Detection of antigen-antibody interactions in microstructured optical fibers

Optical sensing is a powerful tool for recognition interactions in biosystems. Nowadays sensor systems allow to determinate the biomolecules interactions in biological fluids with high sensitivity, reproducibility and minimum standard error. Usually analyses are carried out in a heterogeneous format, which significantly complicates the procedure and increases the single analysis cost. The swap from heterogeneous to homogeneous analysis format is a promising solution. Microstructured optical fibers (MOFs) are a possible platform for creation of such sensors. Manuscript describe the possibility to detect antigen-antibody interactions in the hollow core microstructured optical fibers (HC MOFs). The determination of such interactions was carried out both in heterogeneous and homogeneous formats. Results demonstrate the prospects of HC MOF as a platform for the detection of antigen-antibody interactions.