов, Д. В.
AU - Lyubaeva, Ekaterina V.
AU - Kostryukova, Elena S.
AU - Fedotovskaya, Olga N.
AU - Druzhevskaya, Anastasiya M
AU - Astratenkova, Irina V
AU - Glotov, Andrey S
AU - Alexeev, Dmitry
AU - Mustafina, Milyausha M
AU - Egorova, Emiliya S.
AU - Maciejewska-Karłowska, Agnieszka
AU - Larin, Andrey K.
AU - Generozov, Edward V.
AU - Nurullin, Ruslan E
AU - Jastrzębski, Zbigniew
AU - Kulemin, Nickolay A.
AU - Ospanova, Elena A.
AU - Pavlenko, Alexander V.
AU - Sawczuk, Marek
AU - Akimov, Egor B
AU - Danilushkina, Anna A
AU - Żmijewski, Piotr
AU - Виноградова, О. Л.
AU - Govorun, Vadim M.
AU - Ahmetov, I. I.
PY - 2014
DA - 2014/06/30 00:00:00
PB - Wiley
SP - 1042-1052
IS - 8
VL - 99
SN - 0958-0670
SN - 1469-445X
ER -
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@article{2014_Mustafina,
author = {Leysan J. Mustafina and Vladimir A Naumov and P. Cieszczyk and Д. В. Попов and Ekaterina V. Lyubaeva and Elena S. Kostryukova and Olga N. Fedotovskaya and Anastasiya M Druzhevskaya and Irina V Astratenkova and Andrey S Glotov and Dmitry Alexeev and Milyausha M Mustafina and Emiliya S. Egorova and Agnieszka Maciejewska-Karłowska and Andrey K. Larin and Edward V. Generozov and Ruslan E Nurullin and Zbigniew Jastrzębski and Nickolay A. Kulemin and Elena A. Ospanova and Alexander V. Pavlenko and Marek Sawczuk and Egor B Akimov and Anna A Danilushkina and Piotr Żmijewski and О. Л. Виноградова and Vadim M. Govorun and I. I. Ahmetov},
title = {AGTR2gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance},
journal = {Experimental Physiology},
year = {2014},
volume = {99},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1113%2Fexpphysiol.2014.079335},
number = {8},
pages = {1042--1052},
doi = {10.1113/expphysiol.2014.079335}
}
Cite this
MLA
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Mustafina, Leysan J., et al. “AGTR2gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance.” Experimental Physiology, vol. 99, no. 8, Jun. 2014, pp. 1042-1052. https://doi.org/10.1113%2Fexpphysiol.2014.079335.