Optical noninvasive diagnostics of dynamic changes in the level of blood microcirculation and oxidative metabolism using temperature tests

The problem of diabetes mellitus (DM) has attracted scientists of different specialities, as its prevalence is increasing worldwide and assumes the character of a pandemic. The use of optical non-invasive diagnostic methods is a promising direction for the early determination of the presence and severity of diabetic complications. This work is aimed at assessing changes in the uorescence intensity and the blood microcirculation level, evaluated in the skin of patients with DM with the use of local cold and heating tests. An experimental studies were carried out involving patients with type 2 DM and healthy controls. Significant differences were found in the changes in the level of microcirculation and oxidative metabolism under the in uence of local temperature effects (local heating and cooling) among patients and control group. The results can be used in further development of an optical non-invasive diagnosis of diabetes complications.